SEMA5B

This gene encodes a member of the semaphorin protein family which regulates axon growth during development of the nervous system. The encoded protein has a characteristic Sema domain near the N-terminus, through which semaphorins bind to plexin, and five thrombospondin type 1 repeats in the C-terminal region of the protein. The protein product may be cleaved and exist as a secreted molecule (PMID: 19463192). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Description

Semaphorin 5B

Tissue specificity

Tissue enhanced (brain)

Subcell location

Cytosol

Predicted location

Intracellular, Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Kim et al 2014)

Chromosome

3 (122909082 - 123028605)

Ensembl ID

ENSG00000082684  (ver. 103.38)

Orthologs

Mouse Sema5b: ENSMUSG00000052133

UniProt

Q9P283

neXtProt

NX_Q9P283

Human splice variants
Mouse splice variants

Protein structure