329943

antibody from BioLegend

Targeting: PDCD1 CD279, hSLE1, PD-1, PD1, SLEB2

Immunohistochemistry (Recommended by provider)

Flow cytometry (Data presented on provider website)

Blocking/Neutralizing (Recommended by provider)

Antibody Data

Product number

329943

Provider

BioLegend

Proper citation

BioLegend Cat#329943, RRID:AB_2565904

Product name

GoInVivo™ Purified anti-human CD279 (PD-1)

Antibody type

Monoclonal

Antigen

Other

Description

Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 (B7-H1) and PD-L2 (B7-DC) are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.

Reactivity

Human

Host

Mouse

Antibody clone number

EH12.2H7

Vial size

100 mg

Storage

2°C-8°C

Handling

Ambient RT