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Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [2]
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- Validations
- Flow cytometry [1]
- Other assay [1]
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- Product number
- 14-0018-82 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- CD1b Monoclonal Antibody (eBioSN13 (SN13 K5-1B8)), eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: The eBioSN13 monoclonal antibody reacts with human CD1b. The CD1 molecules are similar to MHC class I, but rather than presenting peptide antigens to T-cell receptors (TCR), they present a diversity of lipid and glycolipid antigens which are derived from self as well as from mycobacteria which include sphingolipids, mycolic acid derivatives and phosphatidylinositols such as liparabinomannan (LAM) and glucose monomycolate (GMM). CD1b is 45 kDa, and like the other CD1 antigens, is expressed as a heterodimer composed of the CD1b noncovalently paired with beta2-microglobulin.
- Antibody clone number
- eBioSN13 (SN13 K5-1B8)
- Concentration
- 0.5 mg/mL
Submitted references Influence of Mycobacterium bovis bacillus Calmette Guérin on in vitro induction of CD1 molecules in human adherent mononuclear cells.
Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c.
Giuliani A, Prete SP, Graziani G, Aquino A, Balduzzi A, Sugita M, Brenner MB, Iona E, Fattorini L, Orefici G, Porcelli SA, Bonmassar E
Infection and immunity 2001 Dec;69(12):7461-70
Infection and immunity 2001 Dec;69(12):7461-70
Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c.
Martin LH, Calabi F, Lefebvre FA, Bilsland CA, Milstein C
Proceedings of the National Academy of Sciences of the United States of America 1987 Dec;84(24):9189-93
Proceedings of the National Academy of Sciences of the United States of America 1987 Dec;84(24):9189-93
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Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Staining of Molt-4 cell line with 0.5 µg of Mouse IgG1 kappa Isotype Control Purified (Product # 14-4714-82) (open histogram) or 0.5 µg of Anti-Human CD1b Purified (filled histogram) followed by Anti-Mouse IgG Biotin (Product # 13-4013-85) and Streptavidin PE (Product # 12-4317-87). Total viable cells were used for analysis.
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
