Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- BS60231 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- RGS4 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- A synthetic peptide corresponding to residues in Human RGS4.
- Description
- Heterotrimeric G proteins function to relay information from cell surface receptors to intracellular effectors. In mammals, G protein Ï«, ÉÇ and ÎÛ polypeptides are encoded by at least 16, 4 and 7 genes, respectively. Most interest in G proteins has been focused on their Ï« subunits, since these proteins bind and hydrolyze GTP and most obviously regulate the activity of the best studied effectors. Four GÏ« GTPase-activating proteins (GAPs) have been identified and are designated RGS1 (regulator of G protein signaling), RGS4, RGS10 and GAIP (GÏ«-interacting protein). Each of these proteins has been shown to deactivate specific GÏ« isoforms by increasing the rate at which they convert GTP to GDP. RGS1, RGS4 and GAIP bind tightly to and exhibit GAP activity towards GÏ« i, GÏ« o and GÏ« t, but not GÏ« s. RGS10 increases the GTP hydrolytic activity of several members of the GÏ« i subfamily including GÏ« i-3, GÏ« z, and GÏ« o.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- Western blot (WB) analysis of RGS4 pAb at 1:500 dilutionLane1:HepG2 whole cell lysateLane2:sp2/0 whole cell lysateLane3:PC12 whole cell lysate