Antibody data
- Antibody Data
- Antigen structure
- References [28]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- 13129-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13129-1-AP, RRID:AB_2155156
- Product name
- TrkB antibody
- Antibody type
- Polyclonal
- Description
- TrkB antibody (Cat. #13129-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat, pig and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat, Porcine
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Baihe Jizihuang Tang Ameliorates Chronic Unpredictable Mild Stress-Induced Depression-Like Behavior: Integrating Network Pharmacology and Brain-Gut Axis Evaluation.
Electroacupuncture Ameliorates Depressive-Like Behaviors in Poststroke Rats via Activating the tPA/BDNF/TrkB Pathway.
Injection of Anti-proBDNF Attenuates Hippocampal-Dependent Learning and Memory Dysfunction in Mice With Sepsis-Associated Encephalopathy.
Edaravone Alleviated Propofol-Induced Neurotoxicity in Developing Hippocampus by mBDNF/TrkB/PI3K Pathway.
Proteomic Analysis of Emodin Treatment in Neuropathic Pain Reveals Dysfunction of the Calcium Signaling Pathway.
Synergic Neuroprotection Between Ligusticum Chuanxiong Hort and Borneol Against Ischemic Stroke by Neurogenesis via Modulating Reactive Astrogliosis and Maintaining the Blood-Brain Barrier.
Jiedu Tongluo Granules Ameliorates Post-stroke Depression Rat Model via Regulating NMDAR/BDNF Signaling Pathway.
BDNF modulated KCC2 ubiquitylation in spinal cord dorsal horn of mice.
Tetrahydropalmatine Regulates BDNF through TrkB/CAM Interaction to Alleviate the Neurotoxicity Induced by Methamphetamine.
Dopamine receptor 2 downregulation and brain-derived neurotrophic factor upregulation in the paraventricular nucleus are correlated with brown adipose tissue thermogenesis in rats with bilateral substantia nigra lesions.
Role of the BDNF/TrkB/CREB signaling pathway in the cytotoxicity of bisphenol S in SK-N-SH cells.
Effects of Compound 511 on BDNF-TrkB Signaling in the Mice Ventral Tegmental Area in Morphine-Induced Conditioned Place Preference.
Water treadmill training protects the integrity of the blood-spinal cord barrier following SCI via the BDNF/TrkB-CREB signalling pathway.
Enhanced pro-BDNF-p75NTR pathway activity in denervated skeletal muscle.
Perinatal exposure to BDE-47 exacerbated autistic-like behaviors and impairments of dendritic development in a valproic acid-induced rat model of autism.
LMP1 promotes nasopharyngeal carcinoma metastasis through NTRK2-mediated anoikis resistance.
Alpha-synuclein is involved in manganese-induced spatial memory and synaptic plasticity impairments via TrkB/Akt/Fyn-mediated phosphorylation of NMDA receptors.
Bexarotene Improve Depression-Like Behaviour in Mice by Protecting Against Neuro-inflammation and Synaptic Damage.
Curcumin protects rat hippocampal neurons against pseudorabies virus by regulating the BDNF/TrkB pathway.
Catalpol Enhances Neurogenesis And Inhibits Apoptosis Of New Neurons Via BDNF, But Not The BDNF/Trkb Pathway.
Chaihu-Shugan-San and absorbed meranzin hydrate induce anti-atherosclerosis and behavioral improvements in high-fat diet ApoE-/- mice via anti-inflammatory and BDNF-TrkB pathway.
Hyperbaric oxygen therapy reduces apoptosis and dendritic/synaptic degeneration via the BDNF/TrkB signaling pathways in SCI rats.
OAB-14, a bexarotene derivative, improves Alzheimer's disease-related pathologies and cognitive impairments by increasing β-amyloid clearance in APP/PS1 mice.
Volatile Oil from Acorus gramineus Ameliorates the Injury Neurons in the Hippocampus of Amyloid Beta 1-42 Injected Mice.
Neuroprotective effect of 1-Deoxynojirimycin on cognitive impairment, β-amyloid deposition, and neuroinflammation in the SAMP8 mice.
Perinatal exposure to nonylphenol impairs dendritic outgrowth of cerebellar Purkinje cells in progeny.
Activation of BDNF-TrkB signaling pathway-regulated brain inflammation in pentylenetetrazole-induced seizures in zebrafish.
ERK1/2-mediated disruption of BDNF-TrkB signaling causes synaptic impairment contributing to fluoride-induced developmental neurotoxicity.
Zhu JP, Wu HY, Zi Y, Xia XB, Xie MZ, Yuan ZY
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5554363
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5554363
Electroacupuncture Ameliorates Depressive-Like Behaviors in Poststroke Rats via Activating the tPA/BDNF/TrkB Pathway.
Dong H, Qin YQ, Sun YC, Yao HJ, Cheng XK, Yu Y, Lu SS
Neuropsychiatric disease and treatment 2021;17:1057-1067
Neuropsychiatric disease and treatment 2021;17:1057-1067
Injection of Anti-proBDNF Attenuates Hippocampal-Dependent Learning and Memory Dysfunction in Mice With Sepsis-Associated Encephalopathy.
Cui YH, Zhou SF, Liu Y, Wang S, Li F, Dai RP, Hu ZL, Li CQ
Frontiers in neuroscience 2021;15:665757
Frontiers in neuroscience 2021;15:665757
Edaravone Alleviated Propofol-Induced Neurotoxicity in Developing Hippocampus by mBDNF/TrkB/PI3K Pathway.
Yang Y, Yi J, Pan M, Hu B, Duan H
Drug design, development and therapy 2021;15:1409-1422
Drug design, development and therapy 2021;15:1409-1422
Proteomic Analysis of Emodin Treatment in Neuropathic Pain Reveals Dysfunction of the Calcium Signaling Pathway.
Chen P, Lin D, Wang C, Song C, Wang W, Qu J, Wu Z
Journal of pain research 2021;14:613-622
Journal of pain research 2021;14:613-622
Synergic Neuroprotection Between Ligusticum Chuanxiong Hort and Borneol Against Ischemic Stroke by Neurogenesis via Modulating Reactive Astrogliosis and Maintaining the Blood-Brain Barrier.
Yu B, Yao Y, Zhang X, Ruan M, Zhang Z, Xu L, Liang T, Lu J
Frontiers in pharmacology 2021;12:666790
Frontiers in pharmacology 2021;12:666790
Jiedu Tongluo Granules Ameliorates Post-stroke Depression Rat Model via Regulating NMDAR/BDNF Signaling Pathway.
Zhao A, Ma B, Xu L, Yao M, Zhang Y, Xue B, Ren J, Chang D, Liu J
Frontiers in pharmacology 2021;12:662003
Frontiers in pharmacology 2021;12:662003
BDNF modulated KCC2 ubiquitylation in spinal cord dorsal horn of mice.
Ma JJ, Zhang TY, Diao XT, Yao L, Li YX, Suo ZW, Yang X, Hu XD, Liu YN
European journal of pharmacology 2021 Sep 5;906:174205
European journal of pharmacology 2021 Sep 5;906:174205
Tetrahydropalmatine Regulates BDNF through TrkB/CAM Interaction to Alleviate the Neurotoxicity Induced by Methamphetamine.
Liu L, Liu M, Zhao W, Zhao YL, Wang Y
ACS chemical neuroscience 2021 Sep 15;12(18):3373-3386
ACS chemical neuroscience 2021 Sep 15;12(18):3373-3386
Dopamine receptor 2 downregulation and brain-derived neurotrophic factor upregulation in the paraventricular nucleus are correlated with brown adipose tissue thermogenesis in rats with bilateral substantia nigra lesions.
Zhang Y, Zhou L, Lian H, Zhang Y, Tong S, Wang Z
Journal of chemical neuroanatomy 2021 Nov;117:102016
Journal of chemical neuroanatomy 2021 Nov;117:102016
Role of the BDNF/TrkB/CREB signaling pathway in the cytotoxicity of bisphenol S in SK-N-SH cells.
He QZ, Zhu BQ, Xu XN, Zeng HC
Journal of biochemical and molecular toxicology 2021 Jun;35(6):1-11
Journal of biochemical and molecular toxicology 2021 Jun;35(6):1-11
Effects of Compound 511 on BDNF-TrkB Signaling in the Mice Ventral Tegmental Area in Morphine-Induced Conditioned Place Preference.
Zhang H, Wang Q, Sun Q, Qin F, Nie D, Li Q, Gu Y, Jiang Y, Lu S, Lu Z
Cellular and molecular neurobiology 2021 Jul;41(5):961-975
Cellular and molecular neurobiology 2021 Jul;41(5):961-975
Water treadmill training protects the integrity of the blood-spinal cord barrier following SCI via the BDNF/TrkB-CREB signalling pathway.
Ying X, Xie Q, Yu X, Li S, Wu Q, Chen X, Yue J, Zhou K, Tu W, Jiang S
Neurochemistry international 2021 Feb;143:104945
Neurochemistry international 2021 Feb;143:104945
Enhanced pro-BDNF-p75NTR pathway activity in denervated skeletal muscle.
Aby K, Antony R, Eichholz M, Srinivasan R, Li Y
Life sciences 2021 Dec 1;286:120067
Life sciences 2021 Dec 1;286:120067
Perinatal exposure to BDE-47 exacerbated autistic-like behaviors and impairments of dendritic development in a valproic acid-induced rat model of autism.
Li Z, You M, Che X, Dai Y, Xu Y, Wang Y
Ecotoxicology and environmental safety 2021 Apr 1;212:112000
Ecotoxicology and environmental safety 2021 Apr 1;212:112000
LMP1 promotes nasopharyngeal carcinoma metastasis through NTRK2-mediated anoikis resistance.
Li Z, Zhou Z, Wu X, Zhou Q, Liao C, Liu Y, Li D, Shen L, Feng D, Yang L
American journal of cancer research 2020;10(7):2083-2099
American journal of cancer research 2020;10(7):2083-2099
Alpha-synuclein is involved in manganese-induced spatial memory and synaptic plasticity impairments via TrkB/Akt/Fyn-mediated phosphorylation of NMDA receptors.
Ma Z, Liu K, Li XR, Wang C, Liu C, Yan DY, Deng Y, Liu W, Xu B
Cell death & disease 2020 Oct 8;11(10):834
Cell death & disease 2020 Oct 8;11(10):834
Bexarotene Improve Depression-Like Behaviour in Mice by Protecting Against Neuro-inflammation and Synaptic Damage.
Yuan C, Dai C, Li Z, Zheng L, Zhao M, Dong S
Neurochemical research 2020 Jul;45(7):1500-1509
Neurochemical research 2020 Jul;45(7):1500-1509
Curcumin protects rat hippocampal neurons against pseudorabies virus by regulating the BDNF/TrkB pathway.
Yang B, Luo G, Zhang C, Feng L, Luo X, Gan L
Scientific reports 2020 Dec 17;10(1):22204
Scientific reports 2020 Dec 17;10(1):22204
Catalpol Enhances Neurogenesis And Inhibits Apoptosis Of New Neurons Via BDNF, But Not The BDNF/Trkb Pathway.
Zhu HF, Shao Y, Qin L, Wang JH, Feng S, Jiang YB, Wan D
Drug design, development and therapy 2019;13:4145-4157
Drug design, development and therapy 2019;13:4145-4157
Chaihu-Shugan-San and absorbed meranzin hydrate induce anti-atherosclerosis and behavioral improvements in high-fat diet ApoE-/- mice via anti-inflammatory and BDNF-TrkB pathway.
Li L, Yu AL, Wang ZL, Chen K, Zheng W, Zhou JJ, Xie Q, Yan HB, Ren P, Huang X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jul;115:108893
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jul;115:108893
Hyperbaric oxygen therapy reduces apoptosis and dendritic/synaptic degeneration via the BDNF/TrkB signaling pathways in SCI rats.
Ying X, Tu W, Li S, Wu Q, Chen X, Zhou Y, Hu J, Yang G, Jiang S
Life sciences 2019 Jul 15;229:187-199
Life sciences 2019 Jul 15;229:187-199
OAB-14, a bexarotene derivative, improves Alzheimer's disease-related pathologies and cognitive impairments by increasing β-amyloid clearance in APP/PS1 mice.
Yuan C, Guo X, Zhou Q, Du F, Jiang W, Zhou X, Liu P, Chi T, Ji X, Gao J, Chen C, Lang H, Xu J, Liu D, Yang Y, Qiu S, Tang X, Chen G, Zou L
Biochimica et biophysica acta. Molecular basis of disease 2019 Jan;1865(1):161-180
Biochimica et biophysica acta. Molecular basis of disease 2019 Jan;1865(1):161-180
Volatile Oil from Acorus gramineus Ameliorates the Injury Neurons in the Hippocampus of Amyloid Beta 1-42 Injected Mice.
Gao N, Liu H, Li S, Tu X, Tian S, Liu J, Li G, Ma Y
Anatomical record (Hoboken, N.J. : 2007) 2019 Dec;302(12):2261-2270
Anatomical record (Hoboken, N.J. : 2007) 2019 Dec;302(12):2261-2270
Neuroprotective effect of 1-Deoxynojirimycin on cognitive impairment, β-amyloid deposition, and neuroinflammation in the SAMP8 mice.
Chen W, Liang T, Zuo W, Wu X, Shen Z, Wang F, Li C, Zheng Y, Peng G
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Oct;106:92-97
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Oct;106:92-97
Perinatal exposure to nonylphenol impairs dendritic outgrowth of cerebellar Purkinje cells in progeny.
You M, Gu W, Li M, Qiu Z, Li S, Jiang Z, Yao D, Xu Y, Wang Y
Chemosphere 2018 Nov;211:758-766
Chemosphere 2018 Nov;211:758-766
Activation of BDNF-TrkB signaling pathway-regulated brain inflammation in pentylenetetrazole-induced seizures in zebrafish.
Jin M, Sheng W, Han L, He Q, Ji X, Liu K
Fish & shellfish immunology 2018 Dec;83:26-36
Fish & shellfish immunology 2018 Dec;83:26-36
ERK1/2-mediated disruption of BDNF-TrkB signaling causes synaptic impairment contributing to fluoride-induced developmental neurotoxicity.
Chen J, Niu Q, Xia T, Zhou G, Li P, Zhao Q, Xu C, Dong L, Zhang S, Wang A
Toxicology 2018 Dec 1;410:222-230
Toxicology 2018 Dec 1;410:222-230
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The TrkB antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human TrkB. This antibody recognizes human,mouse,rat antigen. The TrkB antibody has been validated for the following applications: ELISA, WB analysis.