CABT-B9201

antibody from Creative Diagnostics

Targeting: DTNA D18S892E, DRP3, DTN, DTN-1, DTN-2, DTN-3

Western blot (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

CABT-B9201

Provider

Creative Diagnostics

Product name

Mouse anti-Mouse Dystrobrevin monoclonal antibody, clone 34

Antibody type

Monoclonal

Description

Acetylcholine receptor clustering is considered an early event and a marker for synaptogenesis between a motor neuron and a muscle fiber. This process is mediated by the extracellular protein Agrin which binds to Ï« and ÉÇ Dystroglycan, previously discovered as Dystrobrevin- associated proteins. Dystrobrevin binds to the actin cytoskeleton by its N-terminal domain, thus providing the link between the actin cytoskeleton and receptor clustering. In Torpedo electric organ, Dystrobrevin is a prominent phosphotyrosine-containing protein. Murine Dystrobrevins comprise a family of four related proteins (1-4) with similar function, generated by alternative splicing. Dystrobrevin-1 is 688 amino acids and has an apparent mobility of 87kDa. Dystrobrevin-2 shares almost identical sequence with Dystrobrevin-1 in the first 500 amino acids and has an apparent mobility of 59kDa.

Reactivity

Mouse, Rat, Rabbit

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

34

Vial size

50 _g

Concentration

250 Ã×g/ml

Storage

Store undiluted at -20°C.