APR02059G

antibody from Leading Biology

Targeting: CDK12 CRK7, CRKR, CRKRS, KIAA0904

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

APR02059G

Provider

Leading Biology

Product name

CDK12 / CRKRS Antibody (C-Terminus)

Antibody type

Polyclonal

Description

Cyclin-dependent kinase that phosphorylates the C- terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.

Reactivity

Human, Mouse, Canine, Hamster, Rabbit, Simian

Host

Rabbit

Storage

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.