4403

antibody from Cell Signaling Technology, Inc

Targeting: TNFRSF12A CD266, FN14, TweakR

Western blot (Data presented on provider website)

Immunoprecipitation (Data presented on provider website)

Antibody Data

Product number

4403

Provider

Cell Signaling Technology, Inc

Proper citation

Cell Signaling Technology Cat#4403, RRID:AB_10693941

Product name

TWEAK Receptor/Fn14 Antibody

Antibody type

Polyclonal

Reactivity

Human, Mouse, Rat, Bovine

Host

Rabbit

Storage

-20°C

References

Submitted references

TWEAK induces apoptosis through a death-signaling complex comprising receptor-interacting protein 1 (RIP1), Fas-associated death domain (FADD), and caspase-8.

Ikner A, Ashkenazi A
The Journal of biological chemistry 2011 Jun 17;286(24):21546-54

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Ligand activation of peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) attenuates carbon tetrachloride hepatotoxicity by downregulating proinflammatory gene expression.

Shan W, Palkar PS, Murray IA, McDevitt EI, Kennett MJ, Kang BH, Isom HC, Perdew GH, Gonzalez FJ, Peters JM
Toxicological sciences : an official journal of the Society of Toxicology 2008 Oct;105(2):418-28

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TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFalpha.

Vince JE, Chau D, Callus B, Wong WW, Hawkins CJ, Schneider P, McKinlay M, Benetatos CA, Condon SM, Chunduru SK, Yeoh G, Brink R, Vaux DL, Silke J
The Journal of cell biology 2008 Jul 14;182(1):171-84

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Fibroblast growth factor inducible 14 (Fn14) is required for the expression of myogenic regulatory factors and differentiation of myoblasts into myotubes. Evidence for TWEAK-independent functions of Fn14 during myogenesis.

Dogra C, Hall SL, Wedhas N, Linkhart TA, Kumar A
The Journal of biological chemistry 2007 May 18;282(20):15000-10