Antibody data
- Antibody Data
- Antigen structure
- References [17]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 10746-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10746-1-AP, RRID:AB_2271311
- Product name
- STK11/ LKB1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated STK11/ LKB1 antibody (Cat. #10746-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Free fatty acid impairs myogenic differentiation through AMPKα-miR-206 pathway.
CARS senses cysteine deprivation to activate AMPK for cell survival.
Role of Epigallocatechin Gallate in Glucose, Lipid, and Protein Metabolism and L-Theanine in the Metabolism-Regulatory Effects of Epigallocatechin Gallate.
LKB1/AMPKα signaling pathway and mitochondrial fission/fusion dynamics regulate apoptosis induced by 3-chlorpropane-1,2-diol in HEK293 cells.
Liver kinase B1 attenuates liver ischemia/reperfusion injury via inhibiting the NLRP3 inflammasome.
Puerarin Attenuates Diabetic Nephropathy by Promoting Autophagy in Podocytes.
Human papillomavirus 16 (HPV 16) E6 but not E7 inhibits the antitumor activity of LKB1 in lung cancer cells by downregulating the expression of KIF7.
Sirt3 modulates fatty acid oxidation and attenuates cisplatin-induced AKI in mice.
Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents.
CircACC1 Regulates Assembly and Activation of AMPK Complex under Metabolic Stress.
Tim-4 Inhibits NLRP3 Inflammasome via the LKB1/AMPKα Pathway in Macrophages.
Aldolase promotes the development of cardiac hypertrophy by targeting AMPK signaling.
Antagonizing peroxisome proliferator-activated receptor γ facilitates M1-to-M2 shift of microglia by enhancing autophagy via the LKB1-AMPK signaling pathway.
Rosiglitazone Exerts an Anti-depressive Effect in Unpredictable Chronic Mild-Stress-Induced Depressive Mice by Maintaining Essential Neuron Autophagy and Inhibiting Excessive Astrocytic Apoptosis.
Triptolide induces protective autophagy through activation of the CaMKKβ-AMPK signaling pathway in prostate cancer cells.
Decreased LKB1 predicts poor prognosis in Pancreatic Ductal Adenocarcinoma.
The LKB1 tumor suppressor as a biomarker in mouse and human tissues.
Jiang A, Guo H, Zhang L, Jiang X, Zhang X, Wu W, Liu H
Molecular and cellular biology 2021 Oct 25;:MCB0032721
Molecular and cellular biology 2021 Oct 25;:MCB0032721
CARS senses cysteine deprivation to activate AMPK for cell survival.
Yuan M, Yan R, Zhang Y, Qiu Y, Jiang Z, Liu H, Wang Y, Sun L, Zhang H, Gao P
The EMBO journal 2021 Nov 2;40(21):e108028
The EMBO journal 2021 Nov 2;40(21):e108028
Role of Epigallocatechin Gallate in Glucose, Lipid, and Protein Metabolism and L-Theanine in the Metabolism-Regulatory Effects of Epigallocatechin Gallate.
Lin L, Zeng L, Liu A, Yuan D, Peng Y, Zhang S, Li Y, Chen J, Xiao W, Gong Z
Nutrients 2021 Nov 17;13(11)
Nutrients 2021 Nov 17;13(11)
LKB1/AMPKα signaling pathway and mitochondrial fission/fusion dynamics regulate apoptosis induced by 3-chlorpropane-1,2-diol in HEK293 cells.
Jin C, Xue W, Liu Q, Han J, Luo R, Feng J, Liu J, Guo T, Peng X, Hu T
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Aug;154:112350
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Aug;154:112350
Liver kinase B1 attenuates liver ischemia/reperfusion injury via inhibiting the NLRP3 inflammasome.
Dai J, Chen Q, Huang W, Shi K, Zhang Y, Li T, Mou T, Huang Z, Wu Z
Acta biochimica et biophysica Sinica 2021 Apr 15;53(5):601-611
Acta biochimica et biophysica Sinica 2021 Apr 15;53(5):601-611
Puerarin Attenuates Diabetic Nephropathy by Promoting Autophagy in Podocytes.
Li X, Zhu Q, Zheng R, Yan J, Wei M, Fan Y, Deng Y, Zhong Y
Frontiers in physiology 2020;11:73
Frontiers in physiology 2020;11:73
Human papillomavirus 16 (HPV 16) E6 but not E7 inhibits the antitumor activity of LKB1 in lung cancer cells by downregulating the expression of KIF7.
Hu Y, Wu MZ, Gu NJ, Xu HT, Li QC, Wu GP
Thoracic cancer 2020 Nov;11(11):3175-3180
Thoracic cancer 2020 Nov;11(11):3175-3180
Sirt3 modulates fatty acid oxidation and attenuates cisplatin-induced AKI in mice.
Li M, Li CM, Ye ZC, Huang J, Li Y, Lai W, Peng H, Lou TQ
Journal of cellular and molecular medicine 2020 May;24(9):5109-5121
Journal of cellular and molecular medicine 2020 May;24(9):5109-5121
Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents.
Wang Z, Chen Z, Jiang Z, Luo P, Liu L, Huang Y, Wang H, Wang Y, Long L, Tan X, Liu D, Jin T, Wang Y, Wang Y, Liao F, Zhang C, Chen L, Gan Y, Liu Y, Yang F, Huang C, Miao H, Chen J, Cheng T, Fu X, Shi C
Nature communications 2019 Jun 10;10(1):2538
Nature communications 2019 Jun 10;10(1):2538
CircACC1 Regulates Assembly and Activation of AMPK Complex under Metabolic Stress.
Li Q, Wang Y, Wu S, Zhou Z, Ding X, Shi R, Thorne RF, Zhang XD, Hu W, Wu M
Cell metabolism 2019 Jul 2;30(1):157-173.e7
Cell metabolism 2019 Jul 2;30(1):157-173.e7
Tim-4 Inhibits NLRP3 Inflammasome via the LKB1/AMPKα Pathway in Macrophages.
Liu W, Bai F, Wang H, Liang Y, Du X, Liu C, Cai D, Peng J, Zhong G, Liang X, Ma C, Gao L
Journal of immunology (Baltimore, Md. : 1950) 2019 Aug 15;203(4):990-1000
Journal of immunology (Baltimore, Md. : 1950) 2019 Aug 15;203(4):990-1000
Aldolase promotes the development of cardiac hypertrophy by targeting AMPK signaling.
Li Y, Zhang D, Kong L, Shi H, Tian X, Gao L, Liu Y, Wu L, Du B, Huang Z, Liang C, Wang Z, Yao R, Zhang Y
Experimental cell research 2018 Sep 1;370(1):78-86
Experimental cell research 2018 Sep 1;370(1):78-86
Antagonizing peroxisome proliferator-activated receptor γ facilitates M1-to-M2 shift of microglia by enhancing autophagy via the LKB1-AMPK signaling pathway.
Ji J, Xue TF, Guo XD, Yang J, Guo RB, Wang J, Huang JY, Zhao XJ, Sun XL
Aging cell 2018 Aug;17(4):e12774
Aging cell 2018 Aug;17(4):e12774
Rosiglitazone Exerts an Anti-depressive Effect in Unpredictable Chronic Mild-Stress-Induced Depressive Mice by Maintaining Essential Neuron Autophagy and Inhibiting Excessive Astrocytic Apoptosis.
Zhao Z, Zhang L, Guo XD, Cao LL, Xue TF, Zhao XJ, Yang DD, Yang J, Ji J, Huang JY, Sun XL
Frontiers in molecular neuroscience 2017;10:293
Frontiers in molecular neuroscience 2017;10:293
Triptolide induces protective autophagy through activation of the CaMKKβ-AMPK signaling pathway in prostate cancer cells.
Zhao F, Huang W, Zhang Z, Mao L, Han Y, Yan J, Lei M
Oncotarget 2016 Feb 2;7(5):5366-82
Oncotarget 2016 Feb 2;7(5):5366-82
Decreased LKB1 predicts poor prognosis in Pancreatic Ductal Adenocarcinoma.
Yang JY, Jiang SH, Liu DJ, Yang XM, Huo YM, Li J, Hua R, Zhang ZG, Sun YW
Scientific reports 2015 May 27;5:10575
Scientific reports 2015 May 27;5:10575
The LKB1 tumor suppressor as a biomarker in mouse and human tissues.
Nakada Y, Stewart TG, Peña CG, Zhang S, Zhao N, Bardeesy N, Sharpless NE, Wong KK, Hayes DN, Castrillon DH
PloS one 2013;8(9):e73449
PloS one 2013;8(9):e73449
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 10746-1-AP(STK11 antibody) at dilution of 1:600
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The LKB1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human LKB1. This antibody recognizes human,mouse,rat antigen. The LKB1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.