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Immunocytochemistry
Other assayAntibody data
- Antibody Data
- Antigen structure
- References [9]
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- Other assay [1]
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- Product number
- V3050 - Provider product page
- Provider
- NSJ Bioreagents
- Product name
- GITR Antibody (TNFRSF18)
- Antibody type
- Monoclonal
- Antigen
- Mouse CD25+ CD4+ T cells were used as the immunogen for the GITR antibody.
- Description
- Protein G purified antibody
- Reactivity
- Mouse
- Host
- Rat
- Conjugate
- Unconjugated
- Antibody clone number
- DTA-1
- Vial size
- 20 µg, 100 µg (with sodium azide), 100 µg (without sodium azide), 7 ml (prediluted for IHC use, if applicable)
- Storage
- Store the GITR antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Submitted references Glucocorticoid-induced tumor necrosis factor receptor-related protein co-stimulation facilitates tumor regression by inducing IL-9-producing helper T cells.
GITR subverts Foxp3(+) Tregs to boost Th9 immunity through regulation of histone acetylation.
Authentic GITR Signaling Fails To Induce Tumor Regression unless Foxp3+ Regulatory T Cells Are Depleted.
The combination of a novel immunomodulator with a regulatory T cell suppressing antibody (DTA-1) regress advanced stage B16F10 solid tumor by repolarizing tumor associated macrophages in situ.
GITR intrinsically sustains early type 1 and late follicular helper CD4 T cell accumulation to control a chronic viral infection.
GITR agonist enhances vaccination responses in lung cancer.
OX40 engagement depletes intratumoral Tregs via activating FcγRs, leading to antitumor efficacy.
Suppression of Tregs by anti-glucocorticoid induced TNF receptor antibody enhances the antitumor immunity of interferon-α gene therapy for pancreatic cancer.
Anaphylaxis caused by repetitive doses of a GITR agonist monoclonal antibody in mice.
Kim IK, Kim BS, Koh CH, Seok JW, Park JS, Shin KS, Bae EA, Lee GE, Jeon H, Cho J, Jung Y, Han D, Kwon BS, Lee HY, Chung Y, Kang CY
Nature medicine 2015 Sep;21(9):1010-7
Nature medicine 2015 Sep;21(9):1010-7
GITR subverts Foxp3(+) Tregs to boost Th9 immunity through regulation of histone acetylation.
Xiao X, Shi X, Fan Y, Zhang X, Wu M, Lan P, Minze L, Fu YX, Ghobrial RM, Liu W, Li XC
Nature communications 2015 Sep 14;6:8266
Nature communications 2015 Sep 14;6:8266
Authentic GITR Signaling Fails To Induce Tumor Regression unless Foxp3+ Regulatory T Cells Are Depleted.
Kim YH, Shin SM, Choi BK, Oh HS, Kim CH, Lee SJ, Kim KH, Lee DG, Park SH, Kwon BS
Journal of immunology (Baltimore, Md. : 1950) 2015 Nov 15;195(10):4721-9
Journal of immunology (Baltimore, Md. : 1950) 2015 Nov 15;195(10):4721-9
The combination of a novel immunomodulator with a regulatory T cell suppressing antibody (DTA-1) regress advanced stage B16F10 solid tumor by repolarizing tumor associated macrophages in situ.
Banerjee S, Halder K, Ghosh S, Bose A, Majumdar S
Oncoimmunology 2015 Mar;4(3):e995559
Oncoimmunology 2015 Mar;4(3):e995559
GITR intrinsically sustains early type 1 and late follicular helper CD4 T cell accumulation to control a chronic viral infection.
Clouthier DL, Zhou AC, Wortzman ME, Luft O, Levy GA, Watts TH
PLoS pathogens 2015 Jan;11(1):e1004517
PLoS pathogens 2015 Jan;11(1):e1004517
GITR agonist enhances vaccination responses in lung cancer.
Zhu LX, Davoodi M, Srivastava MK, Kachroo P, Lee JM, St John M, Harris-White M, Huang M, Strieter RM, Dubinett S, Sharma S
Oncoimmunology 2015 Apr;4(4):e992237
Oncoimmunology 2015 Apr;4(4):e992237
OX40 engagement depletes intratumoral Tregs via activating FcγRs, leading to antitumor efficacy.
Bulliard Y, Jolicoeur R, Zhang J, Dranoff G, Wilson NS, Brogdon JL
Immunology and cell biology 2014 Jul;92(6):475-80
Immunology and cell biology 2014 Jul;92(6):475-80
Suppression of Tregs by anti-glucocorticoid induced TNF receptor antibody enhances the antitumor immunity of interferon-α gene therapy for pancreatic cancer.
Aida K, Miyakawa R, Suzuki K, Narumi K, Udagawa T, Yamamoto Y, Chikaraishi T, Yoshida T, Aoki K
Cancer science 2014 Feb;105(2):159-67
Cancer science 2014 Feb;105(2):159-67
Anaphylaxis caused by repetitive doses of a GITR agonist monoclonal antibody in mice.
Murphy JT, Burey AP, Beebe AM, Gu D, Presta LG, Merghoub T, Wolchok JD
Blood 2014 Apr 3;123(14):2172-80
Blood 2014 Apr 3;123(14):2172-80
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Supportive validation
- Submitted by
- NSJ Bioreagents (provider)
- Main image
- Experimental details
- SDS-PAGE Analysis of Purified, BSA-Free GITR Antibody (clone DTA-1). Confirmation of Integrity and Purity of the Antibody.
