Antibody data
- Antibody Data
- Antigen structure
- References [17]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
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- Product number
- 19662-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#19662-1-AP, RRID:AB_10859778
- Product name
- Hexokinase 1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Hexokinase 1 antibody (Cat. #19662-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Targeting HLA-F suppresses the proliferation of glioma cells via a reduction in hexokinase 2-dependent glycolysis.
Long non-coding RNA CTSLP8 mediates ovarian cancer progression and chemotherapy resistance by modulating cellular glycolysis and regulating c-Myc expression through PKM2.
HIF-1 regulates energy metabolism of the Tibetan chicken brain during embryo development under hypoxia.
Androgen Receptor Stimulates Hexokinase 2 and Induces Glycolysis by PKA/CREB Signaling in Hepatocellular Carcinoma.
SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis.
Downregulation of GLUT3 impairs STYK1/NOK-mediated metabolic reprogramming and proliferation in NIH-3T3 cells.
NF-κB-inducing kinase maintains T cell metabolic fitness in antitumor immunity.
JAK2V617F Mutation Promoted IL-6 Production and Glycolysis via Mediating PKM1 Stabilization in Macrophages.
Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer's disease.
Loss of hepatic aldolase B activates Akt and promotes hepatocellular carcinogenesis by destabilizing the Aldob/Akt/PP2A protein complex.
Localisation and function of glucose transporter GLUT1 in chicken (Gallus gallus domesticus) spermatozoa: relationship between ATP production pathways and flagellar motility.
Deoxyelephantopin suppresses hepatic stellate cells activation associated with inhibition of aerobic glycolysis via hedgehog pathway.
Accelerated Metabolite Levels of Aerobic Glycolysis and the Pentose Phosphate Pathway Are Required for Efficient Replication of Infectious Spleen and Kidney Necrosis Virus in Chinese Perch Brain Cells.
The combination of metformin and 2-deoxyglucose significantly inhibits cyst formation in miniature pigs with polycystic kidney disease.
Inhibition of hexokinases holds potential as treatment strategy for rheumatoid arthritis.
The changes in glucose metabolism and cell proliferation in the kidneys of polycystic kidney disease mini-pig models.
Poly(ADP-ribose) polymerase regulates glycolytic activity in kidney proximal tubule epithelial cells.
Chen X, Sun N, Li R, Sang X, Li X, Zhao J, Han J, Yang J, Ikezoe T
International journal of biological sciences 2021;17(5):1263-1276
International journal of biological sciences 2021;17(5):1263-1276
Long non-coding RNA CTSLP8 mediates ovarian cancer progression and chemotherapy resistance by modulating cellular glycolysis and regulating c-Myc expression through PKM2.
Li X, Zhang Y, Wang X, Lin F, Cheng X, Wang Z, Wang X
Cell biology and toxicology 2021 Sep 12;
Cell biology and toxicology 2021 Sep 12;
HIF-1 regulates energy metabolism of the Tibetan chicken brain during embryo development under hypoxia.
Tang Q, Xu Q, Ding C, Zhang H, Ling Y, Wu C, Fang M
American journal of physiology. Regulatory, integrative and comparative physiology 2021 May 1;320(5):R704-R713
American journal of physiology. Regulatory, integrative and comparative physiology 2021 May 1;320(5):R704-R713
Androgen Receptor Stimulates Hexokinase 2 and Induces Glycolysis by PKA/CREB Signaling in Hepatocellular Carcinoma.
Sun RF, Zhao CY, Chen S, Yu W, Zhou MM, Gao CR
Digestive diseases and sciences 2021 Mar;66(3):802-813
Digestive diseases and sciences 2021 Mar;66(3):802-813
SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis.
Shangguan X, He J, Ma Z, Zhang W, Ji Y, Shen K, Yue Z, Li W, Xin Z, Zheng Q, Cao Y, Pan J, Dong B, Cheng J, Wang Q, Xue W
Nature communications 2021 Mar 22;12(1):1812
Nature communications 2021 Mar 22;12(1):1812
Downregulation of GLUT3 impairs STYK1/NOK-mediated metabolic reprogramming and proliferation in NIH-3T3 cells.
Shi W, Fu Y, Wang Y
Oncology letters 2021 Jul;22(1):527
Oncology letters 2021 Jul;22(1):527
NF-κB-inducing kinase maintains T cell metabolic fitness in antitumor immunity.
Gu M, Zhou X, Sohn JH, Zhu L, Jie Z, Yang JY, Zheng X, Xie X, Yang J, Shi Y, Brightbill HD, Kim JB, Wang J, Cheng X, Sun SC
Nature immunology 2021 Feb;22(2):193-204
Nature immunology 2021 Feb;22(2):193-204
JAK2V617F Mutation Promoted IL-6 Production and Glycolysis via Mediating PKM1 Stabilization in Macrophages.
Li R, Sun N, Chen X, Li X, Zhao J, Cheng W, Hua H, Fukatsu M, Mori H, Takahashi H, Ohkawara H, Fukami M, Okamoto M, Hamazaki Y, Zheng K, Yang J, Ikezoe T
Frontiers in immunology 2020;11:589048
Frontiers in immunology 2020;11:589048
Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer's disease.
Zhang X, Wang R, Hu D, Sun X, Fujioka H, Lundberg K, Chan ER, Wang Q, Xu R, Flanagan ME, Pieper AA, Qi X
Science advances 2020 Dec;6(49)
Science advances 2020 Dec;6(49)
Loss of hepatic aldolase B activates Akt and promotes hepatocellular carcinogenesis by destabilizing the Aldob/Akt/PP2A protein complex.
He X, Li M, Yu H, Liu G, Wang N, Yin C, Tu Q, Narla G, Tao Y, Cheng S, Yin H
PLoS biology 2020 Dec;18(12):e3000803
PLoS biology 2020 Dec;18(12):e3000803
Localisation and function of glucose transporter GLUT1 in chicken (Gallus gallus domesticus) spermatozoa: relationship between ATP production pathways and flagellar motility.
Setiawan R, Priyadarshana C, Tajima A, Travis AJ, Asano A
Reproduction, fertility, and development 2020 Apr;32(7):697-705
Reproduction, fertility, and development 2020 Apr;32(7):697-705
Deoxyelephantopin suppresses hepatic stellate cells activation associated with inhibition of aerobic glycolysis via hedgehog pathway.
Gao W, Sun J, Wang F, Lu Y, Wen C, Bian Q, Wu H
Biochemical and biophysical research communications 2019 Sep 3;516(4):1222-1228
Biochemical and biophysical research communications 2019 Sep 3;516(4):1222-1228
Accelerated Metabolite Levels of Aerobic Glycolysis and the Pentose Phosphate Pathway Are Required for Efficient Replication of Infectious Spleen and Kidney Necrosis Virus in Chinese Perch Brain Cells.
Guo X, Wu S, Li N, Lin Q, Liu L, Liang H, Niu Y, Huang Z, Fu X
Biomolecules 2019 Sep 2;9(9)
Biomolecules 2019 Sep 2;9(9)
The combination of metformin and 2-deoxyglucose significantly inhibits cyst formation in miniature pigs with polycystic kidney disease.
Lian X, Wu X, Li Z, Zhang Y, Song K, Cai G, Li Q, Lin S, Chen X, Bai XY
British journal of pharmacology 2019 Mar;176(5):711-724
British journal of pharmacology 2019 Mar;176(5):711-724
Inhibition of hexokinases holds potential as treatment strategy for rheumatoid arthritis.
Song G, Lu Q, Fan H, Zhang X, Ge L, Tian R, Wang S, Feng T, Pan J, Feng J, Xiao Y, Yi X, Ren N, Wang L
Arthritis research & therapy 2019 Apr 3;21(1):87
Arthritis research & therapy 2019 Apr 3;21(1):87
The changes in glucose metabolism and cell proliferation in the kidneys of polycystic kidney disease mini-pig models.
Lian X, Zhao J, Wu X, Zhang Y, Li Q, Lin S, Bai XY, Chen X
Biochemical and biophysical research communications 2017 Jun 24;488(2):374-381
Biochemical and biophysical research communications 2017 Jun 24;488(2):374-381
Poly(ADP-ribose) polymerase regulates glycolytic activity in kidney proximal tubule epithelial cells.
Song H, Yoon SP, Kim J
Anatomy & cell biology 2016 Jun;49(2):79-87
Anatomy & cell biology 2016 Jun;49(2):79-87
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human brain tissue were subjected to SDS PAGE followed by western blot with 19662-1-AP(HK1 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human testis using 19662-1-AP(HK1 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Hexokinase 1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human Hexokinase 1. This antibody recognizes human,mouse,rat antigen. The Hexokinase 1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.