Antibody data
- Antibody Data
- Antigen structure
- References [40]
- Comments [0]
- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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Validation data
Reference
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- Product number
- 10225-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10225-1-AP, RRID:AB_2085455
- Product name
- CRABP2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CRABP2 antibody (Cat. #10225-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Disrupted protein interaction dynamics in a genetic neurodevelopmental disorder revealed by structural bioinformatics and genetic code expansion.
METTL3-mediated RanGAP1 promotes colorectal cancer progression through the MAPK pathway by recruiting YTHDF1.
CRABP2 reduces the sensitivity of Olaparib in ovarian cancer by downregulating Caspase-8 and decreasing the production of reactive oxygen species.
Depletion of LONP2 unmasks differential requirements for peroxisomal function between cell types and in cholesterol metabolism.
Structural characterization of SLYM - a 4th meningeal membrane.
The heterogeneity of tumour immune microenvironment revealing the CRABP2/CD69 signature discriminates distinct clinical outcomes in breast cancer.
The prognostic gene CRABP2 affects drug sensitivity by regulating docetaxel-induced apoptosis in breast invasive carcinoma: A pan-cancer analysis.
Molecular anatomy of adult mouse leptomeninges.
Structural characterization of SLYM-a 4th meningeal membrane.
Differential Regulation of Retinoic Acid Metabolism in Fanconi Anemia.
Effects of Fatty Acids on Proliferation of Cultured Wild-type and FABP5-KO Thymic Epithelial Cells.
Dezocine inhibits cell proliferation, migration, and invasion by targeting CRABP2 in ovarian cancer.
Upregulation of CRABP2 by TET1-mediated DNA hydroxymethylation attenuates mitochondrial apoptosis and promotes oxaliplatin resistance in gastric cancer.
Targeting CRABP-II overcomes pancreatic cancer drug resistance by reversing lipid raft cholesterol accumulation and AKT survival signaling.
All-trans retinoic acid increases the pathogenicity of the H9N2 influenza virus in mice.
The developing mouse coronal suture at single-cell resolution.
TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains.
Single-Cell Transcriptomic Analyses of the Developing Meninges Reveal Meningeal Fibroblast Diversity and Function.
Resveratrol Reverses Retinoic Acid Resistance of Anaplastic Thyroid Cancer Cells via Demethylating CRABP2 Gene.
Crabp2 Promotes Metastasis of Lung Cancer Cells via HuR and Integrin β1/FAK/ERK Signaling.
Development of Small Molecule Chimeras That Recruit AhR E3 Ligase to Target Proteins.
CRABP2 regulates invasion and metastasis of breast cancer through hippo pathway dependent on ER status.
Resveratrol Suppresses the Growth and Enhances Retinoic Acid Sensitivity of Anaplastic Thyroid Cancer Cells.
Quantitative proteomics analysis of the role of tetraspanin-8 in the drug resistance of gastric cancer.
Differential CRABP-II and FABP5 expression patterns and implications for medulloblastoma retinoic acid sensitivity.
Retinoic acid regulates cell-shape and -death of E-FABP (FABP5)-immunoreactive septoclasts in the growth plate cartilage of mice.
Divergent Hox Coding and Evasion of Retinoid Signaling Specifies Motor Neurons Innervating Digit Muscles.
Cellular Retinoic Acid Binding Protein 2 Is Strikingly Downregulated in Human Esophageal Squamous Cell Carcinoma and Functions as a Tumor Suppressor.
Association between cytoplasmic CRABP2, altered retinoic acid signaling, and poor prognosis in glioblastoma.
Col1a1+ perivascular cells in the brain are a source of retinoic acid following stroke.
Hes1 and Hes5 are required for differentiation of pituicytes and formation of the neurohypophysis in pituitary development.
CRABP-II- and FABP5-independent responsiveness of human glioblastoma cells to all-trans retinoic acid.
BLIMP1 is required for postnatal epidermal homeostasis but does not define a sebaceous gland progenitor under steady-state conditions.
Cellular retinoic acid binding protein I mediates rapid non-canonical activation of ERK1/2 by all-trans retinoic acid.
CRABP-II- and FABP5-independent all-trans retinoic acid resistance in COLO 16 human cutaneous squamous cancer cells.
CRABP-II methylation: a critical determinant of retinoic acid resistance of medulloblastoma cells.
A single progenitor population switches behavior to maintain and repair esophageal epithelium.
A role of the LIM-homeobox gene Lhx2 in the regulation of pituitary development.
Quantitative proteome analysis of HCC cell lines with different metastatic potentials by SILAC.
Dynamic regulation of retinoic acid-binding proteins in developing, adult and neoplastic skin reveals roles for beta-catenin and Notch signalling.
Marino V, Phromkrasae W, Bertacchi M, Cassini P, Chakrabandhu K, Dell'Orco D, Studer M
Protein science : a publication of the Protein Society 2024 Apr;33(4):e4953
Protein science : a publication of the Protein Society 2024 Apr;33(4):e4953
METTL3-mediated RanGAP1 promotes colorectal cancer progression through the MAPK pathway by recruiting YTHDF1.
Yang R, Yang C, Su D, Song Y, Min J, Qian Z, Shen X, Li J, Su H
Cancer gene therapy 2024 Apr;31(4):562-573
Cancer gene therapy 2024 Apr;31(4):562-573
CRABP2 reduces the sensitivity of Olaparib in ovarian cancer by downregulating Caspase-8 and decreasing the production of reactive oxygen species.
Zeng S, Xu Z, Liu Y, Zhou S, Yan Y
Chemico-biological interactions 2024 Apr 25;393:110958
Chemico-biological interactions 2024 Apr 25;393:110958
Depletion of LONP2 unmasks differential requirements for peroxisomal function between cell types and in cholesterol metabolism.
Yamashita A, Ignatenko O, Nguyen M, Lambert R, Watt K, Daneault C, Robillard-Frayne I, Topisirovic I, Rosiers CD, McBride HM
Biology direct 2023 Sep 22;18(1):60
Biology direct 2023 Sep 22;18(1):60
Structural characterization of SLYM - a 4th meningeal membrane.
Plá V, Bitsika S, Giannetto M, Ladron-de-Guevara A, Gahn-Martinez D, Mori Y, Nedergaard M, Møllgård K
Research square 2023 Oct 31;
Research square 2023 Oct 31;
The heterogeneity of tumour immune microenvironment revealing the CRABP2/CD69 signature discriminates distinct clinical outcomes in breast cancer.
Mei J, Cai Y, Chen L, Wu Y, Liu J, Qian Z, Jiang Y, Zhang P, Xia T, Pan X, Zhang Y
British journal of cancer 2023 Nov;129(10):1645-1657
British journal of cancer 2023 Nov;129(10):1645-1657
The prognostic gene CRABP2 affects drug sensitivity by regulating docetaxel-induced apoptosis in breast invasive carcinoma: A pan-cancer analysis.
Zeng S, Xu Z, Liang Q, Thakur A, Liu Y, Zhou S, Yan Y
Chemico-biological interactions 2023 Mar 1;373:110372
Chemico-biological interactions 2023 Mar 1;373:110372
Molecular anatomy of adult mouse leptomeninges.
Pietilä R, Del Gaudio F, He L, Vázquez-Liébanas E, Vanlandewijck M, Muhl L, Mocci G, Bjørnholm KD, Lindblad C, Fletcher-Sandersjöö A, Svensson M, Thelin EP, Liu J, van Voorden AJ, Torres M, Antila S, Xin L, Karlström H, Storm-Mathisen J, Bergersen LH, Moggio A, Hansson EM, Ulvmar MH, Nilsson P, Mäkinen T, Andaloussi Mäe M, Alitalo K, Proulx ST, Engelhardt B, McDonald DM, Lendahl U, Andrae J, Betsholtz C
Neuron 2023 Dec 6;111(23):3745-3764.e7
Neuron 2023 Dec 6;111(23):3745-3764.e7
Structural characterization of SLYM-a 4th meningeal membrane.
Plá V, Bitsika S, Giannetto MJ, Ladron-de-Guevara A, Gahn-Martinez D, Mori Y, Nedergaard M, Møllgård K
Fluids and barriers of the CNS 2023 Dec 14;20(1):93
Fluids and barriers of the CNS 2023 Dec 14;20(1):93
Differential Regulation of Retinoic Acid Metabolism in Fanconi Anemia.
Blaize JL, Noori BM, Hunter KP, Henrikson KA, Atoyan JA, Ardito AA, Donovan FX, Chandrasekharappa SC, Schindler D, Howlett NG
bioRxiv : the preprint server for biology 2023 Apr 27;
bioRxiv : the preprint server for biology 2023 Apr 27;
Effects of Fatty Acids on Proliferation of Cultured Wild-type and FABP5-KO Thymic Epithelial Cells.
Adachi Y
Journal of UOEH 2022;44(3):239-248
Journal of UOEH 2022;44(3):239-248
Dezocine inhibits cell proliferation, migration, and invasion by targeting CRABP2 in ovarian cancer.
Zhang C, Pan R, Ma S, Xu S, Wang B
Open medicine (Warsaw, Poland) 2022;17(1):2052-2061
Open medicine (Warsaw, Poland) 2022;17(1):2052-2061
Upregulation of CRABP2 by TET1-mediated DNA hydroxymethylation attenuates mitochondrial apoptosis and promotes oxaliplatin resistance in gastric cancer.
Tang X, Liang Y, Sun G, He Q, Hou Z, Jiang X, Gao P, Qu H
Cell death & disease 2022 Oct 4;13(10):848
Cell death & disease 2022 Oct 4;13(10):848
Targeting CRABP-II overcomes pancreatic cancer drug resistance by reversing lipid raft cholesterol accumulation and AKT survival signaling.
Yu S, Wang L, Che D, Zhang M, Li M, Naito M, Xin W, Zhou L
Journal of experimental & clinical cancer research : CR 2022 Mar 8;41(1):88
Journal of experimental & clinical cancer research : CR 2022 Mar 8;41(1):88
All-trans retinoic acid increases the pathogenicity of the H9N2 influenza virus in mice.
Niu X, Wang H, Zhao L, Lian P, Bai Y, Li J, Qiao J
Virology journal 2022 Jun 28;19(1):113
Virology journal 2022 Jun 28;19(1):113
The developing mouse coronal suture at single-cell resolution.
Farmer DT, Mlcochova H, Zhou Y, Koelling N, Wang G, Ashley N, Bugacov H, Chen HJ, Parvez R, Tseng KC, Merrill AE, Maxson RE Jr, Wilkie AOM, Crump JG, Twigg SRF
Nature communications 2021 Aug 10;12(1):4797
Nature communications 2021 Aug 10;12(1):4797
TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains.
Kaiho-Soma A, Akizuki Y, Igarashi K, Endo A, Shoda T, Kawase Y, Demizu Y, Naito M, Saeki Y, Tanaka K, Ohtake F
Molecular cell 2021 Apr 1;81(7):1411-1424.e7
Molecular cell 2021 Apr 1;81(7):1411-1424.e7
Single-Cell Transcriptomic Analyses of the Developing Meninges Reveal Meningeal Fibroblast Diversity and Function.
DeSisto J, O'Rourke R, Jones HE, Pawlikowski B, Malek AD, Bonney S, Guimiot F, Jones KL, Siegenthaler JA
Developmental cell 2020 Jul 6;54(1):43-59.e4
Developmental cell 2020 Jul 6;54(1):43-59.e4
Resveratrol Reverses Retinoic Acid Resistance of Anaplastic Thyroid Cancer Cells via Demethylating CRABP2 Gene.
Liu X, Li H, Wu ML, Wu J, Sun Y, Zhang KL, Liu J
Frontiers in endocrinology 2019;10:734
Frontiers in endocrinology 2019;10:734
Crabp2 Promotes Metastasis of Lung Cancer Cells via HuR and Integrin β1/FAK/ERK Signaling.
Wu JI, Lin YP, Tseng CW, Chen HJ, Wang LH
Scientific reports 2019 Jan 29;9(1):845
Scientific reports 2019 Jan 29;9(1):845
Development of Small Molecule Chimeras That Recruit AhR E3 Ligase to Target Proteins.
Ohoka N, Tsuji G, Shoda T, Fujisato T, Kurihara M, Demizu Y, Naito M
ACS chemical biology 2019 Dec 20;14(12):2822-2832
ACS chemical biology 2019 Dec 20;14(12):2822-2832
CRABP2 regulates invasion and metastasis of breast cancer through hippo pathway dependent on ER status.
Feng X, Zhang M, Wang B, Zhou C, Mu Y, Li J, Liu X, Wang Y, Song Z, Liu P
Journal of experimental & clinical cancer research : CR 2019 Aug 16;38(1):361
Journal of experimental & clinical cancer research : CR 2019 Aug 16;38(1):361
Resveratrol Suppresses the Growth and Enhances Retinoic Acid Sensitivity of Anaplastic Thyroid Cancer Cells.
Li YT, Tian XT, Wu ML, Zheng X, Kong QY, Cheng XX, Zhu GW, Liu J, Li H
International journal of molecular sciences 2018 Mar 29;19(4)
International journal of molecular sciences 2018 Mar 29;19(4)
Quantitative proteomics analysis of the role of tetraspanin-8 in the drug resistance of gastric cancer.
Li L, Yang D, Cui D, Li Y, Nie Z, Wang J, Liang L
International journal of oncology 2018 Feb;52(2):473-484
International journal of oncology 2018 Feb;52(2):473-484
Differential CRABP-II and FABP5 expression patterns and implications for medulloblastoma retinoic acid sensitivity.
Zhang S, Liu H, Li H, Wu M, Yu Y, Li F, Cheng X
RSC advances 2018 Apr 11;8(25):14048-14055
RSC advances 2018 Apr 11;8(25):14048-14055
Retinoic acid regulates cell-shape and -death of E-FABP (FABP5)-immunoreactive septoclasts in the growth plate cartilage of mice.
Bando Y, Yamamoto M, Sakiyama K, Sakashita H, Taira F, Miyake G, Iseki S, Owada Y, Amano O
Histochemistry and cell biology 2017 Sep;148(3):229-238
Histochemistry and cell biology 2017 Sep;148(3):229-238
Divergent Hox Coding and Evasion of Retinoid Signaling Specifies Motor Neurons Innervating Digit Muscles.
Mendelsohn AI, Dasen JS, Jessell TM
Neuron 2017 Feb 22;93(4):792-805.e4
Neuron 2017 Feb 22;93(4):792-805.e4
Cellular Retinoic Acid Binding Protein 2 Is Strikingly Downregulated in Human Esophageal Squamous Cell Carcinoma and Functions as a Tumor Suppressor.
Yang Q, Wang R, Xiao W, Sun F, Yuan H, Pan Q
PloS one 2016;11(2):e0148381
PloS one 2016;11(2):e0148381
Association between cytoplasmic CRABP2, altered retinoic acid signaling, and poor prognosis in glioblastoma.
Liu RZ, Li S, Garcia E, Glubrecht DD, Poon HY, Easaw JC, Godbout R
Glia 2016 Jun;64(6):963-76
Glia 2016 Jun;64(6):963-76
Col1a1+ perivascular cells in the brain are a source of retinoic acid following stroke.
Kelly KK, MacPherson AM, Grewal H, Strnad F, Jones JW, Yu J, Pierzchalski K, Kane MA, Herson PS, Siegenthaler JA
BMC neuroscience 2016 Jul 15;17(1):49
BMC neuroscience 2016 Jul 15;17(1):49
Hes1 and Hes5 are required for differentiation of pituicytes and formation of the neurohypophysis in pituitary development.
Goto M, Hojo M, Ando M, Kita A, Kitagawa M, Ohtsuka T, Kageyama R, Miyamoto S
Brain research 2015 Nov 2;1625:206-17
Brain research 2015 Nov 2;1625:206-17
CRABP-II- and FABP5-independent responsiveness of human glioblastoma cells to all-trans retinoic acid.
Xia SL, Wu ML, Li H, Wang JH, Chen NN, Chen XY, Kong QY, Sun Z, Liu J
Oncotarget 2015 Mar 20;6(8):5889-902
Oncotarget 2015 Mar 20;6(8):5889-902
BLIMP1 is required for postnatal epidermal homeostasis but does not define a sebaceous gland progenitor under steady-state conditions.
Kretzschmar K, Cottle DL, Donati G, Chiang MF, Quist SR, Gollnick HP, Natsuga K, Lin KI, Watt FM
Stem cell reports 2014 Oct 14;3(4):620-33
Stem cell reports 2014 Oct 14;3(4):620-33
Cellular retinoic acid binding protein I mediates rapid non-canonical activation of ERK1/2 by all-trans retinoic acid.
Persaud SD, Lin YW, Wu CY, Kagechika H, Wei LN
Cellular signalling 2013 Jan;25(1):19-25
Cellular signalling 2013 Jan;25(1):19-25
CRABP-II- and FABP5-independent all-trans retinoic acid resistance in COLO 16 human cutaneous squamous cancer cells.
Chen NN, Li Y, Wu ML, Liu ZL, Fu YS, Kong QY, Chen XY, Li H, Liu J
Experimental dermatology 2012 Jan;21(1):13-8
Experimental dermatology 2012 Jan;21(1):13-8
CRABP-II methylation: a critical determinant of retinoic acid resistance of medulloblastoma cells.
Fu YS, Wang Q, Ma JX, Yang XH, Wu ML, Zhang KL, Kong QY, Chen XY, Sun Y, Chen NN, Shu XH, Li H, Liu J
Molecular oncology 2012 Feb;6(1):48-61
Molecular oncology 2012 Feb;6(1):48-61
A single progenitor population switches behavior to maintain and repair esophageal epithelium.
Doupé DP, Alcolea MP, Roshan A, Zhang G, Klein AM, Simons BD, Jones PH
Science (New York, N.Y.) 2012 Aug 31;337(6098):1091-3
Science (New York, N.Y.) 2012 Aug 31;337(6098):1091-3
A role of the LIM-homeobox gene Lhx2 in the regulation of pituitary development.
Zhao Y, Mailloux CM, Hermesz E, Palkóvits M, Westphal H
Developmental biology 2010 Jan 15;337(2):313-23
Developmental biology 2010 Jan 15;337(2):313-23
Quantitative proteome analysis of HCC cell lines with different metastatic potentials by SILAC.
Chen N, Sun W, Deng X, Hao Y, Chen X, Xing B, Jia W, Ma J, Wei H, Zhu Y, Qian X, Jiang Y, He F
Proteomics 2008 Dec;8(23-24):5108-18
Proteomics 2008 Dec;8(23-24):5108-18
Dynamic regulation of retinoic acid-binding proteins in developing, adult and neoplastic skin reveals roles for beta-catenin and Notch signalling.
Collins CA, Watt FM
Developmental biology 2008 Dec 1;324(1):55-67
Developmental biology 2008 Dec 1;324(1):55-67
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 10225-1-AP(CRABP2 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-CRABP2 (IP:10225-1-AP, 3ug; Detection:10225-1-AP 1:300) with HeLa cells lysate 4650ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The CRABP2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CRABP2. This antibody recognizes human,mouse,rat antigen. The CRABP2 antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.