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- Antigen structure
- References [29]
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- Immunocytochemistry [1]
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- Product number
- 19655-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- SIRT2-Specific antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SIRT2-Specific antibody (Cat. #19655-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Oligodendrocytes enhance axonal energy metabolism by deacetylation of mitochondrial proteins through transcellular delivery of SIRT2.
PHD Finger Protein 19 Promotes Cardiac Hypertrophy via Epigenetically Regulating SIRT2.
SIRT2-knockdown rescues GARS-induced Charcot-Marie-Tooth neuropathy.
SIRT2 promotes murine melanoma progression through natural killer cell inhibition.
20-HETE synthesis inhibition attenuates traumatic brain injury-induced mitochondrial dysfunction and neuronal apoptosis via the SIRT1/PGC-1α pathway: A translational study.
Association of T2285C polymorphism in PARP1 gene coding region with its expression, activity and NSCLC risk along with prognosis.
TSP50 promotes hepatocyte proliferation and tumour formation by activating glucose-6-phosphate dehydrogenase (G6PD).
A translational program that suppresses metabolism to shield the genome.
SIRT2 protects peripheral neurons from cisplatin-induced injury by enhancing nucleotide excision repair.
Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism.
Sirtuin 2 Inhibition Attenuates Sevoflurane-Induced Learning and Memory Deficits in Developing Rats via Modulating Microglial Activation.
Context-Dependent Roles for SIRT2 and SIRT3 in Tumor Development Upon Calorie Restriction or High Fat Diet.
Comprehensive Analysis of Expression and Prognostic Value of Sirtuins in Ovarian Cancer.
SIRT2 functions in aging, autophagy, and apoptosis in post-maturation bovine oocytes.
PGC-1α acts as an mediator of Sirtuin2 to protect annulus fibrosus from apoptosis induced by oxidative stress through restraining mitophagy.
SIRT2 Inhibition Results in Meiotic Arrest, Mitochondrial Dysfunction, and Disturbance of Redox Homeostasis during Bovine Oocyte Maturation.
Key Role of Microtubule and Its Acetylation in a Zinc Oxide Nanoparticle-Mediated Lysosome-Autophagy System.
RAB35 depletion affects spindle formation and actin-based spindle migration in mouse oocyte meiosis.
Sirtuin 2-mediated deacetylation of cyclin-dependent kinase 9 promotes STAT1 signaling in type I interferon responses.
Rab23/Kif17 regulate meiotic progression in oocytes by modulating tubulin acetylation and actin dynamics.
SIRT2 knockout exacerbates insulin resistance in high fat-fed mice.
Kif18a regulates Sirt2-mediated tubulin acetylation for spindle organization during mouse oocyte meiosis.
NQO1 regulates mitotic progression and response to mitotic stress through modulating SIRT2 activity.
HDAC6 inhibition protects cardiomyocytes against doxorubicin-induced acute damage by improving α-tubulin acetylation.
Overexpression of FOXQ1 enhances anti-senescence and migration effects of human umbilical cord mesenchymal stem cells in vitro and in vivo.
Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling.
Downregulation of NAD-Dependent Deacetylase SIRT2 Protects Mouse Brain Against Ischemic Stroke.
Loss of NAD-Dependent Protein Deacetylase Sirtuin-2 Alters Mitochondrial Protein Acetylation and Dysregulates Mitophagy.
RCCD1 depletion attenuates TGF-β-induced EMT and cell migration by stabilizing cytoskeletal microtubules in NSCLC cells.
Chamberlain KA, Huang N, Xie Y, LiCausi F, Li S, Li Y, Sheng ZH
Neuron 2021 Nov 3;109(21):3456-3472.e8
Neuron 2021 Nov 3;109(21):3456-3472.e8
PHD Finger Protein 19 Promotes Cardiac Hypertrophy via Epigenetically Regulating SIRT2.
Gu W, Cheng Y, Wang S, Sun T, Li Z
Cardiovascular toxicology 2021 Jun;21(6):451-461
Cardiovascular toxicology 2021 Jun;21(6):451-461
SIRT2-knockdown rescues GARS-induced Charcot-Marie-Tooth neuropathy.
Zhao Y, Xie L, Shen C, Qi Q, Qin Y, Xing J, Zhou D, Qi Y, Yan Z, Lin X, Dai R, Lin J, Yu W
Aging cell 2021 Jun;20(6):e13391
Aging cell 2021 Jun;20(6):e13391
SIRT2 promotes murine melanoma progression through natural killer cell inhibition.
Zhang M, Acklin S, Gillenwater J, Du W, Patra M, Yu H, Xu B, Yu J, Xia F
Scientific reports 2021 Jun 21;11(1):12988
Scientific reports 2021 Jun 21;11(1):12988
20-HETE synthesis inhibition attenuates traumatic brain injury-induced mitochondrial dysfunction and neuronal apoptosis via the SIRT1/PGC-1α pathway: A translational study.
Cui W, Wu X, Shi Y, Guo W, Luo J, Liu H, Zheng L, Du Y, Wang P, Wang Q, Feng D, Ge S, Qu Y
Cell proliferation 2021 Feb;54(2):e12964
Cell proliferation 2021 Feb;54(2):e12964
Association of T2285C polymorphism in PARP1 gene coding region with its expression, activity and NSCLC risk along with prognosis.
Wang Y, Xia XB, Tang HZ, Cai JR, Shi XK, Ji HX, Yan XN, Xu T
Mutagenesis 2021 Aug 27;36(4):281-293
Mutagenesis 2021 Aug 27;36(4):281-293
TSP50 promotes hepatocyte proliferation and tumour formation by activating glucose-6-phosphate dehydrogenase (G6PD).
Zhang X, Gao F, Ai H, Wang S, Song Z, Zheng L, Wang G, Sun Y, Bao Y
Cell proliferation 2021 Apr;54(4):e13015
Cell proliferation 2021 Apr;54(4):e13015
A translational program that suppresses metabolism to shield the genome.
Balukoff NC, Ho JJD, Theodoridis PR, Wang M, Bokros M, Llanio LM, Krieger JR, Schatz JH, Lee S
Nature communications 2020 Nov 13;11(1):5755
Nature communications 2020 Nov 13;11(1):5755
SIRT2 protects peripheral neurons from cisplatin-induced injury by enhancing nucleotide excision repair.
Zhang M, Du W, Acklin S, Jin S, Xia F
The Journal of clinical investigation 2020 Jun 1;130(6):2953-2965
The Journal of clinical investigation 2020 Jun 1;130(6):2953-2965
Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism.
Fu Y, Sun Y, Wang M, Hou Y, Huang W, Zhou D, Wang Z, Yang S, Tang W, Zhen J, Li Y, Wang X, Liu M, Zhang Y, Wang B, Liu G, Yu X, Sun J, Zhang C, Yi F
Cell metabolism 2020 Dec 1;32(6):1052-1062.e8
Cell metabolism 2020 Dec 1;32(6):1052-1062.e8
Sirtuin 2 Inhibition Attenuates Sevoflurane-Induced Learning and Memory Deficits in Developing Rats via Modulating Microglial Activation.
Wu Z, Zhang Y, Zhang Y, Zhao P
Cellular and molecular neurobiology 2020 Apr;40(3):437-446
Cellular and molecular neurobiology 2020 Apr;40(3):437-446
Context-Dependent Roles for SIRT2 and SIRT3 in Tumor Development Upon Calorie Restriction or High Fat Diet.
Ahmed MA, O'Callaghan C, Chang ED, Jiang H, Vassilopoulos A
Frontiers in oncology 2019;9:1462
Frontiers in oncology 2019;9:1462
Comprehensive Analysis of Expression and Prognostic Value of Sirtuins in Ovarian Cancer.
Sun X, Wang S, Li Q
Frontiers in genetics 2019;10:879
Frontiers in genetics 2019;10:879
SIRT2 functions in aging, autophagy, and apoptosis in post-maturation bovine oocytes.
Xu D, Jiang X, He H, Liu D, Yang L, Chen H, Wu L, Geng G, Li Q
Life sciences 2019 Sep 1;232:116639
Life sciences 2019 Sep 1;232:116639
PGC-1α acts as an mediator of Sirtuin2 to protect annulus fibrosus from apoptosis induced by oxidative stress through restraining mitophagy.
Xu WN, Yang RZ, Zheng HL, Yu W, Zheng XF, Li B, Jiang SD, Jiang LS
International journal of biological macromolecules 2019 Sep 1;136:1007-1017
International journal of biological macromolecules 2019 Sep 1;136:1007-1017
SIRT2 Inhibition Results in Meiotic Arrest, Mitochondrial Dysfunction, and Disturbance of Redox Homeostasis during Bovine Oocyte Maturation.
Xu D, Wu L, Jiang X, Yang L, Cheng J, Chen H, Hua R, Geng G, Yang L, Li Q
International journal of molecular sciences 2019 Mar 18;20(6)
International journal of molecular sciences 2019 Mar 18;20(6)
Key Role of Microtubule and Its Acetylation in a Zinc Oxide Nanoparticle-Mediated Lysosome-Autophagy System.
Liu J, Kang Y, Yin S, Chen A, Wu J, Liang H, Shao L
Small (Weinheim an der Bergstrasse, Germany) 2019 Jun;15(25):e1901073
Small (Weinheim an der Bergstrasse, Germany) 2019 Jun;15(25):e1901073
RAB35 depletion affects spindle formation and actin-based spindle migration in mouse oocyte meiosis.
Zhang Y, Wan X, Wang HH, Pan MH, Pan ZN, Sun SC
Molecular human reproduction 2019 Jul 1;25(7):359-372
Molecular human reproduction 2019 Jul 1;25(7):359-372
Sirtuin 2-mediated deacetylation of cyclin-dependent kinase 9 promotes STAT1 signaling in type I interferon responses.
Kosciuczuk EM, Mehrotra S, Saleiro D, Kroczynska B, Majchrzak-Kita B, Lisowski P, Driehaus C, Rogalska A, Turner A, Lienhoop T, Gius D, Fish EN, Vassilopoulos A, Platanias LC
The Journal of biological chemistry 2019 Jan 18;294(3):827-837
The Journal of biological chemistry 2019 Jan 18;294(3):827-837
Rab23/Kif17 regulate meiotic progression in oocytes by modulating tubulin acetylation and actin dynamics.
Wang HH, Zhang Y, Tang F, Pan MH, Wan X, Li XH, Sun SC
Development (Cambridge, England) 2019 Feb 4;146(3)
Development (Cambridge, England) 2019 Feb 4;146(3)
SIRT2 knockout exacerbates insulin resistance in high fat-fed mice.
Lantier L, Williams AS, Hughey CC, Bracy DP, James FD, Ansari MA, Gius D, Wasserman DH
PloS one 2018;13(12):e0208634
PloS one 2018;13(12):e0208634
Kif18a regulates Sirt2-mediated tubulin acetylation for spindle organization during mouse oocyte meiosis.
Tang F, Pan MH, Wan X, Lu Y, Zhang Y, Sun SC
Cell division 2018;13:9
Cell division 2018;13:9
NQO1 regulates mitotic progression and response to mitotic stress through modulating SIRT2 activity.
Kang HJ, Song HY, Ahmed MA, Guo Y, Zhang M, Chen C, Cristofanilli M, Horiuchi D, Vassilopoulos A
Free radical biology & medicine 2018 Oct;126:358-371
Free radical biology & medicine 2018 Oct;126:358-371
HDAC6 inhibition protects cardiomyocytes against doxorubicin-induced acute damage by improving α-tubulin acetylation.
Song R, Yang Y, Lei H, Wang G, Huang Y, Xue W, Wang Y, Yao L, Zhu Y
Journal of molecular and cellular cardiology 2018 Nov;124:58-69
Journal of molecular and cellular cardiology 2018 Nov;124:58-69
Overexpression of FOXQ1 enhances anti-senescence and migration effects of human umbilical cord mesenchymal stem cells in vitro and in vivo.
Zhang T, Wang P, Liu Y, Zhou J, Shi Z, Cheng K, Huang T, Wang X, Yang GL, Yang B, Ma S, Guan F
Cell and tissue research 2018 Aug;373(2):379-393
Cell and tissue research 2018 Aug;373(2):379-393
Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling.
Liu M, Liang K, Zhen J, Zhou M, Wang X, Wang Z, Wei X, Zhang Y, Sun Y, Zhou Z, Su H, Zhang C, Li N, Gao C, Peng J, Yi F
Nature communications 2017 Sep 4;8(1):413
Nature communications 2017 Sep 4;8(1):413
Downregulation of NAD-Dependent Deacetylase SIRT2 Protects Mouse Brain Against Ischemic Stroke.
Xie XQ, Zhang P, Tian B, Chen XQ
Molecular neurobiology 2017 Nov;54(9):7251-7261
Molecular neurobiology 2017 Nov;54(9):7251-7261
Loss of NAD-Dependent Protein Deacetylase Sirtuin-2 Alters Mitochondrial Protein Acetylation and Dysregulates Mitophagy.
Liu G, Park SH, Imbesi M, Nathan WJ, Zou X, Zhu Y, Jiang H, Parisiadou L, Gius D
Antioxidants & redox signaling 2017 May 20;26(15):849-863
Antioxidants & redox signaling 2017 May 20;26(15):849-863
RCCD1 depletion attenuates TGF-β-induced EMT and cell migration by stabilizing cytoskeletal microtubules in NSCLC cells.
Wu J, He Z, Yang XM, Li KL, Wang DL, Sun FL
Cancer letters 2017 Aug 1;400:18-29
Cancer letters 2017 Aug 1;400:18-29
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SIRT2-Specific antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human SIRT2-Specific. This antibody recognizes human, mouse, rat antigen. The SIRT2-Specific antibody has been validated for the following applications: ELISA, IHC, WB, IF analysis.
