BS60194

antibody from Bioworld Technology, Inc
Targeting: SCG5 7B2, SGNE1, SgV
Provider product page for BS60194

Antibody data

Product number
BS60194 - Provider product page
Provider
Bioworld Technology, Inc
Product name
SCG5 polyclonal antibody
Antibody type
Polyclonal
Antigen
A synthetic peptide corresponding to residues in Human SCG5.
Description
Sg V (secretogranin V), also known as SCG5, SGNE1 or 7B2, is a 212 amino acid protein that is secreted by endocrine and neuroendocrine secretory granules and belongs to the 7B2 family. Existing as two alternatively spliced isoforms, Sg V interacts with PC2 and, via this interaction, functions as a molecular chaperone for PC2, effectively preventing its premature activation in regulated secretory pathways. More specifically, Sg V binds to PC2 and facilitates its transport from the endoplasmic reticulum to secretory compartments, thus allowing PC2 to be cleaved and activated during the correct phase of the regulated secretory pathway. Sg V is subject to post-translational sulfation on specific tyrosine residues and is underexpressed in medulloblastomas, suggesting a role in tumor suppression. The gene encoding Sg V maps to human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome.
Reactivity
Human
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
SCG5 protein structure - BS60194 shown in red.