DCABH-8818

antibody from Creative Diagnostics

Targeting: CD74 DHLAG

Western blot (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Antibody Data

Product number

DCABH-8818

Provider

Creative Diagnostics

Proper citation

Creative Diagnostics Cat#DCABH-8818, RRID:AB_2481882

Product name

Rabbit Anti-APC monoclonal antibody, clone TD72-14

Antibody type

Monoclonal

Description

The adenomatous polyposis syndromes, familial adenomatous polyposis (FAP) and Gardner's syndrome (GS), are characterized by numerous adenomatous polyps throughout the entire colon. These polyps invariably progress to colon cancer in addition to other extracolonic manifestations. The cloning of the APC gene revealed a ubiquitously expressed protein, 2,843 amino acids in length, which is frequently mutated in patients suffering from FAP and GS. APC has been found to be associated with structural components of intracellular junctions. ÉÇ-catenin and ÎÛ-catenin (also called plakoglobin), are involved in the regulation of cellular adhesion. APC and E-cadherin compete for binding to specific internal regions of both ÉÇ- and ÎÛ-catenin. Interactions between cytoskeleton and the APC, E-cadherin, ÉÇ/ÎÛ catenin complex are mediated by Ï«-catenin.

Reactivity

Human, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

TD72-14

Vial size

100 _l

Storage

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.