Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- BS60695 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- SLC6A12 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- A synthetic peptide corresponding to residues in Human SLC6A12
- Description
- BGT-1, also known as sodium- and chloride-dependent betaine transporter, SLC6A12 (solute carrier family 6 member 12) or Na(+)/Cl(-) betaine/GABA transporter, is a 614 amino acid protein. As a multi-pass membrane protein, BGT-1 localizes to liver, heart, skeletal muscle and placenta and is widely distributed in brain. BGT-1 has the typical structure of neurotransmitter transporters, with twelve transmembrane domains and a large extracellular loop between the third and fourth transmembrane domains. BGT-1 transports betaine and GABA, and may have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation. BGT-1 is associated with mucus production in asthma, and could affect reversibility of lung function abnormalities in aspirin-intolerant asthma patients. BGT-1 displays significant functional differences from the other members of the GABA transporter family.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- Western blot (WB) analysis of SLC6A12 pAb at 1:500 dilutionLane1:HEK293T whole cell lysateLane2:sp2/0 whole cell lysate Lane3:PC12 whole cell lysate