CABT-B105

antibody from Creative Diagnostics

Targeting: KDM5B CT31, JARID1B, PLU-1, PPP1R98, RBBP2H1A

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Antibody Data

Product number

CABT-B105

Provider

Creative Diagnostics

Product name

Anti-JARID1B monoclonal antibody, clone 5550

Antibody type

Monoclonal

Description

JARID1 (Jumonji AT-rich interactive domain 1) family members include two highly related genes JARID1A/RBP2/KDM5A and JARID1B/PLU1/KDM5B, and two less related genes JARID1C/SMCX/KDM5C and JARID1D/SMCY/KDM5D, on the X- and Y-chromosomes, respectively. The four JARID1 proteins and their orthologs in other organisms have been described as histone demethylases specific to methylated lysine 4 of histone H3 (H3K4). In the absence of JARID1A, JARID1B may be recruited to some of JARID1A target regions. High expression of JARID1B mRNA and protein has been found in all breast cancer cell lines examined, in cells cultured from primary breast cancers and in the invasive and in situ components in primary breast cancers. In breast cancer cells, JARID1B exhibits oncogenic properties and has been linked to repression of BRCA1 and other tumor suppressor genes.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

5550

Vial size

100_L

Storage

-20°C or 4°C