CABT-RM153

antibody from Creative Diagnostics

Targeting: CELF4 BRUNOL4

Western blot (Recommended by provider)

Antibody Data

Product number

CABT-RM153

Provider

Creative Diagnostics

Product name

Mouse Anti-CELF4 monoclonal antibody, clone O557/90

Antibody type

Monoclonal

Description

CUGBP Elav-like family member 4 is encoded by the CELF4 gene in human. CELF-4 is a RNA-binding protein that is implicated in the regulation of pre-mRNA alternative splicing. It is ubiquitous in its distribution, but is strongly expressed in the cerebellum, hippocampus, amygdala, temporal and frontal cortex, and frontal lobes. It mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. It is shown to specifically activate exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. CELF-4 is reported to promote exclusion of both the smooth muscle and non-muscle exons in actinin pre-mRNAs. It binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. The N-terminal region (aa 1-298) is considered to be sufficient for its RNA-binding and MSE-dependent splicing activity. CELF-4 contains contain two N-terminal RNA recognition motif (RRM) domains (aa 54-135 and 152-232) and one C-terminal RRM domain (aa 404-479). Five isoforms of CELF-4 have been described that are produced by alternative splicing.

Reactivity

Human, Mouse, Rat

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG