Antibody data

Product number
BS60048 - Provider product page
Provider
Bioworld Technology, Inc
Product name
SNRPD3 polyclonal antibody
Antibody type
Polyclonal
Antigen
A synthetic peptide corresponding to residues in Human SNRPD3.
Description
U1, U2, U4, U5, U6 and U7 are small nuclear ribonucleoproteins (snRNPs) that comprise the spliceosome in eukaryotes. Each UsnRNP contains common Sm proteins B/B', D1, D2, D3, E, F and G. The Sm proteins pair up as D1-D2, B/B'-D3 and E-F-G to form RNA-free hetero-oligomers in the cytoplasm. Sm proteins aid in the cytoplasmic construction of the UsnRNPs by binding to a conserved Sm site on UsnRNA and forming a stable snRNP core complex. Sm D1, D2 and D3 are present in U1, U2, U4/5 and U5 but not U7 snRNPs in human and mouse cells. U7 snRNPs contain Lsm10, an Sm D1-like protein. Autoantibodies produced in patients suffering from systemic lupus erythematosus react predominantly with Sm B/B', D1 and D3. The major linear epitope of these autoantibodies includes the C-terminal RG dipeptide repeats found in Sm D1 and D3.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
SNRPD3 protein structure - BS60048 shown in red.