BS8515

antibody from Bioworld Technology, Inc
Targeting: GCK HK4, MODY2
Provider product page for BS8515
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS8515 - Provider product page
Provider
Bioworld Technology, Inc
Product name
GCK polyclonal antibody
Antibody type
Polyclonal
Antigen
Glucokinase; Hexokinase type IV; HK IV; Hexokinase-4; HK4; Hexokinase-D; GCK
Description
Glucokinase (also designated hexokinase IV, HXKIV or GCK) plays a key role in the regulation of glucose-induced insulin secretion. GCK is expressed in pancreatic beta cells where it functions as the major glucose sensor of the body, determining the ¡ùset point¡ì for insulin secretion. GCK is also expressed in the liver, where it catalyzes the first committed step in the disposal of glucose. Phosphorylation of glucose by glucokinase appears to be the ratelimiting step for glucose catabolism. A lack of glucokinase activity leads to reduced insulin secretion and hyperglycemia, and has been implicated as a cause for maturity onset diabetes of the youth (MODY). In fact, heterozygous point mutations in the gene encoding GCK have been detected in individuals suffering from MODY.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
GCK protein structure - BS8515 shown in red.