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- Western blot [1]
- Immunohistochemistry [2]
- Flow cytometry [1]
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- Product number
- 20276-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#20276-1-AP, RRID:AB_10697657
- Product name
- LATS2-Specific antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated LATS2-Specific antibody (Cat. #20276-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The Hippo signaling component LATS2 enhances innate immunity to inhibit HIV-1 infection through PQBP1-cGAS pathway.
Tumor-derived exosomal miR-19b-3p facilitates M2 macrophage polarization and exosomal LINC00273 secretion to promote lung adenocarcinoma metastasis via Hippo pathway.
CYT387, a potent IKBKE inhibitor, suppresses human glioblastoma progression by activating the Hippo pathway.
Deficiency of large tumor suppressor kinase 1 causes congenital hearing loss associated with cochlear abnormalities in mice.
Schwannoma development is mediated by Hippo pathway dysregulation and modified by RAS/MAPK signaling.
Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis.
The Human Novel Gene LNC-HC Inhibits Hepatocellular Carcinoma Cell Proliferation by Sequestering hsa-miR-183-5p.
MicroRNA‑93 promotes angiogenesis and attenuates remodeling via inactivation of the Hippo/Yap pathway by targeting Lats2 after myocardial infarctionω.
Hippo pathway and tumoral FOXP3 expression correlate with tumor growth in squamous cell carcinoma of the lung.
TRIB3 confers radiotherapy resistance in esophageal squamous cell carcinoma by stabilizing TAZ.
miR-25 Promotes Cell Proliferation, Migration, and Invasion of Non-Small-Cell Lung Cancer by Targeting the LATS2/YAP Signaling Pathway.
Essential Oil from Pinus Koraiensis Pinecones Inhibits Gastric Cancer Cells via the HIPPO/YAP Signaling Pathway.
The CalcR-PKA-Yap1 Axis Is Critical for Maintaining Quiescence in Muscle Stem Cells.
CLDN6 promotes tumor progression through the YAP1-snail1 axis in gastric cancer.
Myricetin Suppresses the Propagation of Hepatocellular Carcinoma via Down-Regulating Expression of YAP.
YAP triggers the Wnt/β-catenin signalling pathway and promotes enterocyte self-renewal, regeneration and tumorigenesis after DSS-induced injury.
Large tumor suppressor 2, LATS2, activates JNK in a kinase-independent mechanism through ASK1.
A comprehensive evaluation of Hippo pathway silencing in sarcomas.
MicroRNA-31 activates the RAS pathway and functions as an oncogenic MicroRNA in human colorectal cancer by repressing RAS p21 GTPase activating protein 1 (RASA1).
He TS, Dang L, Zhang J, Zhang J, Wang G, Wang E, Xia H, Zhou W, Wu S, Liu X
Cell death and differentiation 2022 Jan;29(1):192-205
Cell death and differentiation 2022 Jan;29(1):192-205
Tumor-derived exosomal miR-19b-3p facilitates M2 macrophage polarization and exosomal LINC00273 secretion to promote lung adenocarcinoma metastasis via Hippo pathway.
Chen J, Zhang K, Zhi Y, Wu Y, Chen B, Bai J, Wang X
Clinical and translational medicine 2021 Sep;11(9):e478
Clinical and translational medicine 2021 Sep;11(9):e478
CYT387, a potent IKBKE inhibitor, suppresses human glioblastoma progression by activating the Hippo pathway.
Wang X, Lu J, Li J, Liu Y, Guo G, Huang Q
Journal of translational medicine 2021 Sep 20;19(1):396
Journal of translational medicine 2021 Sep 20;19(1):396
Deficiency of large tumor suppressor kinase 1 causes congenital hearing loss associated with cochlear abnormalities in mice.
Nishiyama T, Fujioka M, Saegusa C, Oishi N, Harada T, Hosoya M, Saya H, Ogawa K
Biochemical and biophysical research communications 2021 Jan 1;534:921-926
Biochemical and biophysical research communications 2021 Jan 1;534:921-926
Schwannoma development is mediated by Hippo pathway dysregulation and modified by RAS/MAPK signaling.
Chen Z, Li S, Mo J, Hawley E, Wang Y, He Y, Brosseau JP, Shipman T, Clapp DW, Carroll TJ, Le LQ
JCI insight 2020 Oct 15;5(20)
JCI insight 2020 Oct 15;5(20)
Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis.
Wang X, Cai B, Yang X, Sonubi OO, Zheng Z, Ramakrishnan R, Shi H, Valenti L, Pajvani UB, Sandhu J, Infante RE, Radhakrishnan A, Covey DF, Guan KL, Buck J, Levin LR, Tontonoz P, Schwabe RF, Tabas I
Cell metabolism 2020 May 5;31(5):969-986.e7
Cell metabolism 2020 May 5;31(5):969-986.e7
The Human Novel Gene LNC-HC Inhibits Hepatocellular Carcinoma Cell Proliferation by Sequestering hsa-miR-183-5p.
Lan X, Wu N, Wu L, Qu K, Osoro EK, Guan D, Du X, Wang B, Chen S, Miao J, Ren J, Liu L, Li H, Ning Q, Li D, Lu S
Molecular therapy. Nucleic acids 2020 Jun 5;20:468-479
Molecular therapy. Nucleic acids 2020 Jun 5;20:468-479
MicroRNA‑93 promotes angiogenesis and attenuates remodeling via inactivation of the Hippo/Yap pathway by targeting Lats2 after myocardial infarctionω.
Ma C, Peng P, Zhou Y, Liu T, Wang L, Lu C
Molecular medicine reports 2020 Jul;22(1):483-493
Molecular medicine reports 2020 Jul;22(1):483-493
Hippo pathway and tumoral FOXP3 expression correlate with tumor growth in squamous cell carcinoma of the lung.
Won KY, Kim HK, Kim GY, Song MJ, Lim SJ
Pathology, research and practice 2020 Jul;216(7):153003
Pathology, research and practice 2020 Jul;216(7):153003
TRIB3 confers radiotherapy resistance in esophageal squamous cell carcinoma by stabilizing TAZ.
Zhou S, Liu S, Lin C, Li Y, Ye L, Wu X, Jian Y, Dai Y, Ouyang Y, Zhao L, Liu M, Song L, Xi M
Oncogene 2020 Apr;39(18):3710-3725
Oncogene 2020 Apr;39(18):3710-3725
miR-25 Promotes Cell Proliferation, Migration, and Invasion of Non-Small-Cell Lung Cancer by Targeting the LATS2/YAP Signaling Pathway.
Wu T, Hu H, Zhang T, Jiang L, Li X, Liu S, Zheng C, Yan G, Chen W, Ning Y, Li Y, Lu Z
Oxidative medicine and cellular longevity 2019;2019:9719723
Oxidative medicine and cellular longevity 2019;2019:9719723
Essential Oil from Pinus Koraiensis Pinecones Inhibits Gastric Cancer Cells via the HIPPO/YAP Signaling Pathway.
Zhang Y, Xin C, Qiu J, Wang Z
Molecules (Basel, Switzerland) 2019 Oct 25;24(21)
Molecules (Basel, Switzerland) 2019 Oct 25;24(21)
The CalcR-PKA-Yap1 Axis Is Critical for Maintaining Quiescence in Muscle Stem Cells.
Zhang L, Noguchi YT, Nakayama H, Kaji T, Tsujikawa K, Ikemoto-Uezumi M, Uezumi A, Okada Y, Doi T, Watanabe S, Braun T, Fujio Y, Fukada SI
Cell reports 2019 Nov 19;29(8):2154-2163.e5
Cell reports 2019 Nov 19;29(8):2154-2163.e5
CLDN6 promotes tumor progression through the YAP1-snail1 axis in gastric cancer.
Yu S, Zhang Y, Li Q, Zhang Z, Zhao G, Xu J
Cell death & disease 2019 Dec 11;10(12):949
Cell death & disease 2019 Dec 11;10(12):949
Myricetin Suppresses the Propagation of Hepatocellular Carcinoma via Down-Regulating Expression of YAP.
Li M, Chen J, Yu X, Xu S, Li D, Zheng Q, Yin Y
Cells 2019 Apr 17;8(4)
Cells 2019 Apr 17;8(4)
YAP triggers the Wnt/β-catenin signalling pathway and promotes enterocyte self-renewal, regeneration and tumorigenesis after DSS-induced injury.
Deng F, Peng L, Li Z, Tan G, Liang E, Chen S, Zhao X, Zhi F
Cell death & disease 2018 Feb 2;9(2):153
Cell death & disease 2018 Feb 2;9(2):153
Large tumor suppressor 2, LATS2, activates JNK in a kinase-independent mechanism through ASK1.
Rusnak L, Tang C, Qi Q, Mo X, Fu H
Journal of molecular cell biology 2018 Dec 1;10(6):549-558
Journal of molecular cell biology 2018 Dec 1;10(6):549-558
A comprehensive evaluation of Hippo pathway silencing in sarcomas.
Merritt NM, Fullenkamp CA, Hall SL, Qian Q, Desai C, Thomason J, Lambertz AM, Dupuy AJ, Darbro B, Tanas MR
Oncotarget 2018 Aug 3;9(60):31620-31636
Oncotarget 2018 Aug 3;9(60):31620-31636
MicroRNA-31 activates the RAS pathway and functions as an oncogenic MicroRNA in human colorectal cancer by repressing RAS p21 GTPase activating protein 1 (RASA1).
Sun D, Yu F, Ma Y, Zhao R, Chen X, Zhu J, Zhang CY, Chen J, Zhang J
The Journal of biological chemistry 2013 Mar 29;288(13):9508-18
The Journal of biological chemistry 2013 Mar 29;288(13):9508-18
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- SGC-7901 cells were subjected to SDS PAGE followed by western blot with 20276-1-AP(LATS2-Specific antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human heart using 20276-1-AP(LATS2-Specific antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human heart using 20276-1-AP(LATS2-Specific antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The LATS2-Specific antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human LATS2-Specific. This antibody recognizes human antigen. The LATS2-Specific antibody has been validated for the following applications: ELISA, WB, IHC, FC analysis.
