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Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [1]
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- Validations
- Flow cytometry [1]
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- Product number
- 311602 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#311602, RRID:AB_314885
- Product name
- Purified anti-human CD357 (GITR)
- Antibody type
- Monoclonal
- Antigen
- GITR
- Description
- GITR (glucocorticoid-induced TNF receptor family-regulated gene) is a 25 kD TNF receptor superfamily member (also known as AITR and TNFRSF18). GITR is expressed on activated lymphocytes and is upregulated by T cell receptor engagement. The cytoplasmic domain of GITR is homologous to CD40, 4-1BB and CD27 and has been shown to interact with TRAF 1-3, but not TRAF 5 or 6. GITR signaling has been shown to regulate T cell proliferation and TCR-mediated apoptosis, and to break immunological self-tolerance. GITR binds GITRL and is involved in the development of regulatory T cells and to regulate the activity of Th1 subsets.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4°C.
Submitted references Human glucocorticoid-induced TNF receptor ligand regulates its signaling activity through multiple oligomerization states.
Zhou Z, Song X, Berezov A, Zhang G, Li Y, Zhang H, Murali R, Li B, Greene MI
Proceedings of the National Academy of Sciences of the United States of America 2008 Apr 8;105(14):5465-70
Proceedings of the National Academy of Sciences of the United States of America 2008 Apr 8;105(14):5465-70
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Supportive validation
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- BioLegend (provider)
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- Experimental details
- Human T lymphoma cell line HUT-78 stained with purified 621, followed by biotinylated anti-mouse IgG and Sav-PE
- Conjugate
- Unconjugated
