BS2479

antibody from Bioworld Technology, Inc

Targeting: DGKQ DAGK, DAGK4, DAGK7

Western blot (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

BS2479

Provider

Bioworld Technology, Inc

Proper citation

Bioworld Technology Cat#BS2479, RRID:AB_1662777

Product name

DGK IJ (S725) polyclonal antibody

Antibody type

Polyclonal

Antigen

Synthetic peptide, corresponding to amino acids 700-750 of Human DGK-IJ.

Description

Diacylglycerol (DAG) is a fundamental lipid second messenger that is produced in the nucleus. The accumulation of DAG in the nucleus is important for the regulation of cell growth and differentiation. Diacylglycerol kinases (DGKs) convert DAG to phosphatidic acid, thereby terminating diacylglycerol signaling, which results in the reduction of protein kinase C activity and cell cycle progression of T lymphocytes. Diacylglycerol kinases are divided into five subtypes, Type I-Type V. DGK-IJ is a Type V DGK, and localizes mainly to the nucleus of various cell lines, such as MDA-MB-453, MCF-7, PC12 and HeLa. Nuclear DGK-IJ co-localizes with phosphatidylinositol 4,5-bisphosphate (PIP(2)). DGK-IJ is the isoform responsive to ϫ-Thrombin stimulation.

Reactivity

Human

Host

Rabbit

Isotype

IgG

Vial size

100ul

Concentration

1 mg/ml

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.