Antibody data

Product number
BS60118 - Provider product page
Provider
Bioworld Technology, Inc
Product name
AXIN1 polyclonal antibody
Antibody type
Polyclonal
Antigen
A synthetic peptide corresponding to residues in Human AXIN1.
Description
ÉÇ-catenin is a component of both the cadherin cell adhesion system and the Wnt signaling pathway. Wnt signaling increases the amount of ÉÇ-catenin by preventing its ubiquitination and degradation, allowing its direct interaction with transcription factors of the lymphoid enhancer factor/T cell factor family, and modulation of gene expression. Axin is involved in the degradation of ÉÇ-catenin by acting as a scaffold to form a complex between ÉÇ-catenin, adenomatous polyposis coli (APC) and GSK-3ÉÇ. APC, which is phosphorylated by GSK-3ÉÇ, induces degradation of ÉÇ-catenin, thus inhibiting Wnt signal transduction. Conductin is 45% identical to Axin and appears to play a similar role to Axin in the Wnt signaling pathway.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
AXIN1 protein structure - BS60118 shown in red.