20248-1-AP

antibody from Proteintech Group

Targeting: ROCK2

Provider product page for 20248-1-AP

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [13]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [2]

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Product number: 20248-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#20248-1-AP, RRID:AB_10665551
Product name: ROCK2-Specific(C-term) antibody
Antibody type: Polyclonal
Description: KD/KO validated ROCK2-Specific(C-term) antibody (Cat. #20248-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

ROCK2 protein structure - 20248-1-AP shown in red.

Submitted references The distinct roles of myosin IIA and IIB under compression stress in nucleus pulposus cells.

Ke W, Wang B, Hua W, Song Y, Lu S, Luo R, Li G, Wang K, Liao Z, Xiang Q, Li S, Wu X, Zhang Y, Yang C
Cell proliferation 2021 Feb;54(2):e12987

Modulation of LPA1 receptor-mediated neuronal apoptosis by Saikosaponin-d: A target involved in depression.

Xu L, Su J, Guo L, Wang S, Deng X, Ma S
Neuropharmacology 2019 Sep 1;155:150-161

Activation of leukocyte immunoglobulin-like receptor B2 signaling pathway in cortical lesions of pediatric patients with focal cortical dysplasia type IIb and tuberous sclerosis complex.

Yue J, Zhang C, Shi X, Wei Y, Liu L, Liu S, Yang H
Brain & development 2019 Nov;41(10):829-838

Suppressing the Na(+)/H(+) exchanger 1: a new sight to treat depression.

Deng X, Ji Z, Xu B, Guo L, Xu L, Qin T, Feng L, Ma Z, Fu Q, Qu R, Quo Q, Ma S
Cell death & disease 2019 May 8;10(5):370

ROCK isoforms differentially modulate cancer cell motility by mechanosensing the substrate stiffness.

Peng Y, Chen Z, Chen Y, Li S, Jiang Y, Yang H, Wu C, You F, Zheng C, Zhu J, Tan Y, Qin X, Liu Y
Acta biomaterialia 2019 Apr 1;88:86-101

Biocompatible PEGylated Gold nanorods function As cytokinesis inhibitors to suppress angiogenesis.

Song H, Guo T, Zhao Z, Wei Y, Luo H, Weng W, Zhang R, Zhong M, Chen C, Su J, Shen W
Biomaterials 2018 Sep;178:23-35

MiR-455-3p suppresses renal fibrosis through repression of ROCK2 expression in diabetic nephropathy.

Wu J, Liu J, Ding Y, Zhu M, Lu K, Zhou J, Xie X, Xu Y, Shen X, Chen Y, Shao X, Zhu C
Biochemical and biophysical research communications 2018 Sep 5;503(2):977-983

Effects of chemerin/CMKLR1 in obesity-induced hypertension and potential mechanism.

Weng C, Shen Z, Li X, Jiang W, Peng L, Yuan H, Yang K, Wang J
American journal of translational research 2017;9(6):3096-3104

Lycopene Ameliorates Transplant Arteriosclerosis in Vascular Allograft Transplantation by Regulating the NO/cGMP Pathways and Rho-Associated Kinases Expression.

He Y, Xia P, Jin H, Zhang Y, Chen B, Xu Z
Oxidative medicine and cellular longevity 2016;2016:3128280

Activation of LILRB2 signal pathway in temporal lobe epilepsy patients and in a pilocarpine induced epilepsy model.

Yue J, Li W, Liang C, Chen B, Chen X, Wang L, Zang Z, Yu S, Liu S, Li S, Yang H
Experimental neurology 2016 Nov;285(Pt A):51-60

miR-125a-3p and miR-483-5p promote adipogenesis via suppressing the RhoA/ROCK1/ERK1/2 pathway in multiple symmetric lipomatosis.

Chen K, He H, Xie Y, Zhao L, Zhao S, Wan X, Yang W, Mo Z
Scientific reports 2015 Jul 7;5:11909

Induction of oligodendrocyte differentiation and in vitro myelination by inhibition of rho-associated kinase.

Pedraza CE, Taylor C, Pereira A, Seng M, Tham CS, Izrael M, Webb M
ASN neuro 2014 Jun 25;6(4)

Apocynin improves erectile function in diabetic rats through regulation of NADPH oxidase expression.

Li M, Zhuan L, Wang T, Rao K, Yang J, Yang J, Quan W, Liu J, Ye Z
The journal of sexual medicine 2012 Dec;9(12):3041-50

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 20248-1-AP(ROCK2-Specific antibody) at dilution of 1:400
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using ROCK2 antibody 20248-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human colon using 20248-1-AP(ROCK2-Specific antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human colon using 20248-1-AP(ROCK2-Specific antibody) at dilution of 1:100 (under 40x lens)
Sample type: tissue