Antibody data

Product number
36-3035 - Provider product page
Provider
ABEOMICS Inc.
Product name
Anti-CD74w Antibody
Antibody type
Monoclonal
Description
CD74, a Type-II transmembrane protein, is a unique member of RIP-processed protein family. It consists of an extracytoplasmic domain, a transmembrane segment and an intracytoplasmic domain. It is expressed in B-cells, monocytes, macrophages and other Class II MHC expressing cells. CD74 associates with alpha and beta chains of HLA-DR (MHC class II) and directs intracellular sorting of MHC class II molecules. It has a prominent role in antigen presentation and as an accessory signaling molecule. Cell-surface CD74 binds to MIF and its expression is required for MIF-mediated ERK1/2-phosphorylation, PGE2 production and cell proliferation. CD74 regulates B-cell differentiation and acts as a survival receptor through activation of NF-kB p65/RelA homodimer. Pathological role of CD74 has been identified in different cancers including Multiple Myeloma.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antigen sequence
SU-DHL-4 lymphoma cells were used a
s the immunogen for the CD74 antibo
dy.
Isotype
IgG
Antibody clone number
LN-2
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
CD74 protein structure - 36-3035 shown in red.