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- Product number
- ABIN152335 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 1-50) antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Epitope
- AA 1-50
- Vial size
- 100 μL
- Storage
- Store at 4°C. Do not freeze.
- Handling
- Do not freeze.
Submitted references Biphasic Regulation of Yes-associated Protein (YAP) Cellular Localization, Phosphorylation, and Activity by G Protein-coupled Receptor Agonists in Intestinal Epithelial Cells: A NOVEL ROLE FOR PROTEIN KINASE D (PKD).
RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2.
Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype.
The Hippo pathway kinase Lats2 prevents DNA damage-induced apoptosis through inhibition of the tyrosine kinase c-Abl.
KIBRA regulates aurora kinase activity and is required for precise chromosome alignment during mitosis.
Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation.
An indirect role for ASPP1 in limiting p53-dependent p21 expression and cellular senescence.
Negative regulation of Yap during neuronal differentiation.
Angiomotin family proteins are novel activators of the LATS2 kinase tumor suppressor.
LATS2 is a tumor suppressor gene of malignant mesothelioma.
Increased inflammatory signaling and lethality of influenza H1N1 by nuclear thioredoxin-1.
A kinase shRNA screen links LATS2 and the pRB tumor suppressor.
Mammalian Ste20-like kinase (Mst2) indirectly supports Raf-1/ERK pathway activity via maintenance of protein phosphatase-2A catalytic subunit levels and consequent suppression of inhibitory Raf-1 phosphorylation.
Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver.
Wang J, Sinnett-Smith J, Stevens JV, Young SH, Rozengurt E
The Journal of biological chemistry 2016 Aug 19;291(34):17988-8005
The Journal of biological chemistry 2016 Aug 19;291(34):17988-8005
RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2.
Pefani DE, Latusek R, Pires I, Grawenda AM, Yee KS, Hamilton G, van der Weyden L, Esashi F, Hammond EM, O'Neill E
Nature cell biology 2014 Oct;16(10):962-71, 1-8
Nature cell biology 2014 Oct;16(10):962-71, 1-8
Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype.
Xiang L, Gilkes DM, Hu H, Takano N, Luo W, Lu H, Bullen JW, Samanta D, Liang H, Semenza GL
Oncotarget 2014 Dec 30;5(24):12509-27
Oncotarget 2014 Dec 30;5(24):12509-27
The Hippo pathway kinase Lats2 prevents DNA damage-induced apoptosis through inhibition of the tyrosine kinase c-Abl.
Reuven N, Adler J, Meltser V, Shaul Y
Cell death and differentiation 2013 Oct;20(10):1330-40
Cell death and differentiation 2013 Oct;20(10):1330-40
KIBRA regulates aurora kinase activity and is required for precise chromosome alignment during mitosis.
Zhang L, Iyer J, Chowdhury A, Ji M, Xiao L, Yang S, Chen Y, Tsai MY, Dong J
The Journal of biological chemistry 2012 Oct 5;287(41):34069-77
The Journal of biological chemistry 2012 Oct 5;287(41):34069-77
Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation.
Zhang K, Rodriguez-Aznar E, Yabuta N, Owen RJ, Mingot JM, Nojima H, Nieto MA, Longmore GD
The EMBO journal 2012 Jan 4;31(1):29-43
The EMBO journal 2012 Jan 4;31(1):29-43
An indirect role for ASPP1 in limiting p53-dependent p21 expression and cellular senescence.
Vigneron AM, Vousden KH
The EMBO journal 2012 Jan 18;31(2):471-80
The EMBO journal 2012 Jan 18;31(2):471-80
Negative regulation of Yap during neuronal differentiation.
Zhang H, Deo M, Thompson RC, Uhler MD, Turner DL
Developmental biology 2012 Jan 1;361(1):103-15
Developmental biology 2012 Jan 1;361(1):103-15
Angiomotin family proteins are novel activators of the LATS2 kinase tumor suppressor.
Paramasivam M, Sarkeshik A, Yates JR 3rd, Fernandes MJ, McCollum D
Molecular biology of the cell 2011 Oct;22(19):3725-33
Molecular biology of the cell 2011 Oct;22(19):3725-33
LATS2 is a tumor suppressor gene of malignant mesothelioma.
Murakami H, Mizuno T, Taniguchi T, Fujii M, Ishiguro F, Fukui T, Akatsuka S, Horio Y, Hida T, Kondo Y, Toyokuni S, Osada H, Sekido Y
Cancer research 2011 Feb 1;71(3):873-83
Cancer research 2011 Feb 1;71(3):873-83
Increased inflammatory signaling and lethality of influenza H1N1 by nuclear thioredoxin-1.
Go YM, Kang SM, Roede JR, Orr M, Jones DP
PloS one 2011 Apr 15;6(4):e18918
PloS one 2011 Apr 15;6(4):e18918
A kinase shRNA screen links LATS2 and the pRB tumor suppressor.
Tschöp K, Conery AR, Litovchick L, Decaprio JA, Settleman J, Harlow E, Dyson N
Genes & development 2011 Apr 15;25(8):814-30
Genes & development 2011 Apr 15;25(8):814-30
Mammalian Ste20-like kinase (Mst2) indirectly supports Raf-1/ERK pathway activity via maintenance of protein phosphatase-2A catalytic subunit levels and consequent suppression of inhibitory Raf-1 phosphorylation.
Kilili GK, Kyriakis JM
The Journal of biological chemistry 2010 May 14;285(20):15076-87
The Journal of biological chemistry 2010 May 14;285(20):15076-87
Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver.
Benhamouche S, Curto M, Saotome I, Gladden AB, Liu CH, Giovannini M, McClatchey AI
Genes & development 2010 Aug 15;24(16):1718-30
Genes & development 2010 Aug 15;24(16):1718-30
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- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
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