10-7542

antibody from ABEOMICS Inc.
Targeting: ACVRL1 ACVRLK1, ALK1, HHT, HHT2, ORW2
Provider product page for 10-7542

Antibody data

Product number
10-7542 - Provider product page
Provider
ABEOMICS Inc.
Product name
Anti-ALK-1 Antibody
Antibody type
Monoclonal
Description
ALK-1 or Activin receptor-like kinase-1 is a type I cell surface receptor for the TGF-beta (transforming growth factor-beta) super family of proteins. It is expressed predominantly in endothelial cells with moderate expression in smooth muscle cells, myofibroblast, hepatic stellate cells, chondrocytes, monocytes, myoblasts, macrophages and fibroblasts. ALK-1 plays a pivotal role in vascular remodelling and angiogenesis. More specifically its key function is in arterial/venous differentiation during embryonic vascular development. Mutations in ALK-1 gene (12q11-14) causes HHT2 (Hereditary Haemorrhagic Telangiectasia type 2), an autosomal dominant multisystem vascular dysplasia caused by a haploinsufficiency mechanism.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antigen sequence
A partial length recombinant ALK-1
protein (amino acids 310-503) was u
sed as the immunogen for this antib
ody
Isotype
IgG
Antibody clone number
ABM43C4
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing
ACVRL1 protein structure - 10-7542 shown in red.