BS5698

antibody from Bioworld Technology, Inc
Targeting: DHRS2 HEP27, SDR25C1
Provider product page for BS5698

Antibody data

Product number
BS5698 - Provider product page
Provider
Bioworld Technology, Inc
Product name
DHRS2 polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic peptide, corresponding to the 156-201 of Human DHRS2.
Description
DHRS2 (dehydrogenase/reductase (SDR family) member 2), also known as SDR25C1 or HEP27, is a 258 amino acid protein that localizes to the nucleus and belongs to the short-chain dehydrogenase/reductase (SDR) family. Functioning as an NADPH-dependent dicarbonyl reductase, DHRS2 is thought to inhibit cell replication by either converting cortisone in cortisol, or by catalyzing the oxidation of androgen and estrogen. The gene encoding DHRS2 maps to human chromosome 14, which houses over 700 genes and comprises nearly 3.5% of the human genome. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease (AD). The SERPINA1 gene is also located on chromosome 14 and, when defective, leads to the genetic disorder Ï«1-antitrypsin deficiency, which is characterized by severe lung complications and liver dysfunction.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
DHRS2 protein structure - BS5698 shown in red.