AF770

antibody from R&D Systems

Targeting: ACVRL1 ACVRLK1, ALK1, HHT, HHT2, ORW2

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Antibody Data

Product number

AF770

Provider

R&D Systems

Product name

Mouse ALK-1 Antibody

Antibody type

Polyclonal

Description

Immunogen affinity purified. Detects mouse ALK-1 in ELISAs and Western blots. In sandwich immunoassays, less than 5% cross-reactivity with recombinant human ALK-1 is observed.

Reactivity

Mouse

Host

Goat

Conjugate

Unconjugated

Antigen sequence

Q61288


Isotype

IgG

Vial size

100 ug

Concentration

LYOPH

Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.

References

Submitted references

PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia.

Ola R, Dubrac A, Han J, Zhang F, Fang JS, Larrivée B, Lee M, Urarte AA, Kraehling JR, Genet G, Hirschi KK, Sessa WC, Canals FV, Graupera M, Yan M, Young LH, Oh PS, Eichmann A
Nature communications 2016 Nov 29;7:13650

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BMP9/ALK1 inhibits neovascularization in mouse models of age-related macular degeneration.

Ntumba K, Akla N, Oh SP, Eichmann A, Larrivée B
Oncotarget 2016 Aug 30;7(35):55957-55969

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Endothelial β4 integrin is predominantly expressed in arterioles, where it promotes vascular remodeling in the hypoxic brain.

Welser-Alves JV, Boroujerdi A, Tigges U, Wrabetz L, Feltri ML, Milner R
Arteriosclerosis, thrombosis, and vascular biology 2013 May;33(5):943-53

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ALK1-Fc inhibits multiple mediators of angiogenesis and suppresses tumor growth.

Mitchell D, Pobre EG, Mulivor AW, Grinberg AV, Castonguay R, Monnell TE, Solban N, Ucran JA, Pearsall RS, Underwood KW, Seehra J, Kumar R
Molecular cancer therapeutics 2010 Feb;9(2):379-88