BS6944

antibody from Bioworld Technology, Inc
Targeting: COCH COCH-5B2, DFNA31, DFNA9
Provider product page for BS6944
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS6944 - Provider product page
Provider
Bioworld Technology, Inc
Product name
COCH polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human COCH.
Description
Cochlin is a secreted protein encoded by the coagulation factor C homology (COCH) gene, a cochlear gene. It constitutes 70% of the inner ear proteins and is classified into three glycosylated isoforms: p63s, p44s and p40. Cochlin contains an N-terminal LCCL domain and two von Willebrand factor A-like domains. Mutations in the COCH gene cause DFNA9, an autosomal dominant nonsyndromic auditory and vestibular dysfunction disorder, as a result of either an amino acid deletion in the LCCL domain or missense substitutions. Microfibrillar deposits accumulate in the inner ear of individuals with DFNA9 and these deposits may contain the Cochlin protein. Cochlin is a target antigen for autoimmune sensorineural hearing loss.
Reactivity
Human, Mouse
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
COCH protein structure - BS6944 shown in red.