Antibody data
- Antibody Data
- Antigen structure
- References [10]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
- Flow cytometry [1]
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Validation data
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- Product number
- 15180-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15180-1-AP, RRID:AB_2065826
- Product name
- CA12 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CA12 antibody (Cat. #15180-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Matrine injection inhibits pancreatic cancer growth via modulating carbonic anhydrases- a network pharmacology-based study with in vitro validation.
Overexpressed CA12 has prognostic value in pancreatic cancer and promotes tumor cell apoptosis via NF-κB signaling.
Large pH oscillations promote host defense against human airways infection.
Drug Repurposing as an Antitumor Agent: Disulfiram-Mediated Carbonic Anhydrase 12 and Anion Exchanger 2 Modulation to Inhibit Cancer Cell Migration.
Carbonic anhydrase 12 mutation modulates membrane stability and volume regulation of aquaporin 5.
N-Cadherin Maintains the Healthy Biology of Nucleus Pulposus Cells under High-Magnitude Compression.
Governing effect of regulatory proteins for Cl(-)/HCO3(-) exchanger 2 activity.
Loss of carbonic anhydrase XII function in individuals with elevated sweat chloride concentration and pulmonary airway disease.
Mechanism of irradiation-induced mammary cancer metastasis: A role for SAP-dependent Mkl1 signaling.
Essential role of carbonic anhydrase XII in secretory gland fluid and HCO3 (-) secretion revealed by disease causing human mutation.
Xu PL, Cheng CS, Jiao JY, Chen H, Chen Z, Li P
Journal of ethnopharmacology 2021 Sep 29;287:114691
Journal of ethnopharmacology 2021 Sep 29;287:114691
Overexpressed CA12 has prognostic value in pancreatic cancer and promotes tumor cell apoptosis via NF-κB signaling.
Du Y, Xin Z, Liu T, Xu P, Mao F, Yao J
Journal of cancer research and clinical oncology 2021 May;147(5):1557-1564
Journal of cancer research and clinical oncology 2021 May;147(5):1557-1564
Large pH oscillations promote host defense against human airways infection.
Kim D, Liao J, Scales NB, Martini C, Luan X, Abu-Arish A, Robert R, Luo Y, McKay GA, Nguyen D, Tewfik MA, Poirier CD, Matouk E, Ianowski JP, Frenkiel S, Hanrahan JW
The Journal of experimental medicine 2021 Apr 5;218(4)
The Journal of experimental medicine 2021 Apr 5;218(4)
Drug Repurposing as an Antitumor Agent: Disulfiram-Mediated Carbonic Anhydrase 12 and Anion Exchanger 2 Modulation to Inhibit Cancer Cell Migration.
Hwang S, Shin DM, Hong JH
Molecules (Basel, Switzerland) 2019 Sep 19;24(18)
Molecules (Basel, Switzerland) 2019 Sep 19;24(18)
Carbonic anhydrase 12 mutation modulates membrane stability and volume regulation of aquaporin 5.
Hwang S, Kang JY, Kim MJ, Shin DM, Hong JH
Journal of enzyme inhibition and medicinal chemistry 2019 Dec;34(1):179-188
Journal of enzyme inhibition and medicinal chemistry 2019 Dec;34(1):179-188
N-Cadherin Maintains the Healthy Biology of Nucleus Pulposus Cells under High-Magnitude Compression.
Wang Z, Leng J, Zhao Y, Yu D, Xu F, Song Q, Qu Z, Zhuang X, Liu Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(6):2327-2337
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(6):2327-2337
Governing effect of regulatory proteins for Cl(-)/HCO3(-) exchanger 2 activity.
Jeong YS, Hong JH
Channels (Austin, Tex.) 2016;10(3):214-24
Channels (Austin, Tex.) 2016;10(3):214-24
Loss of carbonic anhydrase XII function in individuals with elevated sweat chloride concentration and pulmonary airway disease.
Lee M, Vecchio-Pagán B, Sharma N, Waheed A, Li X, Raraigh KS, Robbins S, Han ST, Franca AL, Pellicore MJ, Evans TA, Arcara KM, Nguyen H, Luan S, Belchis D, Hertecant J, Zabner J, Sly WS, Cutting GR
Human molecular genetics 2016 May 15;25(10):1923-1933
Human molecular genetics 2016 May 15;25(10):1923-1933
Mechanism of irradiation-induced mammary cancer metastasis: A role for SAP-dependent Mkl1 signaling.
Asparuhova MB, Secondini C, Rüegg C, Chiquet-Ehrismann R
Molecular oncology 2015 Oct;9(8):1510-27
Molecular oncology 2015 Oct;9(8):1510-27
Essential role of carbonic anhydrase XII in secretory gland fluid and HCO3 (-) secretion revealed by disease causing human mutation.
Hong JH, Muhammad E, Zheng C, Hershkovitz E, Alkrinawi S, Loewenthal N, Parvari R, Muallem S
The Journal of physiology 2015 Dec 15;593(24):5299-312
The Journal of physiology 2015 Dec 15;593(24):5299-312
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- BxPC-3 cells were subjected to SDS PAGE followed by western blot with 15180-1-AP(CA12 antibody) at dilution of 1:300
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 15180-1-AP(CA12 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 15180-1-AP(CA12 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The CA12 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CA12. This antibody recognizes human,mouse,rat antigen. The CA12 antibody has been validated for the following applications: ELISA, WB, IHC, FC analysis.