abx004688

antibody from Abbexa

Targeting: KCNN3 hSK3, KCa2.3, SKCA3

Western blot (Recommended by provider)

Antibody Data

Product number

abx004688

Provider

Abbexa

Product name

Potassium Intermediate/Small Conductance Calcium-Activated Channel, Subfamily N, Member 3 (KCNN3) Antibody

Antibody type

Polyclonal

Description

KCNN3 Antibody is a Rabbit Polyclonal antibody against KCNN3. Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µl

Concentration

> 1 mg/ml

Storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.