338502

antibody from BioLegend

Targeting: FCER2 CD23, CD23A, CLEC4J, FCE2

Immunoprecipitation

Antibody data

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Validation data

Product number: 338502 - Provider product page
Provider: BioLegend
Proper citation: BioLegend Cat#338502, RRID:AB_1279181
Product name: Purified anti-human CD23
Antibody type: Monoclonal
Antigen: Other
Description: CD23 is a 45 kD protein, also known as Leu-20, FcεRII, IgE Fc receptor, BLAST-2, B6, and low affinity IgE receptor. It is a member of the Ig family, expressed on most mature B cells, B cells in follicular mantle (but not in proliferating germinal center cells, follicular dendritic cells, monocytes, eosinophils, Langerhans cells, and a subset of T cells (10-15% of tonsillar T cells). CD23 responds to high levels of IgE by downregulating IgE secretion. In human monocytes, CD23 triggering results in release of pro-inflammatory cytokines including TNF-α, IL-1, IL-6, and GM-CSF. CD23 can be proteolytically cleaved to generate soluble CD23 fragments of various molecular weights. In chronic lymphocytic leukemia, levels of soluble CD23 in the serum can be used as a prognostic marker to identify patients at high risk for disease progression. Alternate splicing of exon 2 can also generate two cell-surface isoforms of CD23 differing by 6 amino acids in their cytoplasmic region.
Reactivity: Human
Host: Mouse
Conjugate: Unconjugated
Antibody clone number: EBVCS-5
Vial size: 100 µg
Concentration: 0.5 mg/ml
Storage: 2°C-8°C
Handling: Ambient RT

FCER2 protein structure - 338502 shown in red.