BS3402

antibody from Bioworld Technology, Inc

Targeting: SPTBN1

Western blot (Data presented on provider website)

Antibody Data

Product number

BS3402

Provider

Bioworld Technology, Inc

Proper citation

Bioworld Technology Cat#BS3402, RRID:AB_1662262

Product name

Spectrin ÉÇ II (M687) polyclonal antibody

Antibody type

Polyclonal

Antigen

Synthetic peptide, corresponding to amino acids 650-700 of Human Spectrin ÉÇ II.

Description

Spectrin is an actin binding protein that is a major component of the cytoskeletal superstructure of the erythrocyte plasma membrane. Spectrins function as membrane organizers and stabilizers by forming dimers, tetramers and higher polymers. Spectrin Ï« I and spectrin ÉÇ I are present in erythrocytes, whereas spectrin Ï« II (also designated fodrin Ï«) and spectrin ÉÇ II (also designated fodrin ÉÇ) are present in other somatic cells. The spectrin tetramers in erythrocytes act as barriers to lateral diffusion, but spectrin dimers seem to lack this function. Defects in the SPTB gene encoding spectrin ÉÇ I are the cause of spherocytosis type I (SPH1), a disorder characterized by severe hemolytic anemia. Another disorder due to defects of SPTB is called elliptocytosis or elliptocytosis 3 (EL3). The human SPTB gene maps to chromosome 14q22-q23.2 and encodes the 2,137 amino acid, 246 kDa erythroid form of ÉÇ-spectrin.

Reactivity

Human, Mouse

Host

Rabbit

Isotype

IgG

Vial size

100ul

Concentration

1 mg/ml

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.