IL5RA

The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported. [provided by RefSeq, Jul 2011]

Description

Interleukin 5 receptor subunit alpha

Tissue specificity

Tissue enhanced (brain, choroid plexus, fallopian tube)

Predicted location

Intracellular, Membrane

Protein family

CD markers
FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Kim et al 2014)

Chromosome

3 (3066324 - 3126613)

Ensembl ID

ENSG00000091181  (ver. 103.38)

Orthologs

Mouse Il5ra: ENSMUSG00000005364

UniProt

Q01344

neXtProt

NX_Q01344

Human splice variants
Mouse splice variants

Protein structure