Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS60748 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- PPP4R1 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- A synthetic peptide corresponding to residues in Human PPP4R1
- Description
- In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions, including division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/threonine protein phosphatases. In general, the protein phosphatase (PP) holoenzyme is a trimeric complex composed of a regulatory subunit, a variable subunit and a catalytic subunit. Protein phosphatase 4 (PP4) is comprised of different regulatory subunits that exhibit mutually exclusive interactions with the PP4 catalytic subunit, PPX. PP4R1, also known as PPP4R1 or PP4(Rmeg), is regulatory subunit 1 of protein phosphatase 4. It is ubiquitously expressed and can form a binary complex with PPX that negatively regulates the activity of HDAC3. PP4 is required for cell growth, nucleation and the stabilization of microtubules during cell division. This suggests that PP4R1 participates in the regulation of mitosis.
- Reactivity
- Human
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- Western blot (WB) analysis of PPP4R1 pAb at 1:500 dilutionLane1:HEK293T whole cell lysateLane2:MCF-7 whole cell lysate