ELOA2

This gene encodes the transcriptionally active subunit of the SIII (or elongin) transcription elongation factor complex, which also includes two regulatory subunits, elongins B and C. This complex acts to increase the rate of RNA chain elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites along the DNA template. Whereas a related protein with similar function, elongin A, is ubiquitously expressed, the encoded protein is specifically expressed in the testis, suggesting it may have a role in spermatogenesis. [provided by RefSeq, Jul 2008]

Description

Elongin A2

Tissue specificity

Group enriched (brain, choroid plexus, testis)

Subcell location

Nucleoplasm, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Chromosome

18 (47032572 - 47035621)

Ensembl ID

ENSG00000206181  (ver. 103.38)

Orthologs

-

UniProt

Q8IYF1

neXtProt

NX_Q8IYF1

Human splice variants

Protein structure