Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- BS60048 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- SNRPD3 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- A synthetic peptide corresponding to residues in Human SNRPD3.
- Description
- U1, U2, U4, U5, U6 and U7 are small nuclear ribonucleoproteins (snRNPs) that comprise the spliceosome in eukaryotes. Each UsnRNP contains common Sm proteins B/B', D1, D2, D3, E, F and G. The Sm proteins pair up as D1-D2, B/B'-D3 and E-F-G to form RNA-free hetero-oligomers in the cytoplasm. Sm proteins aid in the cytoplasmic construction of the UsnRNPs by binding to a conserved Sm site on UsnRNA and forming a stable snRNP core complex. Sm D1, D2 and D3 are present in U1, U2, U4/5 and U5 but not U7 snRNPs in human and mouse cells. U7 snRNPs contain Lsm10, an Sm D1-like protein. Autoantibodies produced in patients suffering from systemic lupus erythematosus react predominantly with Sm B/B', D1 and D3. The major linear epitope of these autoantibodies includes the C-terminal RG dipeptide repeats found in Sm D1 and D3.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- Western blot (WB) analysis of SNRPD3 pAb at 1:500 dilutionLane1:Jurkat whole cell lysateLane2:Mouse brain tissue lysateLane3:H9C2 whole cell lysate