Antibody data

Product number
BS60695 - Provider product page
Provider
Bioworld Technology, Inc
Product name
SLC6A12 polyclonal antibody
Antibody type
Polyclonal
Antigen
A synthetic peptide corresponding to residues in Human SLC6A12
Description
BGT-1, also known as sodium- and chloride-dependent betaine transporter, SLC6A12 (solute carrier family 6 member 12) or Na(+)/Cl(-) betaine/GABA transporter, is a 614 amino acid protein. As a multi-pass membrane protein, BGT-1 localizes to liver, heart, skeletal muscle and placenta and is widely distributed in brain. BGT-1 has the typical structure of neurotransmitter transporters, with twelve transmembrane domains and a large extracellular loop between the third and fourth transmembrane domains. BGT-1 transports betaine and GABA, and may have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation. BGT-1 is associated with mucus production in asthma, and could affect reversibility of lung function abnormalities in aspirin-intolerant asthma patients. BGT-1 displays significant functional differences from the other members of the GABA transporter family.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
SLC6A12 protein structure - BS60695 shown in red.