abx015977

antibody from Abbexa

Targeting: RICTOR AVO3, KIAA1999, MGC39830, PIA

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Antibody Data

Product number

abx015977

Provider

Abbexa

Product name

RPTOR Independent Companion of MTOR Complex 2 (RICTOR) Antibody

Antibody type

Monoclonal

Description

Cell growth is a fundamental biological process whereby cells accumulate mass and increase in size.The mammalian TOR (mTOR) pathway regulates growth by coordinating energy and nutrient signals with growth factor-derived signals.mTOR is a large protein kinase with two different complexes.One complex contains mTOR, G beta L and raptor, which is a target of rapamycin.The other complex, insensitive to rapamycin, includes mTOR, G beta L, Sin1 and rictor.The mTOR-rictor complex phosphorylates Ser473 of Akt/PKB in vitro.This phosphorylation is essential for full Akt/PKB activation.Furthermore, an siRNA knockdown of rictor inhibits Ser473 phosphorylation in 3T3-L1 adipocytes.This complex has also been shown to phosphorylate the rapamycin-resistant mutants of S6K1, another effector of mTOR.

Reactivity

Human, Mouse, Simian

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µl

Storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.