NB100-138

Tan JT, Prosser HC, Dunn LL, Vanags LZ, Ridiandries A, Tsatralis T, Lecce L, Clayton ZE, Yuen SC, Robertson S, Lam YT, Celermajer DS, Ng MK, Bursill CA
Diabetes 2016 Oct;65(10):3091-103

Expressions of individual PHDs associate with good prognostic factors and increased proliferation in breast cancer patients.

Peurala E, Koivunen P, Bloigu R, Haapasaari KM, Jukkola-Vuorinen A
Breast cancer research and treatment 2012 May;133(1):179-88

Rapid microsatellite isolation from a butterfly by de novo transcriptome sequencing: performance and a comparison with AFLP-derived distances.

Mikheyev AS, Vo T, Wee B, Singer MC, Parmesan C
PloS one 2010 Jun 18;5(6):e11212

Extended ischemia prevents HIF1alpha degradation at reoxygenation by impairing prolyl-hydroxylation: role of Krebs cycle metabolites.

Serra-Pérez A, Planas AM, Núñez-O'Mara A, Berra E, García-Villoria J, Ribes A, Santalucía T
The Journal of biological chemistry 2010 Jun 11;285(24):18217-24

Mint3 enhances the activity of hypoxia-inducible factor-1 (HIF-1) in macrophages by suppressing the activity of factor inhibiting HIF-1.

Sakamoto T, Seiki M
The Journal of biological chemistry 2009 Oct 30;284(44):30350-9

Cellular oxygen sensing: Importins and exportins are mediators of intracellular localisation of prolyl-4-hydroxylases PHD1 and PHD2.

Steinhoff A, Pientka FK, Möckel S, Kettelhake A, Hartmann E, Köhler M, Depping R
Biochemical and biophysical research communications 2009 Oct 2;387(4):705-11

Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL.

Xie L, Xiao K, Whalen EJ, Forrester MT, Freeman RS, Fong G, Gygi SP, Lefkowitz RJ, Stamler JS
Science signaling 2009 Jul 7;2(78):ra33

Longitudinal and multimodal in vivo imaging of tumor hypoxia and its downstream molecular events.

Lehmann S, Stiehl DP, Honer M, Dominietto M, Keist R, Kotevic I, Wollenick K, Ametamey S, Wenger RH, Rudin M
Proceedings of the National Academy of Sciences of the United States of America 2009 Aug 18;106(33):14004-9

mAKAP compartmentalizes oxygen-dependent control of HIF-1alpha.

Wong W, Goehring AS, Kapiloff MS, Langeberg LK, Scott JD
Science signaling 2008 Dec 23;1(51):ra18

The new tumor-suppressor gene inhibitor of growth family member 4 (ING4) regulates the production of proangiogenic molecules by myeloma cells and suppresses hypoxia-inducible factor-1 alpha (HIF-1alpha) activity: involvement in myeloma-induced angiogenesis.

Colla S, Tagliaferri S, Morandi F, Lunghi P, Donofrio G, Martorana D, Mancini C, Lazzaretti M, Mazzera L, Ravanetti L, Bonomini S, Ferrari L, Miranda C, Ladetto M, Neri TM, Neri A, Greco A, Mangoni M, Bonati A, Rizzoli V, Giuliani N
Blood 2007 Dec 15;110(13):4464-75

Peroxisomal localization of hypoxia-inducible factors and hypoxia-inducible factor regulatory hydroxylases in primary rat hepatocytes exposed to hypoxia-reoxygenation.

Khan Z, Michalopoulos GK, Stolz DB
The American journal of pathology 2006 Oct;169(4):1251-69

Dynamic HIF1A regulation during human placental development.

Ietta F, Wu Y, Winter J, Xu J, Wang J, Post M, Caniggia I
Biology of reproduction 2006 Jul;75(1):112-21

Insulin-like growth factor receptor 1 (IGFR-1) is significantly associated with longer survival in non-small-cell lung cancer patients treated with gefitinib.

Cappuzzo F, Toschi L, Tallini G, Ceresoli GL, Domenichini I, Bartolini S, Finocchiaro G, Magrini E, Metro G, Cancellieri A, Trisolini R, Crino L, Bunn PA Jr, Santoro A, Franklin WA, Varella-Garcia M, Hirsch FR
Annals of oncology : official journal of the European Society for Medical Oncology 2006 Jul;17(7):1120-7

OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha.

Baek JH, Mahon PC, Oh J, Kelly B, Krishnamachary B, Pearson M, Chan DA, Giaccia AJ, Semenza GL
Molecular cell 2005 Feb 18;17(4):503-12

No comments: Submit comment

Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Western Blot: EGLN1/PHD2 Antibody [NB100-138] - Detection of Human PHD2 by Western Blot. Samples: Recombinant epitope-tagged PHD1, PHD2 or PHD3 (10 ng/lane) or whole cell lysate from HeLa cells, stained with rabbit anti-PHD2 used at 1 ug/ml.

Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Western Blot: EGLN1/PHD2 Antibody [NB100-138] - Analysis of human PHD2, using NB100-138. Samples: Recombinant FLAG-His-PHD1, PHD2 and PHD3 (10 ng/lane), HeLa whole cell lysate and MEFs.

Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Flow Cytometry: EGLN1/PHD2 Antibody [NB100-138] - Flow cytometric detection of PHD2, 10^6 Jurkat cells were fixed, permeabilized, and stained with 3.0 ug/ml anti-PHD2 in a 150 ul reaction.