A010-70
antibody from Badrilla Ltd
Targeting: CACNA1C
CACH2, CACN2, CACNL1A1, Cav1.2, CCHL1A1, LQT8, TS
Antibody data
- Antibody Data
- Antigen structure
- References [2]
- Comments [0]
- Validations [0]
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- Product number
- A010-70 - Provider product page
- Provider
- Badrilla Ltd
- Product name
- Anti-Cav1.2 Phospho Serine-1928
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide
- Description
- The L-type Ca2+ channel (LTCC, or Cav1.2 or dihydropyridine receptor) is a voltage gated Ca2+ channel of the plasma membrane in brain and heart, which is responsible for the influx of Ca2+ to initiate neurotransmitter release (in neurones) or muscle contraction (in cardiac muscle). The channel is controlled by a number of chemical influences including phosphorylation on Ser-1928 by PKA which enhances ion channel activity. Ser-1928 from rabbit, is conserved across all mammalian species and is thought to be phosphorylated in response to elevated cAMP in these species.
- Host
- Rabbit
- Antigen sequence
LGRRAS(PO3H2)FHLE1932
- Isotype
- IgG
- Vial size
- 50 µl
- Storage
- Lyophilised: 4 °C Reconstituted:-80 °C
- Handling
- Reconstitute lyophilised powder in 50 µl of 18 MΩ H2O, aliquot and store frozen at -80 °C for 1 year. Avoid freeze - thaw cycles
Submitted references Adenylyl cyclase/cAMP-PKA-mediated phosphorylation of basal L-type Ca(2+) channels in mouse embryonic ventricular myocytes.
Inhibition of PKCα/β with ruboxistaurin antagonizes heart failure in pigs after myocardial infarction injury.
Yan X, Gao S, Tang M, Xi J, Gao L, Zhu M, Luo H, Hu X, Zheng Y, Hescheler J, Liang H
Cell calcium 2011 Nov;50(5):433-43
Cell calcium 2011 Nov;50(5):433-43
Inhibition of PKCα/β with ruboxistaurin antagonizes heart failure in pigs after myocardial infarction injury.
Ladage D, Tilemann L, Ishikawa K, Correll RN, Kawase Y, Houser SR, Molkentin JD, Hajjar RJ
Circulation research 2011 Dec 9;109(12):1396-400
Circulation research 2011 Dec 9;109(12):1396-400
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