326802

antibody from BioLegend
Targeting: CD74 DHLAG
Provider product page for 326802
Immunoprecipitation
Immunohistochemistry
Flow cytometry

Antibody data

Product number
326802 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#326802, RRID:AB_893401
Product name
Purified anti-human CD74
Antibody type
Monoclonal
Antigen
SU-DHL-4 cells
Description
CD74 is a type II transmembrane glycoprotein, also known as MHC Class II associated invariant chain, invariant chain, Ii, MHC class II chaperone, or MIF receptor. CD74 exists in 4 isoforms with the molecular sizes 33, 35, 41, and 43 kD depending on genetic splicing. CD74 is primarily expressed on antigen presenting cells, including B cells, monocytes/macrophages, dendritic cells, and Langerhans cells. It is also expressed by activated T cells, activated endothelial and epithelial cells as well as the carcinomas of lung, renal, gastric and thymic origin. The primary function of CD74 is for intracellular sorting of the MHC class II molecules, regulation of loading exogenous peptides onto MHC class II. It is also involved in the modulation of B cell differentiation and positive selection of CD4+ T cells. It has been reported that CD74 binds MIF (macrophage migration inhibitory factory) and signaling through CD44 to regulate innate and adaptive immunity, and that the H. pylori infection is through urease B binding CD74 on gastric epithelial cells and inducing cell activation.
Reactivity
Human, Simian
Host
Mouse
Conjugate
Unconjugated
Isotype
IgG
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
The antibody solution should be stored undiluted at 4°C.
CD74 protein structure - 326802 shown in red.