AP0783

antibody from Bioworld Technology, Inc

Targeting: UVRAG VPS38

Western blot (Data presented on provider website)

Antibody Data

Product number

AP0783

Provider

Bioworld Technology, Inc

Proper citation

Bioworld Technology Cat#AP0783, RRID:AB_2797429

Product name

UVRAG polyclonal antibody

Antibody type

Polyclonal

Antigen

A synthetic peptide corresponding to residues in Human UVRAG.

Description

UVRAG (UV radiation resistance-associated gene), also known as p63 or DHTX, is a 699 amino acid cytoplasmic protein. UVRAG has been shown to activate the BECN1/PI 3-kinase complex, which promotes autophagy. Autophagy is the degradation of cellular proteins in the lysosomes, and when this pathway is suppressed, cell growth is deregulated. Mutations in the gene encoding UVRAG have been associated with colon cancer, suggesting that UVRAG is also involved in suppressing the proliferation and tumorigenicity of human colon cancer cells. UVRAG has been found to complement the ultraviolet sensitivity of xeroderma pigmentosum group C cells.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Isotype

IgG

Vial size

100ul

Concentration

1 mg/ml

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.