BS2555

antibody from Bioworld Technology, Inc

Targeting: ACVRL1 ACVRLK1, ALK1, HHT, HHT2, ORW2

Immunocytochemistry

Immunohistochemistry

Antibody data

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Validation data

Product number: BS2555 - Provider product page
Provider: Bioworld Technology, Inc
Proper citation: Bioworld Technology Cat#BS2555, RRID:AB_1663497
Product name: ACVRL1 (F231) polyclonal antibody
Antibody type: Polyclonal
Antigen: Synthetic peptide, corresponding to amino acids 200-250 of Human ACVRL1.
Description: Mutations in two genes, Endoglin (also designated CD105) and ACVRL1 (activin receptorlike kinase 1, also designated TGFÉÇ superfamily RI), are responsible for HHT. Endoglin is mutated in HHT1, and ALK-1 is mutated in HHT2, both of which are thought to be caused by haploinsufficiency. Endoglin and ALK-1 are type III and type I members of the TGFÉÇ receptor superfamily, respectively, that are expressed on vascular endothelial cells. Endoglin can only bind ligands of the TGFÉÇ superfamily via association with the respective ligand binding receptors for TGFÉÇ1, TGFÉÇ3, Activin-A, BMP-2 and BMP-7. ALK-1 preferentially binds TGFÉÇ1 and is expressed in bone marrow stromal cells, lung, brain, kidney and spleen.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Vial size: 100ul
Concentration: 1 mg/ml
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

ACVRL1 protein structure - BS2555 shown in red.