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Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [4]
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- Validations
- Flow cytometry [1]
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- Product number
- 13-0849-82 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- CD84 Monoclonal Antibody (2G7), Biotin, eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: The monoclonal antibody 2G7 reacts to CD84, a transmembrane protein of the Ig SLAM superfamily. Expression of CD84 is found on mature B cells, a subset of T cells (mainly CD4+CD45RA+), monocytes and platelets. CD84 is found on a percentage of human hematopoietic progenitor (CD34+) cells. Signaling through CD84 via homotypic interactions involves phosphorylation and recruitment of SAP and EAT-2 leading to production of IFNgamma and T cell activation.
- Conjugate
- Biotin
- Antibody clone number
- 2G7
- Concentration
- 0.5 mg/mL
Submitted references Atypical and classical memory B cells produce Plasmodium falciparum neutralizing antibodies.
The SLAM family member CD84 is regulated by ADAM10 and calpain in platelets.
The transmembrane form of the CX3CL1 chemokine fractalkine is expressed predominantly by epithelial cells in vivo.
CD84 leukocyte antigen is a new member of the Ig superfamily.
Muellenbeck MF, Ueberheide B, Amulic B, Epp A, Fenyo D, Busse CE, Esen M, Theisen M, Mordmüller B, Wardemann H
The Journal of experimental medicine 2013 Feb 11;210(2):389-99
The Journal of experimental medicine 2013 Feb 11;210(2):389-99
The SLAM family member CD84 is regulated by ADAM10 and calpain in platelets.
Hofmann S, Vögtle T, Bender M, Rose-John S, Nieswandt B
Journal of thrombosis and haemostasis : JTH 2012 Dec;10(12):2581-92
Journal of thrombosis and haemostasis : JTH 2012 Dec;10(12):2581-92
The transmembrane form of the CX3CL1 chemokine fractalkine is expressed predominantly by epithelial cells in vivo.
Lucas AD, Chadwick N, Warren BF, Jewell DP, Gordon S, Powrie F, Greaves DR
The American journal of pathology 2001 Mar;158(3):855-66
The American journal of pathology 2001 Mar;158(3):855-66
CD84 leukocyte antigen is a new member of the Ig superfamily.
de la Fuente MA, Pizcueta P, Nadal M, Bosch J, Engel P
Blood 1997 Sep 15;90(6):2398-405
Blood 1997 Sep 15;90(6):2398-405
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Supportive validation
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- Invitrogen Antibodies (provider)
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- Experimental details
- Staining of normal human peripheral blood cells with Mouse IgG1 K Isotype Control Biotin (Product # 13-4714-85) (blue histogram) or Anti-Human CD84 Biotin (purple histogram) followed by Streptavidin PE (Product # 12-4317-87). Cells in the lymphocyte gate were used for analysis.
- Conjugate
- Biotin
