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Protein structure
MAP4K4
Mitogen-activated protein kinase kinase kinase kinase 4FLH21957, HGK, NIK
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| Novus Biologicals |  H00009448-M07 |
2 references | Monoclonal |
WB
EL
ICC
IHC
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| Proteintech Group | 55247-1-AP |
2 references | Polyclonal |
WB
EL
IP
IHC
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| Abnova Corporation | H00009448-M07 |
2 references | Monoclonal |
WB
EL
IHC
|
|
| GeneTex | GTX116008 |
1 references | Polyclonal |
WB
ICC
IHC
|
|
| Atlas Antibodies | HPA008476 |
1 references | Polyclonal |
WB
IHC
|
|
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