CABT-Z338M

antibody from Creative Diagnostics

Targeting: SUN2 UNC84B

Western blot (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

CABT-Z338M

Provider

Creative Diagnostics

Product name

Mouse Anti-Human SUN2 (SUN domain-containing protein 2) Monoclonal Antibody, clone 4.2F

Antibody type

Monoclonal

Description

SUN (Sad1, UNC-84) domain-containing proteins are type II membrane proteins that span the inner nuclear membrane. SUN proteins interact with lamins and other proteins in the nucleoplasm and with KASH (Klarsicht, ANC-1, and Syne homology) domain-containing proteins in the perinuclear space. Since the KASH proteins span the outer nuclear membrane and interact with components of the cytoskeleton, the SUN-KASH complex, also known as the LINC complex (LInker of the Nucleoskeleton and Cytoskeleton), provides a physical link between the nuclear interior and the cytoskeleton. The LINC complex is involved in diverse cellular functions including nuclear architecture, nuclear anchorage and migration, meiotic chromosome movement and cytoskeletal organization. Not surprisingly, aberrations in the LINC complex have been associated with number of human genetic diseases, including muscular dystrophy, cerebellar ataxia, hearing loss and infertility. In mammals the SUN protein family consists of at least 5 members. Sun1 and Sun2 share a high degree of homology and are ubiquitously expressed. Sun3-5 are more distantly related to Sun1-2 and have limited tissue expression.

Reactivity

Human, Mouse, Rat

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

4.2F

Vial size

100 _g

Concentration

Lot specific

Storage

Store at -20°C. Aliquot to avoid repeated freezing and thawing.