AF1257

antibody from R&D Systems

Targeting: FCGR1A CD64, CD64A

Western blot (Data presented on provider website)

Blocking/Neutralizing (Data presented on provider website)

Antibody Data

Product number

AF1257

Provider

R&D Systems

Product name

Human Fc gamma RI/CD64 Antibody

Antibody type

Polyclonal

Description

Antigen Affinity-purified. Detects human Fc gamma RI/CD64 in direct ELISAs and Western blots. In direct ELISAs, approximately 40% cross-reactivity with recombinant mouse Fc gamma RI is observed and 10% cross-reactivity with recombinant human (rh) Fc gamma RIIA and rhFc gamma RIIIB is observed.

Reactivity

Human

Host

Goat

Conjugate

Unconjugated

Antigen sequence

P12314.2


Isotype

IgG

Vial size

100 ug

Concentration

LYOPH

Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.

References

Submitted references

Induced expression of FcγRIIIa (CD16a) on CD4+ T cells triggers generation of IFN-γhigh subset.

Chauhan AK, Chen C, Moore TL, DiPaolo RJ
The Journal of biological chemistry 2015 Feb 20;290(8):5127-5140

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Macrophage colony-stimulating factor augments Tie2-expressing monocyte differentiation, angiogenic function, and recruitment in a mouse model of breast cancer.

Forget MA, Voorhees JL, Cole SL, Dakhlallah D, Patterson IL, Gross AC, Moldovan L, Mo X, Evans R, Marsh CB, Eubank TD
PloS one 2014;9(6):e98623

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C-reactive protein induces G2/M phase cell cycle arrest and apoptosis in monocytes through the upregulation of B-cell translocation gene 2 expression.

Kim Y, Ryu J, Ryu MS, Lim S, Han KO, Lim IK, Han KH
FEBS letters 2014 Feb 14;588(4):625-31

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Immune complexes and late complement proteins trigger activation of Syk tyrosine kinase in human CD4(+) T cells.

Chauhan AK, Moore TL
Clinical and experimental immunology 2012 Feb;167(2):235-45

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C-reactive protein promotes diabetic kidney disease in a mouse model of type 1 diabetes.

Liu F, Chen HY, Huang XR, Chung AC, Zhou L, Fu P, Szalai AJ, Lan HY
Diabetologia 2011 Oct;54(10):2713-23

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C-reactive protein (CRP) induces chemokine secretion via CD11b/ICAM-1 interaction in human adherent monocytes.

Montecucco F, Steffens S, Burger F, Pelli G, Monaco C, Mach F
Journal of leukocyte biology 2008 Oct;84(4):1109-19