13967-1-AP
antibody from Proteintech Group
Targeting: IFT88
D13S1056E, hTg737, MGC26259, Tg737, TTC10
Antibody data
- Antibody Data
- Antigen structure
- References [262]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
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- Product number
- 13967-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13967-1-AP, RRID:AB_2121979
- Product name
- IFT88 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated IFT88 antibody (Cat. #13967-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat, Canine and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat, Canine
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Essential Role of CFAP53 in Sperm Flagellum Biogenesis.
Analyzing Centrioles and Cilia by Expansion Microscopy.
The type 3 adenylyl cyclase is crucial for intestinal mucosal neural network in the gut lamina propria.
Odontoblast differentiation is regulated by an interplay between primary cilia and the canonical Wnt pathway.
Cilium induction triggers differentiation of glioma stem cells.
A ciliopathy complex builds distal appendages to initiate ciliogenesis.
ARL3 and ARL13B GTPases participate in distinct steps of INPP5E targeting to the ciliary membrane.
FBW7 couples structural integrity with functional output of primary cilia.
Decreased IFT88 expression with primary cilia shortening causes mitochondrial dysfunction in cisplatin-induced tubular injury.
IFT88 deficiency in proximal tubular cells exaggerates cisplatin-induced injury by suppressing autophagy.
Primary Ciliogenesis by 2-Isopropylmalic Acid Prevents PM2.5-Induced Inflammatory Response and MMP-1 Activation in Human Dermal Fibroblasts and a 3-D-Skin Model.
Macroautophagy supports Sonic Hedgehog signaling by promoting Patched1 degradation.
Time-resolved proteomics profiling of the ciliary Hedgehog response.
Melanocortin 4 receptor signals at the neuronal primary cilium to control food intake and body weight.
Divergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptoms.
ARP-T1-associated Bazex-Dupré-Christol syndrome is an inherited basal cell cancer with ciliary defects characteristic of ciliopathies.
Primary cilia-dependent lipid raft/caveolin dynamics regulate adipogenesis.
Photoreceptor cilia, in contrast to primary cilia, grant entry to a partially assembled BBSome.
Investigating Primary Cilia during Peripheral Nervous System Formation.
Ciliary neuropeptidergic signaling dynamically regulates excitatory synapses in postnatal neocortical pyramidal neurons.
Ciliopathy protein HYLS1 coordinates the biogenesis and signaling of primary cilia by activating the ciliary lipid kinase PIPKIγ.
Increase in primary cilia in the epidermis of patients with atopic dermatitis and psoriasis.
Genotoxic stress-activated DNA-PK-p53 cascade and autophagy cooperatively induce ciliogenesis to maintain the DNA damage response.
BAG3 is a negative regulator of ciliogenesis in glioblastoma and triple-negative breast cancer cells.
The highly conserved FOXJ1 target CFAP161 is dispensable for motile ciliary function in mouse and Xenopus.
Rab34 GTPase mediates ciliary membrane formation in the intracellular ciliogenesis pathway.
Defective INPP5E distribution in NPHP1-related Senior-Loken syndrome.
Nonredundant roles of DIAPHs in primary ciliogenesis.
Interaction of INPP5E with ARL13B is essential for its ciliary membrane retention but dispensable for its ciliary entry.
Cooperation of the IFT-A complex with the IFT-B complex is required for ciliary retrograde protein trafficking and GPCR import.
Phosphosite T674A mutation in kinesin family member 3A fails to reproduce tissue and ciliary defects characteristic of CILK1 loss of function.
RAB19 Directs Cortical Remodeling and Membrane Growth for Primary Ciliogenesis.
Aurora Kinase A proximity map reveals centriolar satellites as regulators of its ciliary function.
Differential Roles of Tubby Family Proteins in Ciliary Formation and Trafficking.
Septin 7 is a centrosomal protein that ensures S phase entry and microtubule nucleation by maintaining the abundance of p150glued.
The autophagy protein ATG16L1 cooperates with IFT20 and INPP5E to regulate the turnover of phosphoinositides at the primary cilium.
FOP Negatively Regulates Ciliogenesis and Promotes Cell Cycle Re-entry by Facilitating Primary Cilia Disassembly.
Moderate Fluid Shear Stress Regulates Heme Oxygenase-1 Expression to Promote Autophagy and ECM Homeostasis in the Nucleus Pulposus Cells.
The primary cilium and lipophagy translate mechanical forces to direct metabolic adaptation of kidney epithelial cells.
Carbon black nanoparticles induce HDAC6-mediated inflammatory responses in 16HBE cells.
Use of patient derived urine renal epithelial cells to confirm pathogenicity of PKHD1 alleles.
O-GlcNAc transferase regulates centriole behavior and intraflagellar transport to promote ciliogenesis.
Differentiation of ciliated human midbrain-derived LUHMES neurons.
Mutations in GRK2 cause Jeune syndrome by impairing Hedgehog and canonical Wnt signaling.
Primary cilia mediate early life programming of adiposity through lysosomal regulation in the developing mouse hypothalamus.
Primary cilium remodeling mediates a cell signaling switch in differentiating neurons.
Genetic interaction of mammalian IFT-A paralogs regulates cilia disassembly, ciliary entry of membrane protein, Hedgehog signaling, and embryogenesis.
ASK1-Mediated Phosphorylation Blocks HDAC6 Ubiquitination and Degradation to Drive the Disassembly of Photoreceptor Connecting Cilia.
SIRT2 Affects Primary Cilia Formation by Regulating mTOR Signaling in Retinal Pigmented Epithelial Cells.
Biallelic Mutations in Tetratricopeptide Repeat Domain 26 (Intraflagellar Transport 56) Cause Severe Biliary Ciliopathy in Humans.
A novel homozygous mutation in WDR19 induces disorganization of microtubules in sperm flagella and nonsyndromic asthenoteratospermia.
Acute inhibition of centriolar satellite function and positioning reveals their functions at the primary cilium.
IFT proteins interact with HSET to promote supernumerary centrosome clustering in mitosis.
Homozygous mutations in DZIP1 can induce asthenoteratospermia with severe MMAF.
Ciliary proteins specify the cell inflammatory response by tuning NFκB signalling, independently of primary cilia.
Ciliogenesis and Hedgehog signalling are suppressed downstream of KRAS during acinar-ductal metaplasia in mouse.
Requirement of NPHP5 in the hierarchical assembly of basal feet associated with basal bodies of primary cilia.
The association of microcephaly protein WDR62 with CPAP/IFT88 is required for cilia formation and neocortical development.
PI3KC2α-dependent and VPS34-independent generation of PI3P controls primary cilium-mediated autophagy in response to shear stress.
Aldosterone controls primary cilium length and cell size in renal collecting duct principal cells.
NRF2 negatively regulates primary ciliogenesis and hedgehog signaling.
Altered gene regulation as a candidate mechanism by which ciliopathy gene SDCCAG8 contributes to schizophrenia and cognitive function.
DIAPH1 regulates ciliogenesis and trafficking in primary cilia.
Low fluid shear stress promoted ciliogenesis via Dvl2 in hUVECs.
Exploratory neuroimmune profiling identifies CNS-specific alterations in COVID-19 patients with neurological involvement.
The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis.
Primary Cilia Mediate Wnt5a/β-catenin Signaling to Regulate Adipogenic Differentiation of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Following Calcium Induction.
Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration.
Primary cilia control glucose homeostasis via islet paracrine interactions.
The primary cilium dampens proliferative signaling and represses a G2/M transcriptional network in quiescent myoblasts.
Primary Cilia Blockage Promotes the Malignant Behaviors of Hepatocellular Carcinoma via Induction of Autophagy.
661W Photoreceptor Cell Line as a Cell Model for Studying Retinal Ciliopathies.
NRF2-dependent gene expression promotes ciliogenesis and Hedgehog signaling.
Requirement of IFT-B-BBSome complex interaction in export of GPR161 from cilia.
A Smo/Gli Multitarget Hedgehog Pathway Inhibitor Impairs Tumor Growth.
Phosphorylation of CEP83 by TTBK2 is necessary for cilia initiation.
Nucleus pulposus primary cilia alter their length in response to changes in extracellular osmolarity but do not control TonEBP-mediated osmoregulation.
Fetuin-A Inhibits Placental Cell Growth and Ciliogenesis in Gestational Diabetes Mellitus.
Ciliogenesis-coupled accumulation of IFT-B proteins in a novel cytoplasmic compartment.
C11ORF74 interacts with the IFT-A complex and participates in ciliary BBSome localization.
Centriolar satellites are required for efficient ciliogenesis and ciliary content regulation.
Extraciliary roles of the ciliopathy protein JBTS17 in mitosis and neurogenesis.
Chloroquine inhibits human retina pigmented epithelial cell growth and microtubule nucleation by downregulating p150glued.
IFT88 controls NuMA enrichment at k-fibers minus-ends to facilitate their re-anchoring into mitotic spindles.
Type I collagen-induced YAP nuclear expression promotes primary cilia growth and contributes to cell migration in confluent mouse embryo fibroblast 3T3-L1 cells.
Malformations in the Murine Kidney Caused by Loss of CENP-F Function.
Atoh1 Controls Primary Cilia Formation to Allow for SHH-Triggered Granule Neuron Progenitor Proliferation.
Expansion microscopy for the analysis of centrioles and cilia.
Primary cilia mediate mitochondrial stress responses to promote dopamine neuron survival in a Parkinson's disease model.
Glucose homeostasis is regulated by pancreatic β-cell cilia via endosomal EphA-processing.
Cilia function is associated with axon initial segment morphology.
A CEP104-CSPP1 Complex Is Required for Formation of Primary Cilia Competent in Hedgehog Signaling.
Failure to reabsorb the primary cilium induces cellular senescence.
Bi-allelic Mutations in FAM149B1 Cause Abnormal Primary Cilium and a Range of Ciliopathy Phenotypes in Humans.
Cellular ciliary phenotyping indicates pathogenicity of novel variants in IFT140 and confirms a Mainzer-Saldino syndrome diagnosis.
A distal centriolar protein network controls organelle maturation and asymmetry.
Characterization of Primary Cilia in Normal Fallopian Tube Epithelium and Serous Tubal Intraepithelial Carcinoma.
Dynein-2 intermediate chains play crucial but distinct roles in primary cilia formation and function.
Primary cilia sensitize endothelial cells to BMP and prevent excessive vascular regression.
The Joubert syndrome protein ARL13B binds tubulin to maintain uniform distribution of proteins along the ciliary membrane.
Patient-iPSC-Derived Kidney Organoids Show Functional Validation of a Ciliopathic Renal Phenotype and Reveal Underlying Pathogenetic Mechanisms.
Cell type-specific regulation of ciliary transition zone assembly in vertebrates.
Inhibition of Hedgehog signaling suppresses proliferation and microcyst formation of human Autosomal Dominant Polycystic Kidney Disease cells.
Primary Cilia Mediate Diverse Kinase Inhibitor Resistance Mechanisms in Cancer.
TSC1 and TSC2 regulate cilia length and canonical Hedgehog signaling via different mechanisms.
IFT88 mutations identified in individuals with non-syndromic recessive retinal degeneration result in abnormal ciliogenesis.
Super-Resolution Imaging Reveals TCTN2 Depletion-Induced IFT88 Lumen Leakage and Ciliary Weakening.
Interaction of WDR60 intermediate chain with TCTEX1D2 light chain of the dynein-2 complex is crucial for ciliary protein trafficking.
Drug-induced ciliogenesis in pancreatic cancer cells is facilitated by the secreted ATP-purinergic receptor signaling pathway.
Glucose deprivation induces primary cilium formation through mTORC1 inactivation.
CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function.
The small GTPase RSG1 controls a final step in primary cilia initiation.
IFT20 modulates ciliary PDGFRα signaling by regulating the stability of Cbl E3 ubiquitin ligases.
Cilia loss sensitizes cells to transformation by activating the mevalonate pathway.
Constitutively-active FGFR3 disrupts primary cilium length and IFT20 trafficking in various chondrocyte models of achondroplasia.
Export of membrane proteins from the Golgi complex to the primary cilium requires the kinesin motor, KIFC1.
DNAAF1 links heart laterality with the AAA+ ATPase RUVBL1 and ciliary intraflagellar transport.
Ciliopathy-associated mutations of IFT122 impair ciliary protein trafficking but not ciliogenesis.
Spinocerebellar ataxia type 11-associated alleles of Ttbk2 dominantly interfere with ciliogenesis and cilium stability.
Kinesin-2 and IFT-A act as a complex promoting nuclear localization of β-catenin during Wnt signalling.
Microtubule asters anchored by FSD1 control axoneme assembly and ciliogenesis.
Loss-of-function of IFT88 determines metabolic phenotypes in thyroid cancer.
Interaction of heterotrimeric kinesin-II with IFT-B-connecting tetramer is crucial for ciliogenesis.
CFAP70 Is a Novel Axoneme-Binding Protein That Localizes at the Base of the Outer Dynein Arm and Regulates Ciliary Motility.
FGFR1-mediated protocadherin-15 loading mediates cargo specificity during intraflagellar transport in inner ear hair-cell kinocilia.
Cilia-localized LKB1 regulates chemokine signaling, macrophage recruitment, and tissue homeostasis in the kidney.
Basal exon skipping and nonsense-associated altered splicing allows bypassing complete CEP290 loss-of-function in individuals with unusually mild retinal disease.
Robust interaction of IFT70 with IFT52-IFT88 in the IFT-B complex is required for ciliogenesis.
Centrobin controls primary ciliogenesis in vertebrates.
Fixation methods can differentially affect ciliary protein immunolabeling.
iTRAQ-Based Proteomic Analysis of Neonatal Kidney from Offspring of Protein Restricted Rats Reveals Abnormalities in Intraflagellar Transport Proteins.
The Meckel syndrome- associated protein MKS1 functionally interacts with components of the BBSome and IFT complexes to mediate ciliary trafficking and hedgehog signaling.
Missense mutations in the WD40 domain of AHI1 cause non-syndromic retinitis pigmentosa.
The ciliary membrane-associated proteome reveals actin-binding proteins as key components of cilia.
Serotonin 5-HT6 receptors affect cognition in a mouse model of Alzheimer's disease by regulating cilia function.
BBSome function is required for both the morphogenesis and maintenance of the photoreceptor outer segment.
Inter-dependent apical microtubule and actin dynamics orchestrate centrosome retention and neuronal delamination.
Microtubule stabilization drives 3D centrosome migration to initiate primary ciliogenesis.
USP9X counteracts differential ubiquitination of NPHP5 by MARCH7 and BBS11 to regulate ciliogenesis.
Identification of Elongated Primary Cilia with Impaired Mechanotransduction in Idiopathic Scoliosis Patients.
Ciliary entry of KIF17 is dependent on its binding to the IFT-B complex via IFT46-IFT56 as well as on its nuclear localization signal.
Primary Cilium-Regulated EG-VEGF Signaling Facilitates Trophoblast Invasion.
Mutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease.
NEK7 is required for G1 progression and procentriole formation.
DGKδ triggers endoplasmic reticulum release of IFT88-containing vesicles destined for the assembly of primary cilia.
In Vitro Modeling Using Ciliopathy-Patient-Derived Cells Reveals Distinct Cilia Dysfunctions Caused by CEP290 Mutations.
The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base.
Primary cilia control the maturation of tubular lumen in renal collecting duct epithelium.
KIF13B establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling.
Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision.
HDAC2 promotes loss of primary cilia in pancreatic ductal adenocarcinoma.
Regulation of ciliary retrograde protein trafficking by the Joubert syndrome proteins ARL13B and INPP5E.
IFT proteins spatially control the geometry of cleavage furrow ingression and lumen positioning.
mTORC1-Mediated Inhibition of 4EBP1 Is Essential for Hedgehog Signaling-Driven Translation and Medulloblastoma.
A mutation in IFT43 causes non-syndromic recessive retinal degeneration.
A human patient-derived cellular model of Joubert syndrome reveals ciliary defects which can be rescued with targeted therapies.
A novel role for primary cilia in airway remodeling.
KDM3A coordinates actin dynamics with intraflagellar transport to regulate cilia stability.
IFT56 regulates vertebrate developmental patterning by maintaining IFTB complex integrity and ciliary microtubule architecture.
Practical method for targeted disruption of cilia-related genes by using CRISPR/Cas9-mediated, homology-independent knock-in system.
STED and STORM Superresolution Imaging of Primary Cilia.
Immunofluorescent staining of septins in primary cilia.
Destabilization of the IFT-B cilia core complex due to mutations in IFT81 causes a Spectrum of Short-Rib Polydactyly Syndrome.
A Conserved Role for Girdin in Basal Body Positioning and Ciliogenesis.
Zfp423 Regulates Sonic Hedgehog Signaling via Primary Cilium Function.
The serologically defined colon cancer antigen-3 (SDCCAG3) is involved in the regulation of ciliogenesis.
Defective ciliogenesis in thyroid hürthle cell tumors is associated with increased autophagy.
Role for the IFT-A Complex in Selective Transport to the Primary Cilium.
Tethering of an E3 ligase by PCM1 regulates the abundance of centrosomal KIAA0586/Talpid3 and promotes ciliogenesis.
Tumor Suppressor Folliculin Regulates mTORC1 through Primary Cilia.
Overall Architecture of the Intraflagellar Transport (IFT)-B Complex Containing Cluap1/IFT38 as an Essential Component of the IFT-B Peripheral Subcomplex.
Identification of drugs that restore primary cilium expression in cancer cells.
Genome-wide screen identifies novel machineries required for both ciliogenesis and cell cycle arrest upon serum starvation.
MicroRNA-548a-5p promotes proliferation and inhibits apoptosis in hepatocellular carcinoma cells by targeting Tg737.
The Interaction of Myc with Miz1 Defines Medulloblastoma Subgroup Identity.
Biological and Chemical Removal of Primary Cilia Affects Mechanical Activation of Chondrogenesis Markers in Chondroprogenitors and Hypertrophic Chondrocytes.
Phosphatidylinositol phosphate kinase PIPKIγ and phosphatase INPP5E coordinate initiation of ciliogenesis.
Novel role for the midbody in primary ciliogenesis by polarized epithelial cells.
Mutations in human C2CD3 cause skeletal dysplasia and provide new insights into phenotypic and cellular consequences of altered C2CD3 function.
Tctex1d2 associates with short-rib polydactyly syndrome proteins and is required for ciliogenesis.
Chibby functions to preserve normal ciliary morphology through the regulation of intraflagellar transport in airway ciliated cells.
Imaging centrosomes and cilia in the mouse kidney.
Characterization of tetratricopeptide repeat-containing proteins critical for cilia formation and function.
A Cilia Independent Role of Ift88/Polaris during Cell Migration.
Identification of a novel MKS locus defined by TMEM107 mutation.
Superresolution Pattern Recognition Reveals the Architectural Map of the Ciliary Transition Zone.
Proteomics of Primary Cilia by Proximity Labeling.
Myosin heavy chain 10 (MYH10) is required for centriole migration during the biogenesis of primary cilia.
BIX-01294-induced autophagy regulates elongation of primary cilia.
The kinetochore protein, CENPF, is mutated in human ciliopathy and microcephaly phenotypes.
Centrin2 regulates CP110 removal in primary cilium formation.
A founder CEP120 mutation in Jeune asphyxiating thoracic dystrophy expands the role of centriolar proteins in skeletal ciliopathies.
Adipogenic Differentiation of hMSCs is Mediated by Recruitment of IGF-1r Onto the Primary Cilium Associated With Cilia Elongation.
TCTEX1D2 mutations underlie Jeune asphyxiating thoracic dystrophy with impaired retrograde intraflagellar transport.
Cell biology. Reversible centriole depletion with an inhibitor of Polo-like kinase 4.
Mutations in DYNC2LI1 disrupt cilia function and cause short rib polydactyly syndrome.
The MAL protein is crucial for proper membrane condensation at the ciliary base, which is required for primary cilium elongation.
Leptin Elongates Hypothalamic Neuronal Cilia via Transcriptional Regulation and Actin Destabilization.
Specific variants in WDR35 cause a distinctive form of Ellis-van Creveld syndrome by disrupting the recruitment of the EvC complex and SMO into the cilium.
DYNC2LI1 mutations broaden the clinical spectrum of dynein-2 defects.
DCDC2 mutations cause a renal-hepatic ciliopathy by disrupting Wnt signaling.
Lineage specificity of primary cilia in the mouse embryo.
Deacetylation of α-tubulin and cortactin is required for HDAC6 to trigger ciliary disassembly.
Nek2 activation of Kif24 ensures cilium disassembly during the cell cycle.
GSK3β-Dzip1-Rab8 cascade regulates ciliogenesis after mitosis.
An in vivo chemical genetic screen identifies phosphodiesterase 4 as a pharmacological target for hedgehog signaling inhibition.
Reciprocal regulation of cilia and autophagy via the MTOR and proteasome pathways.
Nephrocystin proteins NPHP5 and Cep290 regulate BBSome integrity, ciliary trafficking and cargo delivery.
Ciliary abnormalities in senescent human fibroblasts impair proliferative capacity.
Primary cilia signaling mediates intraocular pressure sensation.
Nedd9 restrains renal cystogenesis in Pkd1-/- mice.
Basal foot MTOC organizes pillar MTs required for coordination of beating cilia.
Crystal structures of IFT70/52 and IFT52/46 provide insight into intraflagellar transport B core complex assembly.
Disruption of the retinitis pigmentosa 28 gene Fam161a in mice affects photoreceptor ciliary structure and leads to progressive retinal degeneration.
CYLD mediates ciliogenesis in multiple organs by deubiquitinating Cep70 and inactivating HDAC6.
The intraflagellar transport protein IFT27 promotes BBSome exit from cilia through the GTPase ARL6/BBS3.
Detection of primary cilia in human glioblastoma.
Primary cilia control hedgehog signaling during muscle differentiation and are deregulated in rhabdomyosarcoma.
ICK is essential for cell type-specific ciliogenesis and the regulation of ciliary transport.
The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment.
Deletion of airway cilia results in noninflammatory bronchiectasis and hyperreactive airways.
Apical abscission alters cell polarity and dismantles the primary cilium during neurogenesis.
Mutations in PLK4, encoding a master regulator of centriole biogenesis, cause microcephaly, growth failure and retinopathy.
Katanin p80 regulates human cortical development by limiting centriole and cilia number.
Active transport and diffusion barriers restrict Joubert Syndrome-associated ARL13B/ARL-13 to an Inv-like ciliary membrane subdomain.
Acute versus chronic loss of mammalian Azi1/Cep131 results in distinct ciliary phenotypes.
Calcium-binding capacity of centrin2 is required for linear POC5 assembly but not for nucleotide excision repair.
Transition fibre protein FBF1 is required for the ciliary entry of assembled intraflagellar transport complexes.
Short-rib polydactyly and Jeune syndromes are caused by mutations in WDR60.
Subretinal gene therapy of mice with Bardet-Biedl syndrome type 1.
ERK-mediated suppression of cilia in cisplatin-induced tubular cell apoptosis and acute kidney injury.
Functional interaction between autophagy and ciliogenesis.
Genetically encoded calcium indicator illuminates calcium dynamics in primary cilia.
Mutations in the gene encoding IFT dynein complex component WDR34 cause Jeune asphyxiating thoracic dystrophy.
Exome sequencing identifies DYNC2H1 mutations as a common cause of asphyxiating thoracic dystrophy (Jeune syndrome) without major polydactyly, renal or retinal involvement.
Visualizing renal primary cilia.
Rer1p maintains ciliary length and signaling by regulating γ-secretase activity and Foxj1a levels.
CEP162 is an axoneme-recognition protein promoting ciliary transition zone assembly at the cilia base.
Pathogenic NPHP5 mutations impair protein interaction with Cep290, a prerequisite for ciliogenesis.
Superresolution STED microscopy reveals differential localization in primary cilia.
The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling.
Centriole distal appendages promote membrane docking, leading to cilia initiation.
Kif3a interacts with Dynactin subunit p150 Glued to organize centriole subdistal appendages.
CCRK depletion inhibits glioblastoma cell proliferation in a cilium-dependent manner.
CCDC41 is required for ciliary vesicle docking to the mother centriole.
HDAC6 inhibition restores ciliary expression and decreases tumor growth.
The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis.
BBS proteins interact genetically with the IFT pathway to influence SHH-related phenotypes.
Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein.
The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking.
A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened.
Complex interactions between genes controlling trafficking in primary cilia.
A role for the primary cilium in Notch signaling and epidermal differentiation during skin development.
Centriolar kinesin Kif24 interacts with CP110 to remodel microtubules and regulate ciliogenesis.
A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition.
Disruption of a ciliary B9 protein complex causes Meckel syndrome.
The role of RPGR in cilia formation and actin stability.
Functional characterization of putative cilia genes by high-content analysis.
The cilia protein IFT88 is required for spindle orientation in mitosis.
TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia.
Primary cilia regulate mTORC1 activity and cell size through Lkb1.
DISC1 regulates primary cilia that display specific dopamine receptors.
Wu B, Yu X, Liu C, Wang L, Huang T, Lu G, Chen ZJ, Li W, Liu H
Frontiers in cell and developmental biology 2021;9:676910
Frontiers in cell and developmental biology 2021;9:676910
Analyzing Centrioles and Cilia by Expansion Microscopy.
Kong D, Loncarek J
Methods in molecular biology (Clifton, N.J.) 2021;2329:249-263
Methods in molecular biology (Clifton, N.J.) 2021;2329:249-263
The type 3 adenylyl cyclase is crucial for intestinal mucosal neural network in the gut lamina propria.
Zhou K, Zhou Y, Yang D, Chen T, Liu X, Li S, Wang Z
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 2021 Sep;33(9):e14140
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 2021 Sep;33(9):e14140
Odontoblast differentiation is regulated by an interplay between primary cilia and the canonical Wnt pathway.
Kawata K, Narita K, Washio A, Kitamura C, Nishihara T, Kubota S, Takeda S
Bone 2021 Sep;150:116001
Bone 2021 Sep;150:116001
Cilium induction triggers differentiation of glioma stem cells.
Goranci-Buzhala G, Mariappan A, Ricci-Vitiani L, Josipovic N, Pacioni S, Gottardo M, Ptok J, Schaal H, Callaini G, Rajalingam K, Dynlacht B, Hadian K, Papantonis A, Pallini R, Gopalakrishnan J
Cell reports 2021 Sep 7;36(10):109656
Cell reports 2021 Sep 7;36(10):109656
A ciliopathy complex builds distal appendages to initiate ciliogenesis.
Kumar D, Rains A, Herranz-Pérez V, Lu Q, Shi X, Swaney DL, Stevenson E, Krogan NJ, Huang B, Westlake C, Garcia-Verdugo JM, Yoder BK, Reiter JF
The Journal of cell biology 2021 Sep 6;220(9)
The Journal of cell biology 2021 Sep 6;220(9)
ARL3 and ARL13B GTPases participate in distinct steps of INPP5E targeting to the ciliary membrane.
Fujisawa S, Qiu H, Nozaki S, Chiba S, Katoh Y, Nakayama K
Biology open 2021 Sep 15;10(9)
Biology open 2021 Sep 15;10(9)
FBW7 couples structural integrity with functional output of primary cilia.
Petsouki E, Gerakopoulos V, Szeto N, Chang W, Humphrey MB, Tsiokas L
Communications biology 2021 Sep 13;4(1):1066
Communications biology 2021 Sep 13;4(1):1066
Decreased IFT88 expression with primary cilia shortening causes mitochondrial dysfunction in cisplatin-induced tubular injury.
Fujii R, Hasegawa S, Maekawa H, Inoue T, Yoshioka K, Uni R, Ikeda Y, Nangaku M, Inagi R
American journal of physiology. Renal physiology 2021 Sep 1;321(3):F278-F292
American journal of physiology. Renal physiology 2021 Sep 1;321(3):F278-F292
IFT88 deficiency in proximal tubular cells exaggerates cisplatin-induced injury by suppressing autophagy.
Wang S, Zhuang S, Dong Z
American journal of physiology. Renal physiology 2021 Sep 1;321(3):F269-F277
American journal of physiology. Renal physiology 2021 Sep 1;321(3):F269-F277
Primary Ciliogenesis by 2-Isopropylmalic Acid Prevents PM2.5-Induced Inflammatory Response and MMP-1 Activation in Human Dermal Fibroblasts and a 3-D-Skin Model.
Bae JE, Min D, Choi JY, Choi H, Kim JB, Park NY, Jo DS, Kim YH, Na HW, Kim YJ, Kim ES, Kim HJ, Cho DH
International journal of molecular sciences 2021 Oct 10;22(20)
International journal of molecular sciences 2021 Oct 10;22(20)
Macroautophagy supports Sonic Hedgehog signaling by promoting Patched1 degradation.
Yang X, Jin N, Wang Y, Yao Y, Wang Y, Li T, Liu C, Yu T, Yin H, Zhang Z, Cheng SY, Yue S
Biochimica et biophysica acta. Molecular cell research 2021 Nov;1868(12):119124
Biochimica et biophysica acta. Molecular cell research 2021 Nov;1868(12):119124
Time-resolved proteomics profiling of the ciliary Hedgehog response.
May EA, Kalocsay M, D'Auriac IG, Schuster PS, Gygi SP, Nachury MV, Mick DU
The Journal of cell biology 2021 May 3;220(5)
The Journal of cell biology 2021 May 3;220(5)
Melanocortin 4 receptor signals at the neuronal primary cilium to control food intake and body weight.
Wang Y, Bernard A, Comblain F, Yue X, Paillart C, Zhang S, Reiter JF, Vaisse C
The Journal of clinical investigation 2021 May 3;131(9)
The Journal of clinical investigation 2021 May 3;131(9)
Divergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptoms.
Song E, Bartley CM, Chow RD, Ngo TT, Jiang R, Zamecnik CR, Dandekar R, Loudermilk RP, Dai Y, Liu F, Sunshine S, Liu J, Wu W, Hawes IA, Alvarenga BD, Huynh T, McAlpine L, Rahman NT, Geng B, Chiarella J, Goldman-Israelow B, Vogels CBF, Grubaugh ND, Casanovas-Massana A, Phinney BS, Salemi M, Alexander JR, Gallego JA, Lencz T, Walsh H, Wapniarski AE, Mohanty S, Lucas C, Klein J, Mao T, Oh J, Ring A, Spudich S, Ko AI, Kleinstein SH, Pak J, DeRisi JL, Iwasaki A, Pleasure SJ, Wilson MR, Farhadian SF
Cell reports. Medicine 2021 May 18;2(5):100288
Cell reports. Medicine 2021 May 18;2(5):100288
ARP-T1-associated Bazex-Dupré-Christol syndrome is an inherited basal cell cancer with ciliary defects characteristic of ciliopathies.
Park HS, Papanastasi E, Blanchard G, Chiticariu E, Bachmann D, Plomann M, Morice-Picard F, Vabres P, Smahi A, Huber M, Pich C, Hohl D
Communications biology 2021 May 10;4(1):544
Communications biology 2021 May 10;4(1):544
Primary cilia-dependent lipid raft/caveolin dynamics regulate adipogenesis.
Yamakawa D, Katoh D, Kasahara K, Shiromizu T, Matsuyama M, Matsuda C, Maeno Y, Watanabe M, Nishimura Y, Inagaki M
Cell reports 2021 Mar 9;34(10):108817
Cell reports 2021 Mar 9;34(10):108817
Photoreceptor cilia, in contrast to primary cilia, grant entry to a partially assembled BBSome.
Hsu Y, Seo S, Sheffield VC
Human molecular genetics 2021 Mar 25;30(1):87-102
Human molecular genetics 2021 Mar 25;30(1):87-102
Investigating Primary Cilia during Peripheral Nervous System Formation.
Yusifov E, Dumoulin A, Stoeckli ET
International journal of molecular sciences 2021 Mar 20;22(6)
International journal of molecular sciences 2021 Mar 20;22(6)
Ciliary neuropeptidergic signaling dynamically regulates excitatory synapses in postnatal neocortical pyramidal neurons.
Tereshko L, Gao Y, Cary BA, Turrigiano GG, Sengupta P
eLife 2021 Mar 2;10
eLife 2021 Mar 2;10
Ciliopathy protein HYLS1 coordinates the biogenesis and signaling of primary cilia by activating the ciliary lipid kinase PIPKIγ.
Chen C, Xu Q, Zhang Y, Davies BA, Huang Y, Katzmann DJ, Harris PC, Hu J, Ling K
Science advances 2021 Jun;7(26)
Science advances 2021 Jun;7(26)
Increase in primary cilia in the epidermis of patients with atopic dermatitis and psoriasis.
Rizaldy D, Toriyama M, Kato H, Fukui R, Fujita F, Nakamura M, Okada F, Morita A, Ishii KJ
Experimental dermatology 2021 Jun;30(6):792-803
Experimental dermatology 2021 Jun;30(6):792-803
Genotoxic stress-activated DNA-PK-p53 cascade and autophagy cooperatively induce ciliogenesis to maintain the DNA damage response.
Chen TY, Huang BM, Tang TK, Chao YY, Xiao XY, Lee PR, Yang LY, Wang CY
Cell death and differentiation 2021 Jun;28(6):1865-1879
Cell death and differentiation 2021 Jun;28(6):1865-1879
BAG3 is a negative regulator of ciliogenesis in glioblastoma and triple-negative breast cancer cells.
Linder B, Klein C, Hoffmann ME, Bonn F, Dikic I, Kögel D
Journal of cellular biochemistry 2021 Jun 27;
Journal of cellular biochemistry 2021 Jun 27;
The highly conserved FOXJ1 target CFAP161 is dispensable for motile ciliary function in mouse and Xenopus.
Beckers A, Fuhl F, Ott T, Boldt K, Brislinger MM, Walentek P, Schuster-Gossler K, Hegermann J, Alten L, Kremmer E, Przykopanski A, Serth K, Ueffing M, Blum M, Gossler A
Scientific reports 2021 Jun 25;11(1):13333
Scientific reports 2021 Jun 25;11(1):13333
Rab34 GTPase mediates ciliary membrane formation in the intracellular ciliogenesis pathway.
Ganga AK, Kennedy MC, Oguchi ME, Gray S, Oliver KE, Knight TA, De La Cruz EM, Homma Y, Fukuda M, Breslow DK
Current biology : CB 2021 Jul 12;31(13):2895-2905.e7
Current biology : CB 2021 Jul 12;31(13):2895-2905.e7
Defective INPP5E distribution in NPHP1-related Senior-Loken syndrome.
Ning K, Song E, Sendayen BE, Prosseda PP, Chang KC, Ghaffarieh A, Alvarado JA, Wang B, Haider KM, Berbari NF, Hu Y, Sun Y
Molecular genetics & genomic medicine 2021 Jan;9(1):e1566
Molecular genetics & genomic medicine 2021 Jan;9(1):e1566
Nonredundant roles of DIAPHs in primary ciliogenesis.
Palander O, Lam A, Collins RF, Moraes TJ, Trimble WS
The Journal of biological chemistry 2021 Jan-Jun;296:100680
The Journal of biological chemistry 2021 Jan-Jun;296:100680
Interaction of INPP5E with ARL13B is essential for its ciliary membrane retention but dispensable for its ciliary entry.
Qiu H, Fujisawa S, Nozaki S, Katoh Y, Nakayama K
Biology open 2021 Jan 25;10(1)
Biology open 2021 Jan 25;10(1)
Cooperation of the IFT-A complex with the IFT-B complex is required for ciliary retrograde protein trafficking and GPCR import.
Kobayashi T, Ishida Y, Hirano T, Katoh Y, Nakayama K
Molecular biology of the cell 2021 Jan 1;32(1):45-56
Molecular biology of the cell 2021 Jan 1;32(1):45-56
Phosphosite T674A mutation in kinesin family member 3A fails to reproduce tissue and ciliary defects characteristic of CILK1 loss of function.
Gailey CD, Wang EJ, Jin L, Ahmadi S, Brautigan DL, Li X, Xu W, Scott MM, Fu Z
Developmental dynamics : an official publication of the American Association of Anatomists 2021 Feb;250(2):263-273
Developmental dynamics : an official publication of the American Association of Anatomists 2021 Feb;250(2):263-273
RAB19 Directs Cortical Remodeling and Membrane Growth for Primary Ciliogenesis.
Jewett CE, Soh AWJ, Lin CH, Lu Q, Lencer E, Westlake CJ, Pearson CG, Prekeris R
Developmental cell 2021 Feb 8;56(3):325-340.e8
Developmental cell 2021 Feb 8;56(3):325-340.e8
Aurora Kinase A proximity map reveals centriolar satellites as regulators of its ciliary function.
Arslanhan MD, Rauniyar N, Yates JR 3rd, Firat-Karalar EN
EMBO reports 2021 Aug 4;22(8):e51902
EMBO reports 2021 Aug 4;22(8):e51902
Differential Roles of Tubby Family Proteins in Ciliary Formation and Trafficking.
Hong JJ, Kim KE, Park SY, Bok J, Seo JT, Moon SJ
Molecules and cells 2021 Aug 31;44(8):591-601
Molecules and cells 2021 Aug 31;44(8):591-601
Septin 7 is a centrosomal protein that ensures S phase entry and microtubule nucleation by maintaining the abundance of p150glued.
Chen TY, Lin TC, Kuo PL, Chen ZR, Cheng HL, Chao YY, Syu JS, Lu FI, Wang CY
Journal of cellular physiology 2021 Apr;236(4):2706-2724
Journal of cellular physiology 2021 Apr;236(4):2706-2724
The autophagy protein ATG16L1 cooperates with IFT20 and INPP5E to regulate the turnover of phosphoinositides at the primary cilium.
Boukhalfa A, Roccio F, Dupont N, Codogno P, Morel E
Cell reports 2021 Apr 27;35(4):109045
Cell reports 2021 Apr 27;35(4):109045
FOP Negatively Regulates Ciliogenesis and Promotes Cell Cycle Re-entry by Facilitating Primary Cilia Disassembly.
Jiang H, Liu S, Cheung MH, Amin A, Liang C
Frontiers in cell and developmental biology 2020;8:590449
Frontiers in cell and developmental biology 2020;8:590449
Moderate Fluid Shear Stress Regulates Heme Oxygenase-1 Expression to Promote Autophagy and ECM Homeostasis in the Nucleus Pulposus Cells.
Chen S, Qin L, Wu X, Fu X, Lin S, Chen D, Xiao G, Shao Z, Cao H
Frontiers in cell and developmental biology 2020;8:127
Frontiers in cell and developmental biology 2020;8:127
The primary cilium and lipophagy translate mechanical forces to direct metabolic adaptation of kidney epithelial cells.
Miceli C, Roccio F, Penalva-Mousset L, Burtin M, Leroy C, Nemazanyy I, Kuperwasser N, Pontoglio M, Friedlander G, Morel E, Terzi F, Codogno P, Dupont N
Nature cell biology 2020 Sep;22(9):1091-1102
Nature cell biology 2020 Sep;22(9):1091-1102
Carbon black nanoparticles induce HDAC6-mediated inflammatory responses in 16HBE cells.
Lin H, Fu G, Yu Q, Wang Z, Zuo Y, Shi Y, Zhang L, Gu Y, Qin L, Zhou T
Toxicology and industrial health 2020 Oct;36(10):759-768
Toxicology and industrial health 2020 Oct;36(10):759-768
Use of patient derived urine renal epithelial cells to confirm pathogenicity of PKHD1 alleles.
Molinari E, Srivastava S, Dewhurst RM, Sayer JA
BMC nephrology 2020 Oct 15;21(1):435
BMC nephrology 2020 Oct 15;21(1):435
O-GlcNAc transferase regulates centriole behavior and intraflagellar transport to promote ciliogenesis.
Yu F, Li T, Sui Y, Chen Q, Yang S, Yang J, Hong R, Li D, Yan X, Zhao W, Zhu X, Zhou J
Protein & cell 2020 Nov;11(11):852-857
Protein & cell 2020 Nov;11(11):852-857
Differentiation of ciliated human midbrain-derived LUHMES neurons.
Lauter G, Coschiera A, Yoshihara M, Sugiaman-Trapman D, Ezer S, Sethurathinam S, Katayama S, Kere J, Swoboda P
Journal of cell science 2020 Nov 9;133(21)
Journal of cell science 2020 Nov 9;133(21)
Mutations in GRK2 cause Jeune syndrome by impairing Hedgehog and canonical Wnt signaling.
Bosakova M, Abraham SP, Nita A, Hruba E, Buchtova M, Taylor SP, Duran I, Martin J, Svozilova K, Barta T, Varecha M, Balek L, Kohoutek J, Radaszkiewicz T, Pusapati GV, Bryja V, Rush ET, Thiffault I, Nickerson DA, Bamshad MJ, University of Washington Center for Mendelian Genomics., Rohatgi R, Cohn DH, Krakow D, Krejci P
EMBO molecular medicine 2020 Nov 6;12(11):e11739
EMBO molecular medicine 2020 Nov 6;12(11):e11739
Primary cilia mediate early life programming of adiposity through lysosomal regulation in the developing mouse hypothalamus.
Lee CH, Song DK, Park CB, Choi J, Kang GM, Shin SH, Kwon I, Park S, Kim S, Kim JY, Dugu H, Park JW, Choi JH, Min SH, Sohn JW, Kim MS
Nature communications 2020 Nov 13;11(1):5772
Nature communications 2020 Nov 13;11(1):5772
Primary cilium remodeling mediates a cell signaling switch in differentiating neurons.
Toro-Tapia G, Das RM
Science advances 2020 May;6(21):eabb0601
Science advances 2020 May;6(21):eabb0601
Genetic interaction of mammalian IFT-A paralogs regulates cilia disassembly, ciliary entry of membrane protein, Hedgehog signaling, and embryogenesis.
Wang W, Allard BA, Pottorf TS, Wang HH, Vivian JL, Tran PV
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 May;34(5):6369-6381
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 May;34(5):6369-6381
ASK1-Mediated Phosphorylation Blocks HDAC6 Ubiquitination and Degradation to Drive the Disassembly of Photoreceptor Connecting Cilia.
Ran J, Liu M, Feng J, Li H, Ma H, Song T, Cao Y, Zhou P, Wu Y, Yang Y, Yang Y, Yu F, Guo H, Zhang L, Xie S, Li D, Gao J, Zhang X, Zhu X, Zhou J
Developmental cell 2020 May 4;53(3):287-299.e5
Developmental cell 2020 May 4;53(3):287-299.e5
SIRT2 Affects Primary Cilia Formation by Regulating mTOR Signaling in Retinal Pigmented Epithelial Cells.
Lim J, Son J, Ryu J, Kim JE
International journal of molecular sciences 2020 Mar 24;21(6)
International journal of molecular sciences 2020 Mar 24;21(6)
Biallelic Mutations in Tetratricopeptide Repeat Domain 26 (Intraflagellar Transport 56) Cause Severe Biliary Ciliopathy in Humans.
Shaheen R, Alsahli S, Ewida N, Alzahrani F, Shamseldin HE, Patel N, Al Qahtani A, Alhebbi H, Alhashem A, Al-Sheddi T, Alomar R, Alobeid E, Abouelhoda M, Monies D, Al-Hussaini A, Alzouman MA, Shagrani M, Faqeih E, Alkuraya FS
Hepatology (Baltimore, Md.) 2020 Jun;71(6):2067-2079
Hepatology (Baltimore, Md.) 2020 Jun;71(6):2067-2079
A novel homozygous mutation in WDR19 induces disorganization of microtubules in sperm flagella and nonsyndromic asthenoteratospermia.
Ni X, Wang J, Lv M, Liu C, Zhong Y, Tian S, Wu H, Cheng H, Gao Y, Tan Q, Chen B, Li Q, Song B, Wei Z, Zhou P, He X, Zhang F, Cao Y
Journal of assisted reproduction and genetics 2020 Jun;37(6):1431-1439
Journal of assisted reproduction and genetics 2020 Jun;37(6):1431-1439
Acute inhibition of centriolar satellite function and positioning reveals their functions at the primary cilium.
Aydin ÖZ, Taflan SO, Gurkaslar C, Firat-Karalar EN
PLoS biology 2020 Jun;18(6):e3000679
PLoS biology 2020 Jun;18(6):e3000679
IFT proteins interact with HSET to promote supernumerary centrosome clustering in mitosis.
Vitre B, Taulet N, Guesdon A, Douanier A, Dosdane A, Cisneros M, Maurin J, Hettinger S, Anguille C, Taschner M, Lorentzen E, Delaval B
EMBO reports 2020 Jun 4;21(6):e49234
EMBO reports 2020 Jun 4;21(6):e49234
Homozygous mutations in DZIP1 can induce asthenoteratospermia with severe MMAF.
Lv M, Liu W, Chi W, Ni X, Wang J, Cheng H, Li WY, Yang S, Wu H, Zhang J, Gao Y, Liu C, Li C, Yang C, Tan Q, Tang D, Zhang J, Song B, Chen YJ, Li Q, Zhong Y, Zhang Z, Saiyin H, Jin L, Xu Y, Zhou P, Wei Z, Zhang C, He X, Zhang F, Cao Y
Journal of medical genetics 2020 Jul;57(7):445-453
Journal of medical genetics 2020 Jul;57(7):445-453
Ciliary proteins specify the cell inflammatory response by tuning NFκB signalling, independently of primary cilia.
Mc Fie M, Koneva L, Collins I, Coveney CR, Clube AM, Chanalaris A, Vincent TL, Bezbradica JS, Sansom SN, Wann AKT
Journal of cell science 2020 Jul 8;133(13)
Journal of cell science 2020 Jul 8;133(13)
Ciliogenesis and Hedgehog signalling are suppressed downstream of KRAS during acinar-ductal metaplasia in mouse.
Bangs FK, Miller P, O'Neill E
Disease models & mechanisms 2020 Jul 30;13(7)
Disease models & mechanisms 2020 Jul 30;13(7)
Requirement of NPHP5 in the hierarchical assembly of basal feet associated with basal bodies of primary cilia.
Hossain D, Barbelanne M, Tsang WY
Cellular and molecular life sciences : CMLS 2020 Jan;77(1):195-212
Cellular and molecular life sciences : CMLS 2020 Jan;77(1):195-212
The association of microcephaly protein WDR62 with CPAP/IFT88 is required for cilia formation and neocortical development.
Shohayeb B, Ho U, Yeap YY, Parton RG, Millard SS, Xu Z, Piper M, Ng DCH
Human molecular genetics 2020 Jan 15;29(2):248-263
Human molecular genetics 2020 Jan 15;29(2):248-263
PI3KC2α-dependent and VPS34-independent generation of PI3P controls primary cilium-mediated autophagy in response to shear stress.
Boukhalfa A, Nascimbeni AC, Ramel D, Dupont N, Hirsch E, Gayral S, Laffargue M, Codogno P, Morel E
Nature communications 2020 Jan 15;11(1):294
Nature communications 2020 Jan 15;11(1):294
Aldosterone controls primary cilium length and cell size in renal collecting duct principal cells.
Komarynets O, Chassot A, Bernabeu E, Czogalla J, Roth I, Liaudet N, Prodon F, Loffing J, Feraille E
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Feb;34(2):2625-2640
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Feb;34(2):2625-2640
NRF2 negatively regulates primary ciliogenesis and hedgehog signaling.
Liu P, Dodson M, Fang D, Chapman E, Zhang DD
PLoS biology 2020 Feb;18(2):e3000620
PLoS biology 2020 Feb;18(2):e3000620
Altered gene regulation as a candidate mechanism by which ciliopathy gene SDCCAG8 contributes to schizophrenia and cognitive function.
Flynn M, Whitton L, Donohoe G, Morrison CG, Morris DW
Human molecular genetics 2020 Feb 1;29(3):407-417
Human molecular genetics 2020 Feb 1;29(3):407-417
DIAPH1 regulates ciliogenesis and trafficking in primary cilia.
Palander O, Trimble WS
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Dec;34(12):16516-16535
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Dec;34(12):16516-16535
Low fluid shear stress promoted ciliogenesis via Dvl2 in hUVECs.
Sheng X, Sheng Y, Gao S, Fan F, Wang J
Histochemistry and cell biology 2020 Dec;154(6):639-654
Histochemistry and cell biology 2020 Dec;154(6):639-654
Exploratory neuroimmune profiling identifies CNS-specific alterations in COVID-19 patients with neurological involvement.
Song E, Bartley CM, Chow RD, Ngo TT, Jiang R, Zamecnik CR, Dandekar R, Loudermilk RP, Dai Y, Liu F, Hawes IA, Alvarenga BD, Huynh T, McAlpine L, Rahman NT, Geng B, Chiarella J, Goldman-Israelow B, Vogels CBF, Grubaugh ND, Casanovas-Massana A, Phinney BS, Salemi M, Alexander J, Gallego JA, Lencz T, Walsh H, Lucas C, Klein J, Mao T, Oh J, Ring A, Spudich S, Ko AI, Kleinstein SH, DeRisi JL, Iwasaki A, Pleasure SJ, Wilson MR, Farhadian SF
bioRxiv : the preprint server for biology 2020 Dec 9;
bioRxiv : the preprint server for biology 2020 Dec 9;
The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis.
Yoshida S, Aoki K, Fujiwara K, Nakakura T, Kawamura A, Yamada K, Ono M, Yogosawa S, Yoshida K
eLife 2020 Aug 6;9
eLife 2020 Aug 6;9
Primary Cilia Mediate Wnt5a/β-catenin Signaling to Regulate Adipogenic Differentiation of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Following Calcium Induction.
Bae YK, Kim GH, Kwon JH, Kim M, Choi SJ, Oh W, Um S, Jin HJ
Tissue engineering and regenerative medicine 2020 Apr;17(2):193-202
Tissue engineering and regenerative medicine 2020 Apr;17(2):193-202
Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration.
Kim Y, Lee J, Seppala M, Cobourne MT, Kim SH
Nature communications 2020 Apr 24;11(1):1994
Nature communications 2020 Apr 24;11(1):1994
Primary cilia control glucose homeostasis via islet paracrine interactions.
Hughes JW, Cho JH, Conway HE, DiGruccio MR, Ng XW, Roseman HF, Abreu D, Urano F, Piston DW
Proceedings of the National Academy of Sciences of the United States of America 2020 Apr 21;117(16):8912-8923
Proceedings of the National Academy of Sciences of the United States of America 2020 Apr 21;117(16):8912-8923
The primary cilium dampens proliferative signaling and represses a G2/M transcriptional network in quiescent myoblasts.
Venugopal N, Ghosh A, Gala H, Aloysius A, Vyas N, Dhawan J
BMC molecular and cell biology 2020 Apr 15;21(1):25
BMC molecular and cell biology 2020 Apr 15;21(1):25
Primary Cilia Blockage Promotes the Malignant Behaviors of Hepatocellular Carcinoma via Induction of Autophagy.
Liu L, Sheng JQ, Wang MR, Gan Y, Wu XL, Liao JZ, Tian DA, He XX, Li PY
BioMed research international 2019;2019:5202750
BioMed research international 2019;2019:5202750
661W Photoreceptor Cell Line as a Cell Model for Studying Retinal Ciliopathies.
Wheway G, Nazlamova L, Turner D, Cross S
Frontiers in genetics 2019;10:308
Frontiers in genetics 2019;10:308
NRF2-dependent gene expression promotes ciliogenesis and Hedgehog signaling.
Martin-Hurtado A, Martin-Morales R, Robledinos-Antón N, Blanco R, Palacios-Blanco I, Lastres-Becker I, Cuadrado A, Garcia-Gonzalo FR
Scientific reports 2019 Sep 25;9(1):13896
Scientific reports 2019 Sep 25;9(1):13896
Requirement of IFT-B-BBSome complex interaction in export of GPR161 from cilia.
Nozaki S, Castro Araya RF, Katoh Y, Nakayama K
Biology open 2019 Sep 17;8(9)
Biology open 2019 Sep 17;8(9)
A Smo/Gli Multitarget Hedgehog Pathway Inhibitor Impairs Tumor Growth.
Lospinoso Severini L, Quaglio D, Basili I, Ghirga F, Bufalieri F, Caimano M, Balducci S, Moretti M, Romeo I, Loricchio E, Maroder M, Botta B, Mori M, Infante P, Di Marcotullio L
Cancers 2019 Oct 9;11(10)
Cancers 2019 Oct 9;11(10)
Phosphorylation of CEP83 by TTBK2 is necessary for cilia initiation.
Lo CH, Lin IH, Yang TT, Huang YC, Tanos BE, Chou PC, Chang CW, Tsay YG, Liao JC, Wang WJ
The Journal of cell biology 2019 Oct 7;218(10):3489-3505
The Journal of cell biology 2019 Oct 7;218(10):3489-3505
Nucleus pulposus primary cilia alter their length in response to changes in extracellular osmolarity but do not control TonEBP-mediated osmoregulation.
Choi H, Madhu V, Shapiro IM, Risbud MV
Scientific reports 2019 Oct 29;9(1):15469
Scientific reports 2019 Oct 29;9(1):15469
Fetuin-A Inhibits Placental Cell Growth and Ciliogenesis in Gestational Diabetes Mellitus.
Wang CY, Su MT, Cheng HL, Kuo PL, Tsai PY
International journal of molecular sciences 2019 Oct 21;20(20)
International journal of molecular sciences 2019 Oct 21;20(20)
Ciliogenesis-coupled accumulation of IFT-B proteins in a novel cytoplasmic compartment.
Lamri L, Twan WK, Katoh TA, Botilde Y, Takaoka K, Ikawa Y, Nishimura H, Fukumoto A, Minegishi K, Mizuno K, Hamada H
Genes to cells : devoted to molecular & cellular mechanisms 2019 Nov;24(11):731-745
Genes to cells : devoted to molecular & cellular mechanisms 2019 Nov;24(11):731-745
C11ORF74 interacts with the IFT-A complex and participates in ciliary BBSome localization.
Takahara M, Kunii M, Nakamura K, Harada A, Hirano T, Katoh Y, Nakayama K
Journal of biochemistry 2019 Mar 1;165(3):257-267
Journal of biochemistry 2019 Mar 1;165(3):257-267
Centriolar satellites are required for efficient ciliogenesis and ciliary content regulation.
Odabasi E, Gul S, Kavakli IH, Firat-Karalar EN
EMBO reports 2019 Jun;20(6)
EMBO reports 2019 Jun;20(6)
Extraciliary roles of the ciliopathy protein JBTS17 in mitosis and neurogenesis.
Hong H, Joo K, Park SM, Seo J, Kim MH, Shin E, Cheong HI, Lee JH, Kim J
Annals of neurology 2019 Jul;86(1):99-115
Annals of neurology 2019 Jul;86(1):99-115
Chloroquine inhibits human retina pigmented epithelial cell growth and microtubule nucleation by downregulating p150glued.
Chen TY, Lien WC, Cheng HL, Kuan TS, Sheu SY, Wang CY
Journal of cellular physiology 2019 Jul;234(7):10445-10457
Journal of cellular physiology 2019 Jul;234(7):10445-10457
IFT88 controls NuMA enrichment at k-fibers minus-ends to facilitate their re-anchoring into mitotic spindles.
Taulet N, Douanier A, Vitre B, Anguille C, Maurin J, Dromard Y, Georget V, Delaval B
Scientific reports 2019 Jul 16;9(1):10311
Scientific reports 2019 Jul 16;9(1):10311
Type I collagen-induced YAP nuclear expression promotes primary cilia growth and contributes to cell migration in confluent mouse embryo fibroblast 3T3-L1 cells.
Xu Q, Liu X, Liu W, Hayashi T, Yamato M, Fujisaki H, Hattori S, Tashiro SI, Onodera S, Ikejima T
Molecular and cellular biochemistry 2019 Jan;450(1-2):87-96
Molecular and cellular biochemistry 2019 Jan;450(1-2):87-96
Malformations in the Murine Kidney Caused by Loss of CENP-F Function.
Haley CO, Waters AM, Bader DM
Anatomical record (Hoboken, N.J. : 2007) 2019 Jan;302(1):163-170
Anatomical record (Hoboken, N.J. : 2007) 2019 Jan;302(1):163-170
Atoh1 Controls Primary Cilia Formation to Allow for SHH-Triggered Granule Neuron Progenitor Proliferation.
Chang CH, Zanini M, Shirvani H, Cheng JS, Yu H, Feng CH, Mercier AL, Hung SY, Forget A, Wang CH, Cigna SM, Lu IL, Chen WY, Leboucher S, Wang WJ, Ruat M, Spassky N, Tsai JW, Ayrault O
Developmental cell 2019 Jan 28;48(2):184-199.e5
Developmental cell 2019 Jan 28;48(2):184-199.e5
Expansion microscopy for the analysis of centrioles and cilia.
Sahabandu N, Kong D, Magidson V, Nanjundappa R, Sullenberger C, Mahjoub MR, Loncarek J
Journal of microscopy 2019 Dec;276(3):145-159
Journal of microscopy 2019 Dec;276(3):145-159
Primary cilia mediate mitochondrial stress responses to promote dopamine neuron survival in a Parkinson's disease model.
Bae JE, Kang GM, Min SH, Jo DS, Jung YK, Kim K, Kim MS, Cho DH
Cell death & disease 2019 Dec 16;10(12):952
Cell death & disease 2019 Dec 16;10(12):952
Glucose homeostasis is regulated by pancreatic β-cell cilia via endosomal EphA-processing.
Volta F, Scerbo MJ, Seelig A, Wagner R, O'Brien N, Gerst F, Fritsche A, Häring HU, Zeigerer A, Ullrich S, Gerdes JM
Nature communications 2019 Dec 12;10(1):5686
Nature communications 2019 Dec 12;10(1):5686
Cilia function is associated with axon initial segment morphology.
Wang B, Hu L, Sun Z, Zhang Y
Biochemical and biophysical research communications 2019 Aug 13;516(1):15-21
Biochemical and biophysical research communications 2019 Aug 13;516(1):15-21
A CEP104-CSPP1 Complex Is Required for Formation of Primary Cilia Competent in Hedgehog Signaling.
Frikstad KM, Molinari E, Thoresen M, Ramsbottom SA, Hughes F, Letteboer SJF, Gilani S, Schink KO, Stokke T, Geimer S, Pedersen LB, Giles RH, Akhmanova A, Roepman R, Sayer JA, Patzke S
Cell reports 2019 Aug 13;28(7):1907-1922.e6
Cell reports 2019 Aug 13;28(7):1907-1922.e6
Failure to reabsorb the primary cilium induces cellular senescence.
Jeffries EP, Di Filippo M, Galbiati F
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Apr;33(4):4866-4882
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Apr;33(4):4866-4882
Bi-allelic Mutations in FAM149B1 Cause Abnormal Primary Cilium and a Range of Ciliopathy Phenotypes in Humans.
Shaheen R, Jiang N, Alzahrani F, Ewida N, Al-Sheddi T, Alobeid E, Musaev D, Stanley V, Hashem M, Ibrahim N, Abdulwahab F, Alshenqiti A, Sonmez FM, Saqati N, Alzaidan H, Al-Qattan MM, Al-Mohanna F, Gleeson JG, Alkuraya FS
American journal of human genetics 2019 Apr 4;104(4):731-737
American journal of human genetics 2019 Apr 4;104(4):731-737
Cellular ciliary phenotyping indicates pathogenicity of novel variants in IFT140 and confirms a Mainzer-Saldino syndrome diagnosis.
Oud MM, Latour BL, Bakey Z, Letteboer SJ, Lugtenberg D, Wu KM, Cornelissen EAM, Yntema HG, Schmidts M, Roepman R, Bongers EMHF
Cilia 2018;7:1
Cilia 2018;7:1
A distal centriolar protein network controls organelle maturation and asymmetry.
Wang L, Failler M, Fu W, Dynlacht BD
Nature communications 2018 Sep 26;9(1):3938
Nature communications 2018 Sep 26;9(1):3938
Characterization of Primary Cilia in Normal Fallopian Tube Epithelium and Serous Tubal Intraepithelial Carcinoma.
Abdelhamed ZA, Ryan TA, Fuller M, Coulson-Gilmer C, Abdelmottaleb DI, Wang TL, Kaun JC, Wang P, Hutson R, Wilkinson N, Bell SM, Johnson CA
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2018 Oct;28(8):1535-1544
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2018 Oct;28(8):1535-1544
Dynein-2 intermediate chains play crucial but distinct roles in primary cilia formation and function.
Vuolo L, Stevenson NL, Heesom KJ, Stephens DJ
eLife 2018 Oct 16;7
eLife 2018 Oct 16;7
Primary cilia sensitize endothelial cells to BMP and prevent excessive vascular regression.
Vion AC, Alt S, Klaus-Bergmann A, Szymborska A, Zheng T, Perovic T, Hammoutene A, Oliveira MB, Bartels-Klein E, Hollfinger I, Rautou PE, Bernabeu MO, Gerhardt H
The Journal of cell biology 2018 May 7;217(5):1651-1665
The Journal of cell biology 2018 May 7;217(5):1651-1665
The Joubert syndrome protein ARL13B binds tubulin to maintain uniform distribution of proteins along the ciliary membrane.
Revenkova E, Liu Q, Gusella GL, Iomini C
Journal of cell science 2018 May 4;131(9)
Journal of cell science 2018 May 4;131(9)
Patient-iPSC-Derived Kidney Organoids Show Functional Validation of a Ciliopathic Renal Phenotype and Reveal Underlying Pathogenetic Mechanisms.
Forbes TA, Howden SE, Lawlor K, Phipson B, Maksimovic J, Hale L, Wilson S, Quinlan C, Ho G, Holman K, Bennetts B, Crawford J, Trnka P, Oshlack A, Patel C, Mallett A, Simons C, Little MH
American journal of human genetics 2018 May 3;102(5):816-831
American journal of human genetics 2018 May 3;102(5):816-831
Cell type-specific regulation of ciliary transition zone assembly in vertebrates.
Wiegering A, Dildrop R, Kalfhues L, Spychala A, Kuschel S, Lier JM, Zobel T, Dahmen S, Leu T, Struchtrup A, Legendre F, Vesque C, Schneider-Maunoury S, Saunier S, Rüther U, Gerhardt C
The EMBO journal 2018 May 15;37(10)
The EMBO journal 2018 May 15;37(10)
Inhibition of Hedgehog signaling suppresses proliferation and microcyst formation of human Autosomal Dominant Polycystic Kidney Disease cells.
Silva LM, Jacobs DT, Allard BA, Fields TA, Sharma M, Wallace DP, Tran PV
Scientific reports 2018 Mar 21;8(1):4985
Scientific reports 2018 Mar 21;8(1):4985
Primary Cilia Mediate Diverse Kinase Inhibitor Resistance Mechanisms in Cancer.
Jenks AD, Vyse S, Wong JP, Kostaras E, Keller D, Burgoyne T, Shoemark A, Tsalikis A, de la Roche M, Michaelis M, Cinatl J Jr, Huang PH, Tanos BE
Cell reports 2018 Jun 5;23(10):3042-3055
Cell reports 2018 Jun 5;23(10):3042-3055
TSC1 and TSC2 regulate cilia length and canonical Hedgehog signaling via different mechanisms.
Rosengren T, Larsen LJ, Pedersen LB, Christensen ST, Møller LB
Cellular and molecular life sciences : CMLS 2018 Jul;75(14):2663-2680
Cellular and molecular life sciences : CMLS 2018 Jul;75(14):2663-2680
IFT88 mutations identified in individuals with non-syndromic recessive retinal degeneration result in abnormal ciliogenesis.
Chekuri A, Guru AA, Biswas P, Branham K, Borooah S, Soto-Hermida A, Hicks M, Khan NW, Matsui H, Alapati A, Raghavendra PB, Roosing S, Sarangapani S, Mathavan S, Telenti A, Heckenlively JR, Riazuddin SA, Frazer KA, Sieving PA, Ayyagari R
Human genetics 2018 Jul;137(6-7):447-458
Human genetics 2018 Jul;137(6-7):447-458
Super-Resolution Imaging Reveals TCTN2 Depletion-Induced IFT88 Lumen Leakage and Ciliary Weakening.
Weng RR, Yang TT, Huang CE, Chang CW, Wang WJ, Liao JC
Biophysical journal 2018 Jul 17;115(2):263-275
Biophysical journal 2018 Jul 17;115(2):263-275
Interaction of WDR60 intermediate chain with TCTEX1D2 light chain of the dynein-2 complex is crucial for ciliary protein trafficking.
Hamada Y, Tsurumi Y, Nozaki S, Katoh Y, Nakayama K
Molecular biology of the cell 2018 Jul 1;29(13):1628-1639
Molecular biology of the cell 2018 Jul 1;29(13):1628-1639
Drug-induced ciliogenesis in pancreatic cancer cells is facilitated by the secreted ATP-purinergic receptor signaling pathway.
Khan NA, Garg AD, Agostinis P, Swinnen JV
Oncotarget 2018 Jan 9;9(3):3507-3518
Oncotarget 2018 Jan 9;9(3):3507-3518
Glucose deprivation induces primary cilium formation through mTORC1 inactivation.
Takahashi K, Nagai T, Chiba S, Nakayama K, Mizuno K
Journal of cell science 2018 Jan 8;131(1)
Journal of cell science 2018 Jan 8;131(1)
CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function.
Canning P, Park K, Gonçalves J, Li C, Howard CJ, Sharpe TD, Holt LJ, Pelletier L, Bullock AN, Leroux MR
Cell reports 2018 Jan 23;22(4):885-894
Cell reports 2018 Jan 23;22(4):885-894
The small GTPase RSG1 controls a final step in primary cilia initiation.
Agbu SO, Liang Y, Liu A, Anderson KV
The Journal of cell biology 2018 Jan 2;217(1):413-427
The Journal of cell biology 2018 Jan 2;217(1):413-427
IFT20 modulates ciliary PDGFRα signaling by regulating the stability of Cbl E3 ubiquitin ligases.
Schmid FM, Schou KB, Vilhelm MJ, Holm MS, Breslin L, Farinelli P, Larsen LA, Andersen JS, Pedersen LB, Christensen ST
The Journal of cell biology 2018 Jan 2;217(1):151-161
The Journal of cell biology 2018 Jan 2;217(1):151-161
Cilia loss sensitizes cells to transformation by activating the mevalonate pathway.
Deng YZ, Cai Z, Shi S, Jiang H, Shang YR, Ma N, Wang JJ, Guan DX, Chen TW, Rong YF, Qian ZY, Zhang EB, Feng D, Zhou QL, Du YN, Liu DP, Huang XX, Liu LM, Chin E, Li DS, Wang XF, Zhang XL, Xie D
The Journal of experimental medicine 2018 Jan 2;215(1):177-195
The Journal of experimental medicine 2018 Jan 2;215(1):177-195
Constitutively-active FGFR3 disrupts primary cilium length and IFT20 trafficking in various chondrocyte models of achondroplasia.
Martin L, Kaci N, Estibals V, Goudin N, Garfa-Traore M, Benoist-Lasselin C, Dambroise E, Legeai-Mallet L
Human molecular genetics 2018 Jan 1;27(1):1-13
Human molecular genetics 2018 Jan 1;27(1):1-13
Export of membrane proteins from the Golgi complex to the primary cilium requires the kinesin motor, KIFC1.
Lee SH, Joo K, Jung EJ, Hong H, Seo J, Kim J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Feb;32(2):957-968
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Feb;32(2):957-968
DNAAF1 links heart laterality with the AAA+ ATPase RUVBL1 and ciliary intraflagellar transport.
Hartill VL, van de Hoek G, Patel MP, Little R, Watson CM, Berry IR, Shoemark A, Abdelmottaleb D, Parkes E, Bacchelli C, Szymanska K, Knoers NV, Scambler PJ, Ueffing M, Boldt K, Yates R, Winyard PJ, Adler B, Moya E, Hattingh L, Shenoy A, Hogg C, Sheridan E, Roepman R, Norris D, Mitchison HM, Giles RH, Johnson CA
Human molecular genetics 2018 Feb 1;27(3):529-545
Human molecular genetics 2018 Feb 1;27(3):529-545
Ciliopathy-associated mutations of IFT122 impair ciliary protein trafficking but not ciliogenesis.
Takahara M, Katoh Y, Nakamura K, Hirano T, Sugawa M, Tsurumi Y, Nakayama K
Human molecular genetics 2018 Feb 1;27(3):516-528
Human molecular genetics 2018 Feb 1;27(3):516-528
Spinocerebellar ataxia type 11-associated alleles of Ttbk2 dominantly interfere with ciliogenesis and cilium stability.
Bowie E, Norris R, Anderson KV, Goetz SC
PLoS genetics 2018 Dec;14(12):e1007844
PLoS genetics 2018 Dec;14(12):e1007844
Kinesin-2 and IFT-A act as a complex promoting nuclear localization of β-catenin during Wnt signalling.
Vuong LT, Iomini C, Balmer S, Esposito D, Aaronson SA, Mlodzik M
Nature communications 2018 Dec 13;9(1):5304
Nature communications 2018 Dec 13;9(1):5304
Microtubule asters anchored by FSD1 control axoneme assembly and ciliogenesis.
Tu HQ, Qin XH, Liu ZB, Song ZQ, Hu HB, Zhang YC, Chang Y, Wu M, Huang Y, Bai YF, Wang G, Han QY, Li AL, Zhou T, Liu F, Zhang XM, Li HY
Nature communications 2018 Dec 11;9(1):5277
Nature communications 2018 Dec 11;9(1):5277
Loss-of-function of IFT88 determines metabolic phenotypes in thyroid cancer.
Lee J, Yi S, Won M, Song YS, Yi HS, Park YJ, Park KC, Kim JT, Chang JY, Lee MJ, Sul HJ, Choi JE, Kim KS, Kero J, Kim J, Shong M
Oncogene 2018 Aug;37(32):4455-4474
Oncogene 2018 Aug;37(32):4455-4474
Interaction of heterotrimeric kinesin-II with IFT-B-connecting tetramer is crucial for ciliogenesis.
Funabashi T, Katoh Y, Okazaki M, Sugawa M, Nakayama K
The Journal of cell biology 2018 Aug 6;217(8):2867-2876
The Journal of cell biology 2018 Aug 6;217(8):2867-2876
CFAP70 Is a Novel Axoneme-Binding Protein That Localizes at the Base of the Outer Dynein Arm and Regulates Ciliary Motility.
Shamoto N, Narita K, Kubo T, Oda T, Takeda S
Cells 2018 Aug 29;7(9)
Cells 2018 Aug 29;7(9)
FGFR1-mediated protocadherin-15 loading mediates cargo specificity during intraflagellar transport in inner ear hair-cell kinocilia.
Honda A, Kita T, Seshadri SV, Misaki K, Ahmed Z, Ladbury JE, Richardson GP, Yonemura S, Ladher RK
Proceedings of the National Academy of Sciences of the United States of America 2018 Aug 14;115(33):8388-8393
Proceedings of the National Academy of Sciences of the United States of America 2018 Aug 14;115(33):8388-8393
Cilia-localized LKB1 regulates chemokine signaling, macrophage recruitment, and tissue homeostasis in the kidney.
Viau A, Bienaimé F, Lukas K, Todkar AP, Knoll M, Yakulov TA, Hofherr A, Kretz O, Helmstädter M, Reichardt W, Braeg S, Aschman T, Merkle A, Pfeifer D, Dumit VI, Gubler MC, Nitschke R, Huber TB, Terzi F, Dengjel J, Grahammer F, Köttgen M, Busch H, Boerries M, Walz G, Triantafyllopoulou A, Kuehn EW
The EMBO journal 2018 Aug 1;37(15)
The EMBO journal 2018 Aug 1;37(15)
Basal exon skipping and nonsense-associated altered splicing allows bypassing complete CEP290 loss-of-function in individuals with unusually mild retinal disease.
Barny I, Perrault I, Michel C, Soussan M, Goudin N, Rio M, Thomas S, Attié-Bitach T, Hamel C, Dollfus H, Kaplan J, Rozet JM, Gerard X
Human molecular genetics 2018 Aug 1;27(15):2689-2702
Human molecular genetics 2018 Aug 1;27(15):2689-2702
Robust interaction of IFT70 with IFT52-IFT88 in the IFT-B complex is required for ciliogenesis.
Takei R, Katoh Y, Nakayama K
Biology open 2018 Apr 30;7(5)
Biology open 2018 Apr 30;7(5)
Centrobin controls primary ciliogenesis in vertebrates.
Ogungbenro YA, Tena TC, Gaboriau D, Lalor P, Dockery P, Philipp M, Morrison CG
The Journal of cell biology 2018 Apr 2;217(4):1205-1215
The Journal of cell biology 2018 Apr 2;217(4):1205-1215
Fixation methods can differentially affect ciliary protein immunolabeling.
Hua K, Ferland RJ
Cilia 2017;6:5
Cilia 2017;6:5
iTRAQ-Based Proteomic Analysis of Neonatal Kidney from Offspring of Protein Restricted Rats Reveals Abnormalities in Intraflagellar Transport Proteins.
Liu X, Wang J, Gao L, Liu H, Liu C
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;44(1):185-199
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;44(1):185-199
The Meckel syndrome- associated protein MKS1 functionally interacts with components of the BBSome and IFT complexes to mediate ciliary trafficking and hedgehog signaling.
Goetz SC, Bangs F, Barrington CL, Katsanis N, Anderson KV
PloS one 2017;12(3):e0173399
PloS one 2017;12(3):e0173399
Missense mutations in the WD40 domain of AHI1 cause non-syndromic retinitis pigmentosa.
Nguyen TT, Hull S, Roepman R, van den Born LI, Oud MM, de Vrieze E, Hetterschijt L, Letteboer SJF, van Beersum SEC, Blokland EA, Yntema HG, Cremers FPM, van der Zwaag PA, Arno G, van Wijk E, Webster AR, Haer-Wigman L
Journal of medical genetics 2017 Sep;54(9):624-632
Journal of medical genetics 2017 Sep;54(9):624-632
The ciliary membrane-associated proteome reveals actin-binding proteins as key components of cilia.
Kohli P, Höhne M, Jüngst C, Bertsch S, Ebert LK, Schauss AC, Benzing T, Rinschen MM, Schermer B
EMBO reports 2017 Sep;18(9):1521-1535
EMBO reports 2017 Sep;18(9):1521-1535
Serotonin 5-HT6 receptors affect cognition in a mouse model of Alzheimer's disease by regulating cilia function.
Hu L, Wang B, Zhang Y
Alzheimer's research & therapy 2017 Sep 20;9(1):76
Alzheimer's research & therapy 2017 Sep 20;9(1):76
BBSome function is required for both the morphogenesis and maintenance of the photoreceptor outer segment.
Hsu Y, Garrison JE, Kim G, Schmitz AR, Searby CC, Zhang Q, Datta P, Nishimura DY, Seo S, Sheffield VC
PLoS genetics 2017 Oct;13(10):e1007057
PLoS genetics 2017 Oct;13(10):e1007057
Inter-dependent apical microtubule and actin dynamics orchestrate centrosome retention and neuronal delamination.
Kasioulis I, Das RM, Storey KG
eLife 2017 Oct 23;6
eLife 2017 Oct 23;6
Microtubule stabilization drives 3D centrosome migration to initiate primary ciliogenesis.
Pitaval A, Senger F, Letort G, Gidrol X, Guyon L, Sillibourne J, Théry M
The Journal of cell biology 2017 Nov 6;216(11):3713-3728
The Journal of cell biology 2017 Nov 6;216(11):3713-3728
USP9X counteracts differential ubiquitination of NPHP5 by MARCH7 and BBS11 to regulate ciliogenesis.
Das A, Qian J, Tsang WY
PLoS genetics 2017 May;13(5):e1006791
PLoS genetics 2017 May;13(5):e1006791
Identification of Elongated Primary Cilia with Impaired Mechanotransduction in Idiopathic Scoliosis Patients.
Oliazadeh N, Gorman KF, Eveleigh R, Bourque G, Moreau A
Scientific reports 2017 Mar 14;7:44260
Scientific reports 2017 Mar 14;7:44260
Ciliary entry of KIF17 is dependent on its binding to the IFT-B complex via IFT46-IFT56 as well as on its nuclear localization signal.
Funabashi T, Katoh Y, Michisaka S, Terada M, Sugawa M, Nakayama K
Molecular biology of the cell 2017 Mar 1;28(5):624-633
Molecular biology of the cell 2017 Mar 1;28(5):624-633
Primary Cilium-Regulated EG-VEGF Signaling Facilitates Trophoblast Invasion.
Wang CY, Tsai HL, Syu JS, Chen TY, Su MT
Journal of cellular physiology 2017 Jun;232(6):1467-1477
Journal of cellular physiology 2017 Jun;232(6):1467-1477
Mutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease.
Lu H, Galeano MCR, Ott E, Kaeslin G, Kausalya PJ, Kramer C, Ortiz-Brüchle N, Hilger N, Metzis V, Hiersche M, Tay SY, Tunningley R, Vij S, Courtney AD, Whittle B, Wühl E, Vester U, Hartleben B, Neuber S, Frank V, Little MH, Epting D, Papathanasiou P, Perkins AC, Wright GD, Hunziker W, Gee HY, Otto EA, Zerres K, Hildebrandt F, Roy S, Wicking C, Bergmann C
Nature genetics 2017 Jul;49(7):1025-1034
Nature genetics 2017 Jul;49(7):1025-1034
NEK7 is required for G1 progression and procentriole formation.
Gupta A, Tsuchiya Y, Ohta M, Shiratsuchi G, Kitagawa D
Molecular biology of the cell 2017 Jul 15;28(15):2123-2134
Molecular biology of the cell 2017 Jul 15;28(15):2123-2134
DGKδ triggers endoplasmic reticulum release of IFT88-containing vesicles destined for the assembly of primary cilia.
Ding J, Shao L, Yao Y, Tong X, Liu H, Yue S, Xie L, Cheng SY
Scientific reports 2017 Jul 13;7(1):5296
Scientific reports 2017 Jul 13;7(1):5296
In Vitro Modeling Using Ciliopathy-Patient-Derived Cells Reveals Distinct Cilia Dysfunctions Caused by CEP290 Mutations.
Shimada H, Lu Q, Insinna-Kettenhofen C, Nagashima K, English MA, Semler EM, Mahgerefteh J, Cideciyan AV, Li T, Brooks BP, Gunay-Aygun M, Jacobson SG, Cogliati T, Westlake CJ, Swaroop A
Cell reports 2017 Jul 11;20(2):384-396
Cell reports 2017 Jul 11;20(2):384-396
The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base.
Kanie T, Abbott KL, Mooney NA, Plowey ED, Demeter J, Jackson PK
Developmental cell 2017 Jul 10;42(1):22-36.e12
Developmental cell 2017 Jul 10;42(1):22-36.e12
Primary cilia control the maturation of tubular lumen in renal collecting duct epithelium.
Ernandez T, Komarynets O, Chassot A, Sougoumarin S, Soulié P, Wang Y, Montesano R, Feraille E
American journal of physiology. Cell physiology 2017 Jul 1;313(1):C94-C107
American journal of physiology. Cell physiology 2017 Jul 1;313(1):C94-C107
KIF13B establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling.
Schou KB, Mogensen JB, Morthorst SK, Nielsen BS, Aleliunaite A, Serra-Marques A, Fürstenberg N, Saunier S, Bizet AA, Veland IR, Akhmanova A, Christensen ST, Pedersen LB
Nature communications 2017 Jan 30;8:14177
Nature communications 2017 Jan 30;8:14177
Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision.
Phua SC, Chiba S, Suzuki M, Su E, Roberson EC, Pusapati GV, Schurmans S, Setou M, Rohatgi R, Reiter JF, Ikegami K, Inoue T
Cell 2017 Jan 12;168(1-2):264-279.e15
Cell 2017 Jan 12;168(1-2):264-279.e15
HDAC2 promotes loss of primary cilia in pancreatic ductal adenocarcinoma.
Kobayashi T, Nakazono K, Tokuda M, Mashima Y, Dynlacht BD, Itoh H
EMBO reports 2017 Feb;18(2):334-343
EMBO reports 2017 Feb;18(2):334-343
Regulation of ciliary retrograde protein trafficking by the Joubert syndrome proteins ARL13B and INPP5E.
Nozaki S, Katoh Y, Terada M, Michisaka S, Funabashi T, Takahashi S, Kontani K, Nakayama K
Journal of cell science 2017 Feb 1;130(3):563-576
Journal of cell science 2017 Feb 1;130(3):563-576
IFT proteins spatially control the geometry of cleavage furrow ingression and lumen positioning.
Taulet N, Vitre B, Anguille C, Douanier A, Rocancourt M, Taschner M, Lorentzen E, Echard A, Delaval B
Nature communications 2017 Dec 4;8(1):1928
Nature communications 2017 Dec 4;8(1):1928
mTORC1-Mediated Inhibition of 4EBP1 Is Essential for Hedgehog Signaling-Driven Translation and Medulloblastoma.
Wu CC, Hou S, Orr BA, Kuo BR, Youn YH, Ong T, Roth F, Eberhart CG, Robinson GW, Solecki DJ, Taketo MM, Gilbertson RJ, Roussel MF, Han YG
Developmental cell 2017 Dec 18;43(6):673-688.e5
Developmental cell 2017 Dec 18;43(6):673-688.e5
A mutation in IFT43 causes non-syndromic recessive retinal degeneration.
Biswas P, Duncan JL, Ali M, Matsui H, Naeem MA, Raghavendra PB, Frazer KA, Arts HH, Riazuddin S, Akram J, Hejtmancik JF, Riazuddin SA, Ayyagari R
Human molecular genetics 2017 Dec 1;26(23):4741-4751
Human molecular genetics 2017 Dec 1;26(23):4741-4751
A human patient-derived cellular model of Joubert syndrome reveals ciliary defects which can be rescued with targeted therapies.
Srivastava S, Ramsbottom SA, Molinari E, Alkanderi S, Filby A, White K, Henry C, Saunier S, Miles CG, Sayer JA
Human molecular genetics 2017 Dec 1;26(23):4657-4667
Human molecular genetics 2017 Dec 1;26(23):4657-4667
A novel role for primary cilia in airway remodeling.
Trempus CS, Song W, Lazrak A, Yu Z, Creighton JR, Young BM, Heise RL, Yu YR, Ingram JL, Tighe RM, Matalon S, Garantziotis S
American journal of physiology. Lung cellular and molecular physiology 2017 Aug 1;313(2):L328-L338
American journal of physiology. Lung cellular and molecular physiology 2017 Aug 1;313(2):L328-L338
KDM3A coordinates actin dynamics with intraflagellar transport to regulate cilia stability.
Yeyati PL, Schiller R, Mali G, Kasioulis I, Kawamura A, Adams IR, Playfoot C, Gilbert N, van Heyningen V, Wills J, von Kriegsheim A, Finch A, Sakai J, Schofield CJ, Jackson IJ, Mill P
The Journal of cell biology 2017 Apr 3;216(4):999-1013
The Journal of cell biology 2017 Apr 3;216(4):999-1013
IFT56 regulates vertebrate developmental patterning by maintaining IFTB complex integrity and ciliary microtubule architecture.
Xin D, Christopher KJ, Zeng L, Kong Y, Weatherbee SD
Development (Cambridge, England) 2017 Apr 15;144(8):1544-1553
Development (Cambridge, England) 2017 Apr 15;144(8):1544-1553
Practical method for targeted disruption of cilia-related genes by using CRISPR/Cas9-mediated, homology-independent knock-in system.
Katoh Y, Michisaka S, Nozaki S, Funabashi T, Hirano T, Takei R, Nakayama K
Molecular biology of the cell 2017 Apr 1;28(7):898-906
Molecular biology of the cell 2017 Apr 1;28(7):898-906
STED and STORM Superresolution Imaging of Primary Cilia.
Yang TT, Chong WM, Liao JC
Methods in molecular biology (Clifton, N.J.) 2016;1454:169-92
Methods in molecular biology (Clifton, N.J.) 2016;1454:169-92
Immunofluorescent staining of septins in primary cilia.
Kim MS, Froese CD, Xie H, Trimble WS
Methods in cell biology 2016;136:269-83
Methods in cell biology 2016;136:269-83
Destabilization of the IFT-B cilia core complex due to mutations in IFT81 causes a Spectrum of Short-Rib Polydactyly Syndrome.
Duran I, Taylor SP, Zhang W, Martin J, Forlenza KN, Spiro RP, Nickerson DA, Bamshad M, Cohn DH, Krakow D
Scientific reports 2016 Sep 26;6:34232
Scientific reports 2016 Sep 26;6:34232
A Conserved Role for Girdin in Basal Body Positioning and Ciliogenesis.
Nechipurenko IV, Olivier-Mason A, Kazatskaya A, Kennedy J, McLachlan IG, Heiman MG, Blacque OE, Sengupta P
Developmental cell 2016 Sep 12;38(5):493-506
Developmental cell 2016 Sep 12;38(5):493-506
Zfp423 Regulates Sonic Hedgehog Signaling via Primary Cilium Function.
Hong CJ, Hamilton BA
PLoS genetics 2016 Oct;12(10):e1006357
PLoS genetics 2016 Oct;12(10):e1006357
The serologically defined colon cancer antigen-3 (SDCCAG3) is involved in the regulation of ciliogenesis.
Yu F, Sharma S, Skowronek A, Erdmann KS
Scientific reports 2016 Oct 21;6:35399
Scientific reports 2016 Oct 21;6:35399
Defective ciliogenesis in thyroid hürthle cell tumors is associated with increased autophagy.
Lee J, Yi S, Kang YE, Chang JY, Kim JT, Sul HJ, Kim JO, Kim JM, Kim J, Porcelli AM, Kim KS, Shong M
Oncotarget 2016 Nov 29;7(48):79117-79130
Oncotarget 2016 Nov 29;7(48):79117-79130
Role for the IFT-A Complex in Selective Transport to the Primary Cilium.
Fu W, Wang L, Kim S, Li J, Dynlacht BD
Cell reports 2016 Nov 1;17(6):1505-1517
Cell reports 2016 Nov 1;17(6):1505-1517
Tethering of an E3 ligase by PCM1 regulates the abundance of centrosomal KIAA0586/Talpid3 and promotes ciliogenesis.
Wang L, Lee K, Malonis R, Sanchez I, Dynlacht BD
eLife 2016 May 5;5
eLife 2016 May 5;5
Tumor Suppressor Folliculin Regulates mTORC1 through Primary Cilia.
Zhong M, Zhao X, Li J, Yuan W, Yan G, Tong M, Guo S, Zhu Y, Jiang Y, Liu Y, Jiang Y
The Journal of biological chemistry 2016 May 27;291(22):11689-97
The Journal of biological chemistry 2016 May 27;291(22):11689-97
Overall Architecture of the Intraflagellar Transport (IFT)-B Complex Containing Cluap1/IFT38 as an Essential Component of the IFT-B Peripheral Subcomplex.
Katoh Y, Terada M, Nishijima Y, Takei R, Nozaki S, Hamada H, Nakayama K
The Journal of biological chemistry 2016 May 20;291(21):10962-75
The Journal of biological chemistry 2016 May 20;291(21):10962-75
Identification of drugs that restore primary cilium expression in cancer cells.
Khan NA, Willemarck N, Talebi A, Marchand A, Binda MM, Dehairs J, Rueda-Rincon N, Daniels VW, Bagadi M, Thimiri Govinda Raj DB, Vanderhoydonc F, Munck S, Chaltin P, Swinnen JV
Oncotarget 2016 Mar 1;7(9):9975-92
Oncotarget 2016 Mar 1;7(9):9975-92
Genome-wide screen identifies novel machineries required for both ciliogenesis and cell cycle arrest upon serum starvation.
Kim JH, Ki SM, Joung JG, Scott E, Heynen-Genel S, Aza-Blanc P, Kwon CH, Kim J, Gleeson JG, Lee JE
Biochimica et biophysica acta 2016 Jun;1863(6 Pt A):1307-18
Biochimica et biophysica acta 2016 Jun;1863(6 Pt A):1307-18
MicroRNA-548a-5p promotes proliferation and inhibits apoptosis in hepatocellular carcinoma cells by targeting Tg737.
Zhao G, Wang T, Huang QK, Pu M, Sun W, Zhang ZC, Ling R, Tao KS
World journal of gastroenterology 2016 Jun 21;22(23):5364-73
World journal of gastroenterology 2016 Jun 21;22(23):5364-73
The Interaction of Myc with Miz1 Defines Medulloblastoma Subgroup Identity.
Vo BT, Wolf E, Kawauchi D, Gebhardt A, Rehg JE, Finkelstein D, Walz S, Murphy BL, Youn YH, Han YG, Eilers M, Roussel MF
Cancer cell 2016 Jan 11;29(1):5-16
Cancer cell 2016 Jan 11;29(1):5-16
Biological and Chemical Removal of Primary Cilia Affects Mechanical Activation of Chondrogenesis Markers in Chondroprogenitors and Hypertrophic Chondrocytes.
Deren ME, Yang X, Guan Y, Chen Q
International journal of molecular sciences 2016 Feb 4;17(2):188
International journal of molecular sciences 2016 Feb 4;17(2):188
Phosphatidylinositol phosphate kinase PIPKIγ and phosphatase INPP5E coordinate initiation of ciliogenesis.
Xu Q, Zhang Y, Wei Q, Huang Y, Hu J, Ling K
Nature communications 2016 Feb 26;7:10777
Nature communications 2016 Feb 26;7:10777
Novel role for the midbody in primary ciliogenesis by polarized epithelial cells.
Bernabé-Rubio M, Andrés G, Casares-Arias J, Fernández-Barrera J, Rangel L, Reglero-Real N, Gershlick DC, Fernández JJ, Millán J, Correas I, Miguez DG, Alonso MA
The Journal of cell biology 2016 Aug 1;214(3):259-73
The Journal of cell biology 2016 Aug 1;214(3):259-73
Mutations in human C2CD3 cause skeletal dysplasia and provide new insights into phenotypic and cellular consequences of altered C2CD3 function.
Cortés CR, McInerney-Leo AM, Vogel I, Rondón Galeano MC, Leo PJ, Harris JE, Anderson LK, Keith PA, Brown MA, Ramsing M, Duncan EL, Zankl A, Wicking C
Scientific reports 2016 Apr 20;6:24083
Scientific reports 2016 Apr 20;6:24083
Tctex1d2 associates with short-rib polydactyly syndrome proteins and is required for ciliogenesis.
Gholkar AA, Senese S, Lo YC, Capri J, Deardorff WJ, Dharmarajan H, Contreras E, Hodara E, Whitelegge JP, Jackson PK, Torres JZ
Cell cycle (Georgetown, Tex.) 2015;14(7):1116-25
Cell cycle (Georgetown, Tex.) 2015;14(7):1116-25
Chibby functions to preserve normal ciliary morphology through the regulation of intraflagellar transport in airway ciliated cells.
Siller SS, Burke MC, Li FQ, Takemaru K
Cell cycle (Georgetown, Tex.) 2015;14(19):3163-72
Cell cycle (Georgetown, Tex.) 2015;14(19):3163-72
Imaging centrosomes and cilia in the mouse kidney.
Hoshi M, Wang J, Jain S, Mahjoub MR
Methods in cell biology 2015;127:1-17
Methods in cell biology 2015;127:1-17
Characterization of tetratricopeptide repeat-containing proteins critical for cilia formation and function.
Xu Y, Cao J, Huang S, Feng D, Zhang W, Zhu X, Yan X
PloS one 2015;10(4):e0124378
PloS one 2015;10(4):e0124378
A Cilia Independent Role of Ift88/Polaris during Cell Migration.
Boehlke C, Janusch H, Hamann C, Powelske C, Mergen M, Herbst H, Kotsis F, Nitschke R, Kuehn EW
PloS one 2015;10(10):e0140378
PloS one 2015;10(10):e0140378
Identification of a novel MKS locus defined by TMEM107 mutation.
Shaheen R, Almoisheer A, Faqeih E, Babay Z, Monies D, Tassan N, Abouelhoda M, Kurdi W, Al Mardawi E, Khalil MM, Seidahmed MZ, Alnemer M, Alsahan N, Sogaty S, Alhashem A, Singh A, Goyal M, Kapoor S, Alomar R, Ibrahim N, Alkuraya FS
Human molecular genetics 2015 Sep 15;24(18):5211-8
Human molecular genetics 2015 Sep 15;24(18):5211-8
Superresolution Pattern Recognition Reveals the Architectural Map of the Ciliary Transition Zone.
Yang TT, Su J, Wang WJ, Craige B, Witman GB, Tsou MF, Liao JC
Scientific reports 2015 Sep 14;5:14096
Scientific reports 2015 Sep 14;5:14096
Proteomics of Primary Cilia by Proximity Labeling.
Mick DU, Rodrigues RB, Leib RD, Adams CM, Chien AS, Gygi SP, Nachury MV
Developmental cell 2015 Nov 23;35(4):497-512
Developmental cell 2015 Nov 23;35(4):497-512
Myosin heavy chain 10 (MYH10) is required for centriole migration during the biogenesis of primary cilia.
Hong H, Kim J, Kim J
Biochemical and biophysical research communications 2015 May 22;461(1):180-5
Biochemical and biophysical research communications 2015 May 22;461(1):180-5
BIX-01294-induced autophagy regulates elongation of primary cilia.
Shin JH, Kim PS, Kim ES, Park SJ, Jo YK, Hwang JJ, Park TJ, Chang JW, Seo JH, Cho DH
Biochemical and biophysical research communications 2015 May 1;460(2):428-33
Biochemical and biophysical research communications 2015 May 1;460(2):428-33
The kinetochore protein, CENPF, is mutated in human ciliopathy and microcephaly phenotypes.
Waters AM, Asfahani R, Carroll P, Bicknell L, Lescai F, Bright A, Chanudet E, Brooks A, Christou-Savina S, Osman G, Walsh P, Bacchelli C, Chapgier A, Vernay B, Bader DM, Deshpande C, O' Sullivan M, Ocaka L, Stanescu H, Stewart HS, Hildebrandt F, Otto E, Johnson CA, Szymanska K, Katsanis N, Davis E, Kleta R, Hubank M, Doxsey S, Jackson A, Stupka E, Winey M, Beales PL
Journal of medical genetics 2015 Mar;52(3):147-56
Journal of medical genetics 2015 Mar;52(3):147-56
Centrin2 regulates CP110 removal in primary cilium formation.
Prosser SL, Morrison CG
The Journal of cell biology 2015 Mar 16;208(6):693-701
The Journal of cell biology 2015 Mar 16;208(6):693-701
A founder CEP120 mutation in Jeune asphyxiating thoracic dystrophy expands the role of centriolar proteins in skeletal ciliopathies.
Shaheen R, Schmidts M, Faqeih E, Hashem A, Lausch E, Holder I, Superti-Furga A, UK10K Consortium., Mitchison HM, Almoisheer A, Alamro R, Alshiddi T, Alzahrani F, Beales PL, Alkuraya FS
Human molecular genetics 2015 Mar 1;24(5):1410-9
Human molecular genetics 2015 Mar 1;24(5):1410-9
Adipogenic Differentiation of hMSCs is Mediated by Recruitment of IGF-1r Onto the Primary Cilium Associated With Cilia Elongation.
Dalbay MT, Thorpe SD, Connelly JT, Chapple JP, Knight MM
Stem cells (Dayton, Ohio) 2015 Jun;33(6):1952-61
Stem cells (Dayton, Ohio) 2015 Jun;33(6):1952-61
TCTEX1D2 mutations underlie Jeune asphyxiating thoracic dystrophy with impaired retrograde intraflagellar transport.
Schmidts M, Hou Y, Cortés CR, Mans DA, Huber C, Boldt K, Patel M, van Reeuwijk J, Plaza JM, van Beersum SE, Yap ZM, Letteboer SJ, Taylor SP, Herridge W, Johnson CA, Scambler PJ, Ueffing M, Kayserili H, Krakow D, King SM, UK10K., Beales PL, Al-Gazali L, Wicking C, Cormier-Daire V, Roepman R, Mitchison HM, Witman GB
Nature communications 2015 Jun 5;6:7074
Nature communications 2015 Jun 5;6:7074
Cell biology. Reversible centriole depletion with an inhibitor of Polo-like kinase 4.
Wong YL, Anzola JV, Davis RL, Yoon M, Motamedi A, Kroll A, Seo CP, Hsia JE, Kim SK, Mitchell JW, Mitchell BJ, Desai A, Gahman TC, Shiau AK, Oegema K
Science (New York, N.Y.) 2015 Jun 5;348(6239):1155-60
Science (New York, N.Y.) 2015 Jun 5;348(6239):1155-60
Mutations in DYNC2LI1 disrupt cilia function and cause short rib polydactyly syndrome.
Taylor SP, Dantas TJ, Duran I, Wu S, Lachman RS, University of Washington Center for Mendelian Genomics Consortium., Nelson SF, Cohn DH, Vallee RB, Krakow D
Nature communications 2015 Jun 16;6:7092
Nature communications 2015 Jun 16;6:7092
The MAL protein is crucial for proper membrane condensation at the ciliary base, which is required for primary cilium elongation.
Reales E, Bernabé-Rubio M, Casares-Arias J, Rentero C, Fernández-Barrera J, Rangel L, Correas I, Enrich C, Andrés G, Alonso MA
Journal of cell science 2015 Jun 15;128(12):2261-70
Journal of cell science 2015 Jun 15;128(12):2261-70
Leptin Elongates Hypothalamic Neuronal Cilia via Transcriptional Regulation and Actin Destabilization.
Kang GM, Han YM, Ko HW, Kim J, Oh BC, Kwon I, Kim MS
The Journal of biological chemistry 2015 Jul 17;290(29):18146-18155
The Journal of biological chemistry 2015 Jul 17;290(29):18146-18155
Specific variants in WDR35 cause a distinctive form of Ellis-van Creveld syndrome by disrupting the recruitment of the EvC complex and SMO into the cilium.
Caparrós-Martín JA, De Luca A, Cartault F, Aglan M, Temtamy S, Otaify GA, Mehrez M, Valencia M, Vázquez L, Alessandri JL, Nevado J, Rueda-Arenas I, Heath KE, Digilio MC, Dallapiccola B, Goodship JA, Mill P, Lapunzina P, Ruiz-Perez VL
Human molecular genetics 2015 Jul 15;24(14):4126-37
Human molecular genetics 2015 Jul 15;24(14):4126-37
DYNC2LI1 mutations broaden the clinical spectrum of dynein-2 defects.
Kessler K, Wunderlich I, Uebe S, Falk NS, Gießl A, Brandstätter JH, Popp B, Klinger P, Ekici AB, Sticht H, Dörr HG, Reis A, Roepman R, Seemanová E, Thiel CT
Scientific reports 2015 Jul 1;5:11649
Scientific reports 2015 Jul 1;5:11649
DCDC2 mutations cause a renal-hepatic ciliopathy by disrupting Wnt signaling.
Schueler M, Braun DA, Chandrasekar G, Gee HY, Klasson TD, Halbritter J, Bieder A, Porath JD, Airik R, Zhou W, LoTurco JJ, Che A, Otto EA, Böckenhauer D, Sebire NJ, Honzik T, Harris PC, Koon SJ, Gunay-Aygun M, Saunier S, Zerres K, Bruechle NO, Drenth JP, Pelletier L, Tapia-Páez I, Lifton RP, Giles RH, Kere J, Hildebrandt F
American journal of human genetics 2015 Jan 8;96(1):81-92
American journal of human genetics 2015 Jan 8;96(1):81-92
Lineage specificity of primary cilia in the mouse embryo.
Bangs FK, Schrode N, Hadjantonakis AK, Anderson KV
Nature cell biology 2015 Feb;17(2):113-22
Nature cell biology 2015 Feb;17(2):113-22
Deacetylation of α-tubulin and cortactin is required for HDAC6 to trigger ciliary disassembly.
Ran J, Yang Y, Li D, Liu M, Zhou J
Scientific reports 2015 Aug 6;5:12917
Scientific reports 2015 Aug 6;5:12917
Nek2 activation of Kif24 ensures cilium disassembly during the cell cycle.
Kim S, Lee K, Choi JH, Ringstad N, Dynlacht BD
Nature communications 2015 Aug 20;6:8087
Nature communications 2015 Aug 20;6:8087
GSK3β-Dzip1-Rab8 cascade regulates ciliogenesis after mitosis.
Zhang B, Zhang T, Wang G, Wang G, Chi W, Jiang Q, Zhang C
PLoS biology 2015 Apr;13(4):e1002129
PLoS biology 2015 Apr;13(4):e1002129
An in vivo chemical genetic screen identifies phosphodiesterase 4 as a pharmacological target for hedgehog signaling inhibition.
Williams CH, Hempel JE, Hao J, Frist AY, Williams MM, Fleming JT, Sulikowski GA, Cooper MK, Chiang C, Hong CC
Cell reports 2015 Apr 7;11(1):43-50
Cell reports 2015 Apr 7;11(1):43-50
Reciprocal regulation of cilia and autophagy via the MTOR and proteasome pathways.
Wang S, Livingston MJ, Su Y, Dong Z
Autophagy 2015 Apr 3;11(4):607-16
Autophagy 2015 Apr 3;11(4):607-16
Nephrocystin proteins NPHP5 and Cep290 regulate BBSome integrity, ciliary trafficking and cargo delivery.
Barbelanne M, Hossain D, Chan DP, Peränen J, Tsang WY
Human molecular genetics 2015 Apr 15;24(8):2185-200
Human molecular genetics 2015 Apr 15;24(8):2185-200
Ciliary abnormalities in senescent human fibroblasts impair proliferative capacity.
Breslin L, Prosser SL, Cuffe S, Morrison CG
Cell cycle (Georgetown, Tex.) 2014;13(17):2773-9
Cell cycle (Georgetown, Tex.) 2014;13(17):2773-9
Primary cilia signaling mediates intraocular pressure sensation.
Luo N, Conwell MD, Chen X, Kettenhofen CI, Westlake CJ, Cantor LB, Wells CD, Weinreb RN, Corson TW, Spandau DF, Joos KM, Iomini C, Obukhov AG, Sun Y
Proceedings of the National Academy of Sciences of the United States of America 2014 Sep 2;111(35):12871-6
Proceedings of the National Academy of Sciences of the United States of America 2014 Sep 2;111(35):12871-6
Nedd9 restrains renal cystogenesis in Pkd1-/- mice.
Nikonova AS, Plotnikova OV, Serzhanova V, Efimov A, Bogush I, Cai KQ, Hensley HH, Egleston BL, Klein-Szanto A, Seeger-Nukpezah T, Golemis EA
Proceedings of the National Academy of Sciences of the United States of America 2014 Sep 2;111(35):12859-64
Proceedings of the National Academy of Sciences of the United States of America 2014 Sep 2;111(35):12859-64
Basal foot MTOC organizes pillar MTs required for coordination of beating cilia.
Clare DK, Magescas J, Piolot T, Dumoux M, Vesque C, Pichard E, Dang T, Duvauchelle B, Poirier F, Delacour D
Nature communications 2014 Sep 12;5:4888
Nature communications 2014 Sep 12;5:4888
Crystal structures of IFT70/52 and IFT52/46 provide insight into intraflagellar transport B core complex assembly.
Taschner M, Kotsis F, Braeuer P, Kuehn EW, Lorentzen E
The Journal of cell biology 2014 Oct 27;207(2):269-82
The Journal of cell biology 2014 Oct 27;207(2):269-82
Disruption of the retinitis pigmentosa 28 gene Fam161a in mice affects photoreceptor ciliary structure and leads to progressive retinal degeneration.
Karlstetter M, Sorusch N, Caramoy A, Dannhausen K, Aslanidis A, Fauser S, Boesl MR, Nagel-Wolfrum K, Tamm ER, Jägle H, Stoehr H, Wolfrum U, Langmann T
Human molecular genetics 2014 Oct 1;23(19):5197-210
Human molecular genetics 2014 Oct 1;23(19):5197-210
CYLD mediates ciliogenesis in multiple organs by deubiquitinating Cep70 and inactivating HDAC6.
Yang Y, Ran J, Liu M, Li D, Li Y, Shi X, Meng D, Pan J, Ou G, Aneja R, Sun SC, Zhou J
Cell research 2014 Nov;24(11):1342-53
Cell research 2014 Nov;24(11):1342-53
The intraflagellar transport protein IFT27 promotes BBSome exit from cilia through the GTPase ARL6/BBS3.
Liew GM, Ye F, Nager AR, Murphy JP, Lee JS, Aguiar M, Breslow DK, Gygi SP, Nachury MV
Developmental cell 2014 Nov 10;31(3):265-278
Developmental cell 2014 Nov 10;31(3):265-278
Detection of primary cilia in human glioblastoma.
Sarkisian MR, Siebzehnrubl D, Hoang-Minh L, Deleyrolle L, Silver DJ, Siebzehnrubl FA, Guadiana SM, Srivinasan G, Semple-Rowland S, Harrison JK, Steindler DA, Reynolds BA
Journal of neuro-oncology 2014 Mar;117(1):15-24
Journal of neuro-oncology 2014 Mar;117(1):15-24
Primary cilia control hedgehog signaling during muscle differentiation and are deregulated in rhabdomyosarcoma.
Fu W, Asp P, Canter B, Dynlacht BD
Proceedings of the National Academy of Sciences of the United States of America 2014 Jun 24;111(25):9151-6
Proceedings of the National Academy of Sciences of the United States of America 2014 Jun 24;111(25):9151-6
ICK is essential for cell type-specific ciliogenesis and the regulation of ciliary transport.
Chaya T, Omori Y, Kuwahara R, Furukawa T
The EMBO journal 2014 Jun 2;33(11):1227-42
The EMBO journal 2014 Jun 2;33(11):1227-42
The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment.
He M, Subramanian R, Bangs F, Omelchenko T, Liem KF Jr, Kapoor TM, Anderson KV
Nature cell biology 2014 Jul;16(7):663-72
Nature cell biology 2014 Jul;16(7):663-72
Deletion of airway cilia results in noninflammatory bronchiectasis and hyperreactive airways.
Gilley SK, Stenbit AE, Pasek RC, Sas KM, Steele SL, Amria M, Bunni MA, Estell KP, Schwiebert LM, Flume P, Gooz M, Haycraft CJ, Yoder BK, Miller C, Pavlik JA, Turner GA, Sisson JH, Bell PD
American journal of physiology. Lung cellular and molecular physiology 2014 Jan;306(2):L162-9
American journal of physiology. Lung cellular and molecular physiology 2014 Jan;306(2):L162-9
Apical abscission alters cell polarity and dismantles the primary cilium during neurogenesis.
Das RM, Storey KG
Science (New York, N.Y.) 2014 Jan 10;343(6167):200-4
Science (New York, N.Y.) 2014 Jan 10;343(6167):200-4
Mutations in PLK4, encoding a master regulator of centriole biogenesis, cause microcephaly, growth failure and retinopathy.
Martin CA, Ahmad I, Klingseisen A, Hussain MS, Bicknell LS, Leitch A, Nürnberg G, Toliat MR, Murray JE, Hunt D, Khan F, Ali Z, Tinschert S, Ding J, Keith C, Harley ME, Heyn P, Müller R, Hoffmann I, Cormier-Daire V, Dollfus H, Dupuis L, Bashamboo A, McElreavey K, Kariminejad A, Mendoza-Londono R, Moore AT, Saggar A, Schlechter C, Weleber R, Thiele H, Altmüller J, Höhne W, Hurles ME, Noegel AA, Baig SM, Nürnberg P, Jackson AP
Nature genetics 2014 Dec;46(12):1283-1292
Nature genetics 2014 Dec;46(12):1283-1292
Katanin p80 regulates human cortical development by limiting centriole and cilia number.
Hu WF, Pomp O, Ben-Omran T, Kodani A, Henke K, Mochida GH, Yu TW, Woodworth MB, Bonnard C, Raj GS, Tan TT, Hamamy H, Masri A, Shboul M, Al Saffar M, Partlow JN, Al-Dosari M, Alazami A, Alowain M, Alkuraya FS, Reiter JF, Harris MP, Reversade B, Walsh CA
Neuron 2014 Dec 17;84(6):1240-57
Neuron 2014 Dec 17;84(6):1240-57
Active transport and diffusion barriers restrict Joubert Syndrome-associated ARL13B/ARL-13 to an Inv-like ciliary membrane subdomain.
Cevik S, Sanders AA, Van Wijk E, Boldt K, Clarke L, van Reeuwijk J, Hori Y, Horn N, Hetterschijt L, Wdowicz A, Mullins A, Kida K, Kaplan OI, van Beersum SE, Man Wu K, Letteboer SJ, Mans DA, Katada T, Kontani K, Ueffing M, Roepman R, Kremer H, Blacque OE
PLoS genetics 2013;9(12):e1003977
PLoS genetics 2013;9(12):e1003977
Acute versus chronic loss of mammalian Azi1/Cep131 results in distinct ciliary phenotypes.
Hall EA, Keighren M, Ford MJ, Davey T, Jarman AP, Smith LB, Jackson IJ, Mill P
PLoS genetics 2013;9(12):e1003928
PLoS genetics 2013;9(12):e1003928
Calcium-binding capacity of centrin2 is required for linear POC5 assembly but not for nucleotide excision repair.
Dantas TJ, Daly OM, Conroy PC, Tomas M, Wang Y, Lalor P, Dockery P, Ferrando-May E, Morrison CG
PloS one 2013;8(7):e68487
PloS one 2013;8(7):e68487
Transition fibre protein FBF1 is required for the ciliary entry of assembled intraflagellar transport complexes.
Wei Q, Xu Q, Zhang Y, Li Y, Zhang Q, Hu Z, Harris PC, Torres VE, Ling K, Hu J
Nature communications 2013;4:2750
Nature communications 2013;4:2750
Short-rib polydactyly and Jeune syndromes are caused by mutations in WDR60.
McInerney-Leo AM, Schmidts M, Cortés CR, Leo PJ, Gener B, Courtney AD, Gardiner B, Harris JA, Lu Y, Marshall M, UK10K Consortium., Scambler PJ, Beales PL, Brown MA, Zankl A, Mitchison HM, Duncan EL, Wicking C
American journal of human genetics 2013 Sep 5;93(3):515-23
American journal of human genetics 2013 Sep 5;93(3):515-23
Subretinal gene therapy of mice with Bardet-Biedl syndrome type 1.
Seo S, Mullins RF, Dumitrescu AV, Bhattarai S, Gratie D, Wang K, Stone EM, Sheffield V, Drack AV
Investigative ophthalmology & visual science 2013 Sep 11;54(9):6118-32
Investigative ophthalmology & visual science 2013 Sep 11;54(9):6118-32
ERK-mediated suppression of cilia in cisplatin-induced tubular cell apoptosis and acute kidney injury.
Wang S, Wei Q, Dong G, Dong Z
Biochimica et biophysica acta 2013 Oct;1832(10):1582-90
Biochimica et biophysica acta 2013 Oct;1832(10):1582-90
Functional interaction between autophagy and ciliogenesis.
Pampliega O, Orhon I, Patel B, Sridhar S, Díaz-Carretero A, Beau I, Codogno P, Satir BH, Satir P, Cuervo AM
Nature 2013 Oct 10;502(7470):194-200
Nature 2013 Oct 10;502(7470):194-200
Genetically encoded calcium indicator illuminates calcium dynamics in primary cilia.
Su S, Phua SC, DeRose R, Chiba S, Narita K, Kalugin PN, Katada T, Kontani K, Takeda S, Inoue T
Nature methods 2013 Nov;10(11):1105-7
Nature methods 2013 Nov;10(11):1105-7
Mutations in the gene encoding IFT dynein complex component WDR34 cause Jeune asphyxiating thoracic dystrophy.
Schmidts M, Vodopiutz J, Christou-Savina S, Cortés CR, McInerney-Leo AM, Emes RD, Arts HH, Tüysüz B, D'Silva J, Leo PJ, Giles TC, Oud MM, Harris JA, Koopmans M, Marshall M, Elçioglu N, Kuechler A, Bockenhauer D, Moore AT, Wilson LC, Janecke AR, Hurles ME, Emmet W, Gardiner B, Streubel B, Dopita B, Zankl A, Kayserili H, Scambler PJ, Brown MA, Beales PL, Wicking C, UK10K., Duncan EL, Mitchison HM
American journal of human genetics 2013 Nov 7;93(5):932-44
American journal of human genetics 2013 Nov 7;93(5):932-44
Exome sequencing identifies DYNC2H1 mutations as a common cause of asphyxiating thoracic dystrophy (Jeune syndrome) without major polydactyly, renal or retinal involvement.
Schmidts M, Arts HH, Bongers EM, Yap Z, Oud MM, Antony D, Duijkers L, Emes RD, Stalker J, Yntema JB, Plagnol V, Hoischen A, Gilissen C, Forsythe E, Lausch E, Veltman JA, Roeleveld N, Superti-Furga A, Kutkowska-Kazmierczak A, Kamsteeg EJ, Elçioğlu N, van Maarle MC, Graul-Neumann LM, Devriendt K, Smithson SF, Wellesley D, Verbeek NE, Hennekam RC, Kayserili H, Scambler PJ, Beales PL, UK10K., Knoers NV, Roepman R, Mitchison HM
Journal of medical genetics 2013 May;50(5):309-23
Journal of medical genetics 2013 May;50(5):309-23
Visualizing renal primary cilia.
Deane JA, Verghese E, Martelotto LG, Cain JE, Galtseva A, Rosenblum ND, Watkins DN, Ricardo SD
Nephrology (Carlton, Vic.) 2013 Mar;18(3):161-8
Nephrology (Carlton, Vic.) 2013 Mar;18(3):161-8
Rer1p maintains ciliary length and signaling by regulating γ-secretase activity and Foxj1a levels.
Jurisch-Yaksi N, Rose AJ, Lu H, Raemaekers T, Munck S, Baatsen P, Baert V, Vermeire W, Scales SJ, Verleyen D, Vandepoel R, Tylzanowski P, Yaksi E, de Ravel T, Yost HJ, Froyen G, Arrington CB, Annaert W
The Journal of cell biology 2013 Mar 18;200(6):709-20
The Journal of cell biology 2013 Mar 18;200(6):709-20
CEP162 is an axoneme-recognition protein promoting ciliary transition zone assembly at the cilia base.
Wang WJ, Tay HG, Soni R, Perumal GS, Goll MG, Macaluso FP, Asara JM, Amack JD, Tsou MF
Nature cell biology 2013 Jun;15(6):591-601
Nature cell biology 2013 Jun;15(6):591-601
Pathogenic NPHP5 mutations impair protein interaction with Cep290, a prerequisite for ciliogenesis.
Barbelanne M, Song J, Ahmadzai M, Tsang WY
Human molecular genetics 2013 Jun 15;22(12):2482-94
Human molecular genetics 2013 Jun 15;22(12):2482-94
Superresolution STED microscopy reveals differential localization in primary cilia.
Yang TT, Hampilos PJ, Nathwani B, Miller CH, Sutaria ND, Liao JC
Cytoskeleton (Hoboken, N.J.) 2013 Jan;70(1):54-65
Cytoskeleton (Hoboken, N.J.) 2013 Jan;70(1):54-65
The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling.
Mukhopadhyay S, Wen X, Ratti N, Loktev A, Rangell L, Scales SJ, Jackson PK
Cell 2013 Jan 17;152(1-2):210-23
Cell 2013 Jan 17;152(1-2):210-23
Centriole distal appendages promote membrane docking, leading to cilia initiation.
Tanos BE, Yang HJ, Soni R, Wang WJ, Macaluso FP, Asara JM, Tsou MF
Genes & development 2013 Jan 15;27(2):163-8
Genes & development 2013 Jan 15;27(2):163-8
Kif3a interacts with Dynactin subunit p150 Glued to organize centriole subdistal appendages.
Kodani A, Salomé Sirerol-Piquer M, Seol A, Garcia-Verdugo JM, Reiter JF
The EMBO journal 2013 Feb 20;32(4):597-607
The EMBO journal 2013 Feb 20;32(4):597-607
CCRK depletion inhibits glioblastoma cell proliferation in a cilium-dependent manner.
Yang Y, Roine N, Mäkelä TP
EMBO reports 2013 Aug;14(8):741-7
EMBO reports 2013 Aug;14(8):741-7
CCDC41 is required for ciliary vesicle docking to the mother centriole.
Joo K, Kim CG, Lee MS, Moon HY, Lee SH, Kim MJ, Kweon HS, Park WY, Kim CH, Gleeson JG, Kim J
Proceedings of the National Academy of Sciences of the United States of America 2013 Apr 9;110(15):5987-92
Proceedings of the National Academy of Sciences of the United States of America 2013 Apr 9;110(15):5987-92
HDAC6 inhibition restores ciliary expression and decreases tumor growth.
Gradilone SA, Radtke BN, Bogert PS, Huang BQ, Gajdos GB, LaRusso NF
Cancer research 2013 Apr 1;73(7):2259-70
Cancer research 2013 Apr 1;73(7):2259-70
The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis.
Goetz SC, Liem KF Jr, Anderson KV
Cell 2012 Nov 9;151(4):847-858
Cell 2012 Nov 9;151(4):847-858
BBS proteins interact genetically with the IFT pathway to influence SHH-related phenotypes.
Zhang Q, Seo S, Bugge K, Stone EM, Sheffield VC
Human molecular genetics 2012 May 1;21(9):1945-53
Human molecular genetics 2012 May 1;21(9):1945-53
Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein.
Firestone AJ, Weinger JS, Maldonado M, Barlan K, Langston LD, O'Donnell M, Gelfand VI, Kapoor TM, Chen JK
Nature 2012 Mar 18;484(7392):125-9
Nature 2012 Mar 18;484(7392):125-9
The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking.
Liem KF Jr, Ashe A, He M, Satir P, Moran J, Beier D, Wicking C, Anderson KV
The Journal of cell biology 2012 Jun 11;197(6):789-800
The Journal of cell biology 2012 Jun 11;197(6):789-800
A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened.
Seo S, Zhang Q, Bugge K, Breslow DK, Searby CC, Nachury MV, Sheffield VC
PLoS genetics 2011 Nov;7(11):e1002358
PLoS genetics 2011 Nov;7(11):e1002358
Complex interactions between genes controlling trafficking in primary cilia.
Ocbina PJ, Eggenschwiler JT, Moskowitz I, Anderson KV
Nature genetics 2011 Jun;43(6):547-53
Nature genetics 2011 Jun;43(6):547-53
A role for the primary cilium in Notch signaling and epidermal differentiation during skin development.
Ezratty EJ, Stokes N, Chai S, Shah AS, Williams SE, Fuchs E
Cell 2011 Jun 24;145(7):1129-41
Cell 2011 Jun 24;145(7):1129-41
Centriolar kinesin Kif24 interacts with CP110 to remodel microtubules and regulate ciliogenesis.
Kobayashi T, Tsang WY, Li J, Lane W, Dynlacht BD
Cell 2011 Jun 10;145(6):914-25
Cell 2011 Jun 10;145(6):914-25
A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition.
Garcia-Gonzalo FR, Corbit KC, Sirerol-Piquer MS, Ramaswami G, Otto EA, Noriega TR, Seol AD, Robinson JF, Bennett CL, Josifova DJ, García-Verdugo JM, Katsanis N, Hildebrandt F, Reiter JF
Nature genetics 2011 Jul 3;43(8):776-84
Nature genetics 2011 Jul 3;43(8):776-84
Disruption of a ciliary B9 protein complex causes Meckel syndrome.
Dowdle WE, Robinson JF, Kneist A, Sirerol-Piquer MS, Frints SG, Corbit KC, Zaghloul NA, van Lijnschoten G, Mulders L, Verver DE, Zerres K, Reed RR, Attié-Bitach T, Johnson CA, García-Verdugo JM, Katsanis N, Bergmann C, Reiter JF
American journal of human genetics 2011 Jul 15;89(1):94-110
American journal of human genetics 2011 Jul 15;89(1):94-110
The role of RPGR in cilia formation and actin stability.
Gakovic M, Shu X, Kasioulis I, Carpanini S, Moraga I, Wright AF
Human molecular genetics 2011 Dec 15;20(24):4840-50
Human molecular genetics 2011 Dec 15;20(24):4840-50
Functional characterization of putative cilia genes by high-content analysis.
Lai CK, Gupta N, Wen X, Rangell L, Chih B, Peterson AS, Bazan JF, Li L, Scales SJ
Molecular biology of the cell 2011 Apr;22(7):1104-19
Molecular biology of the cell 2011 Apr;22(7):1104-19
The cilia protein IFT88 is required for spindle orientation in mitosis.
Delaval B, Bright A, Lawson ND, Doxsey S
Nature cell biology 2011 Apr;13(4):461-8
Nature cell biology 2011 Apr;13(4):461-8
TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia.
Mukhopadhyay S, Wen X, Chih B, Nelson CD, Lane WS, Scales SJ, Jackson PK
Genes & development 2010 Oct 1;24(19):2180-93
Genes & development 2010 Oct 1;24(19):2180-93
Primary cilia regulate mTORC1 activity and cell size through Lkb1.
Boehlke C, Kotsis F, Patel V, Braeg S, Voelker H, Bredt S, Beyer T, Janusch H, Hamann C, Gödel M, Müller K, Herbst M, Hornung M, Doerken M, Köttgen M, Nitschke R, Igarashi P, Walz G, Kuehn EW
Nature cell biology 2010 Nov;12(11):1115-22
Nature cell biology 2010 Nov;12(11):1115-22
DISC1 regulates primary cilia that display specific dopamine receptors.
Marley A, von Zastrow M
PloS one 2010 May 28;5(5):e10902
PloS one 2010 May 28;5(5):e10902
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 13967-1-AP(IFT88 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human heart using 13967-1-AP(IFT88 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human heart using 13967-1-AP(IFT88 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue