BS8508

antibody from Bioworld Technology, Inc
Targeting: CRABP2 CRABP-II
Provider product page for BS8508
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS8508 - Provider product page
Provider
Bioworld Technology, Inc
Product name
CRABP2 polyclonal antibody
Antibody type
Polyclonal
Antigen
Cellular retinoic acid-binding protein 2; Cellular retinoic acid-binding protein II; CRABPII; CRABP II; CRABP2; CRABP 2
Description
The cellular retinoic acid-binding protein (CRABP)-I and a related isoform CRABP-II are nuclear receptors for retinoic acid (RA), an important regulator of cell growth and differentiation in fetal and adult tissues. These CRABP proteins mediate the downstream effects of RA in distinct ways. CRABP-I negatively regulates the activity of RA by enhancing the production of RAmetabolizing enzymes and increasing the rate at which RA is degraded. CRABP-II enhances the effects of RA by directly interacting with RA receptors (RAR) and, in turn, promoting the formation of RAR-RA complexes and stimulating RA-mediated gene transcription. Both CRABP-I and CRABP-II are expressed in the embryo, and CRABP-I is ubiquitously expressed in various adult tissues. The expression of CRABP-II is elevated in cells that synthesize relatively large amounts of RA, and it is also predominantly expressed in skin, uterus, ovary, and in the choroid plexus.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
CRABP2 protein structure - BS8508 shown in red.